A5002337843- Synthesis and Characterization of Heterocyclic Compounds
- Chemical Synthesis and Reactions
- Chemical Synthesis and Analysis
- HIV/AIDS drug development and treatment
- Synthesis of heterocyclic compounds
- Synthesis and biological activity
- Quinazolinone synthesis and applications
- Sulfur-Based Synthesis Techniques
- Click Chemistry and Applications
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Synthesis and Biological Evaluation
- Biochemical and Molecular Research
- RNA Interference and Gene Delivery
- Organometallic Compounds Synthesis and Characterization
- HIV Research and Treatment
- Immune Cell Function and Interaction
- Synthesis and Catalytic Reactions
- Carbohydrate Chemistry and Synthesis
- Liver Disease Diagnosis and Treatment
- Inorganic and Organometallic Chemistry
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- DNA and Nucleic Acid Chemistry
- CAR-T cell therapy research
- Adenosine and Purinergic Signaling
Liminal BioSciences (Canada)
2020
BioPhage Pharma (Canada)
1999-2001
CTI BioPharma (United Kingdom)
1994-1997
Supratek Pharma (Canada)
1992-1993
Armand Frappier Museum
1988-1990
Institut National de la Recherche Scientifique
1988
3M (United States)
1987
Numerous clinical conditions can lead to organ fibrosis and functional failure. There is a great need for therapies that could effectively target pathophysiological pathways involved in fibrosis. GPR40 GPR84 are G protein-coupled receptors with free fatty acid ligands associated metabolic inflammatory disorders. Although diverse physiological processes, no evidence has demonstrated the relevance of pathways. Using PBI-4050 (3-pentylbenzeneacetic sodium salt), synthetic analog medium-chain...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMultidentate Lewis acids. Complex of a macrocyclic tetradentate organomercuric perfluoroglutarateJames D. Wuest and Boulos ZacharieCite this: J. Am. Chem. Soc. 1987, 109, 15, 4714–4715Publication Date (Print):July 1, 1987Publication History Published online1 May 2002Published inissue 1 July 1987https://pubs.acs.org/doi/10.1021/ja00249a041https://doi.org/10.1021/ja00249a041research-articleACS PublicationsRequest reuse permissionsArticle...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMultidentate Lewis acids. Halide complexes of 1,2-phenylenedimercury dihalidesJames D. Wuest and Boulos ZacharieCite this: Organometallics 1985, 4, 2, 410–411Publication Date (Print):February 1, 1985Publication History Published online1 May 2002Published inissue 1 February 1985https://pubs.acs.org/doi/10.1021/om00121a043https://doi.org/10.1021/om00121a043research-articleACS PublicationsRequest reuse permissionsArticle...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMultidentate Lewis acids. Crystal structure of the 2:1 adduct 1,2-phenylenedimercury dichloride with tetraphenylphosphonium chlorideAndre L. Beauchamp, Marc J. Olivier, James D. Wuest, and Boulos. ZacharieCite this: Am. Chem. Soc. 1986, 108, 1, 73–77Publication Date (Print):January 1986Publication History Published online1 May 2002Published inissue 1 January 1986https://doi.org/10.1021/ja00261a012RIGHTS & PERMISSIONSArticle...
Imreg (Tyr1-Gly2-Gly3) is a well-known immunostimulant. However, it possesses short half-life. Stabilized analogues of were prepared by regioselective insertion in which peptide bonds at position 1,2 or 2,3 replaced thioamide linkages. This was achieved using new thioacylating agents based on thioacyl-fluoro-N-benzimidazolone. The synthesis and properties these reagents are described herein. modification enhanced significantly the half-life thioanalogues relative to blood. tested vitro T B...
A first-in-class series of low molecular weight trisubstituted triazines were synthesized and evaluated for their ability to mimic protein binding human IgG antibody. The structure−activity relationship (SAR) demonstrates that the 1,3-phenylenediamine component was essential robust activity. Twenty-two compounds, represented by lead molecule 34, displayed significant activity compared A. These compounds may prove useful treatment autoimmune disease.
ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTA Mild Procedure for the Reduction of Pyridine N-Oxides to Piperidines Using Ammonium FormateBoulos Zacharie, Nancie Moreau, and Christopher DockendorffView Author Information BioChem Pharma Inc., 275 Armand-Frappier Boulevard, Laval, Quebec, Canada H7V 4A7 [email protected]Cite this: J. Org. Chem. 2001, 66, 15, 5264–5265Publication Date (Web):June 26, 2001Publication History Received26 March 2001Published online26 June inissue 1 July...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMultidentate Lewis acids. Crystal structure of the 1:1 complex dichloro(1,2-phenylene)dimercury with dimethylformamideAndre L. Beauchamp, Marc J. Olivier, James D. Wuest, and Boulos. ZacharieCite this: Organometallics 1987, 6, 1, 153–156Publication Date (Print):January 1987Publication History Published online1 May 2002Published inissue 1 January 1987https://pubs.acs.org/doi/10.1021/om00144a028https://doi.org/10.1021/om00144a028research-articleACS...
Abstract Non-alcoholic Fatty Liver Disease (NAFLD) is the most common form of liver disease and associated with metabolic dysregulation. Although G protein-coupled receptor 84 (GPR84) has been inflammation, its role in regulation remains elusive. The aim our study was to evaluate potential PBI-4547 for treatment NAFLD validate main target receptor, GPR84. We report that a fatty acid mimetic, acting concomitantly as GPR84 antagonist GPR40/GPR120 agonist. In mouse model diet-induced obesity,...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA Simple One-Step Conversion of Carboxylic Acids to Esters Using EEDQBoulos Zacharie, Timothy P. Connolly, and Christopher L. PenneyCite this: J. Org. Chem. 1995, 60, 21, 7072–7074Publication Date (Print):October 1, 1995Publication History Published online1 May 2002Published inissue 1 October 1995https://pubs.acs.org/doi/10.1021/jo00126a080https://doi.org/10.1021/jo00126a080research-articleACS PublicationsRequest reuse permissionsArticle...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMultidentate Lewis acids. Reduction of thioketones in the presence organomercury trifluoroacetatesJames D. Wuest and Boulos ZacharieCite this: J. Am. Chem. Soc. 1985, 107, 21, 6121–6123Publication Date (Print):October 1, 1985Publication History Published online1 May 2002Published inissue 1 October 1985https://pubs.acs.org/doi/10.1021/ja00307a058https://doi.org/10.1021/ja00307a058research-articleACS PublicationsRequest reuse permissionsArticle...
N. Nguyen-Ba, W. L. Brown, Chan, Lee, Brasili, D. Lafleur and B. Zacharie, Chem. Commun., 1999, 1245 DOI: 10.1039/A901927H
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAllylstannanes. Synthesis, structure, and reactions of 2-methylene-1,3-propanediylbis[trimethylstannane] -[triphenylstannane]Sosale Chandrasekhar, Stephan Latour, James D. Wuest, Boulos ZacharieCite this: J. Org. Chem. 1983, 48, 21, 3810–3813Publication Date (Print):October 1, 1983Publication History Published online1 May 2002Published inissue 1 October...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNovel modifications of peptides: simple syntheses difunctionalized enamines, enol ethers, and thioenol ethers from carboxylic acids via acylimidazole phosphate intermediatesGilles Sauve, Nicolas Le Berre, Boulos ZacharieCite this: J. Org. Chem. 1990, 55, 10, 3002–3004Publication Date (Print):May 1, 1990Publication History Published online1 May 2002Published inissue 1...
Abstract Low‐molecular‐weight synthetic molecules 1 with the general 2‐(fluorophenylamino)‐4,6‐disubstituted 1,3,5‐triazine structure and showing anti‐inflammatory anticancer activities were explored. Structure–activity relationship studies demonstrated importance of aminopentyl chain, 3‐ or 4‐fluorophenylaniline component, presence at least one substituent, such as a tyramine moiety, attached directly to triazine ring essential for good activity. These compounds, represented by leads...
A series of 6-substituted purinyl alkoxycarbonyl amino acids were synthesized and evaluated for their ability to stimulate cytotoxic T lymphocytes (CTLs) the mixed lymphocyte reaction (MLR). few these compounds, in particular [[5-[6-(N,N-dimethylamino)purin-9-yl]pentoxy]carbonyl]d-arginine (BCH-1393, 4a), displayed an vitro stimulation CTLs comparable interleukin 2 (IL 2). BCH-1393 increased CTL response between 10-9 M 10-5 M. Further, this potent activity was reflected as a significant...
Abstract The structure-activity relationship of sixteen 3-deaza, C-4 substituted pyrimidines and imidazo[1,2-c]pyrimidine bases 1,3-oxathiolanes 1,3-dioxolanes revealed good anti-HBV activity in 2.2.15 cells transfected with human hepatitis B virus the nucleosides 21, 25 29. Two procedures for preparation analogues are reported based on nucleophilic displacement a sulfonamide or imidazole by variety nitrogen nucleophiles.