A5107843945- Angiogenesis and VEGF in Cancer
- Acute Myeloid Leukemia Research
- Hematopoietic Stem Cell Transplantation
- Chronic Lymphocytic Leukemia Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Lymphatic System and Diseases
- Bone and Dental Protein Studies
- Kruppel-like factors research
- Acute Lymphoblastic Leukemia research
- Multiple Myeloma Research and Treatments
- Cancer, Hypoxia, and Metabolism
- Lymphoma Diagnosis and Treatment
- Chronic Myeloid Leukemia Treatments
- Astrophysics and Cosmic Phenomena
- Clinical Laboratory Practices and Quality Control
- Immunotherapy and Immune Responses
- Systemic Lupus Erythematosus Research
- Immune Cell Function and Interaction
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Bone health and treatments
- Neutrino Physics Research
- Immune cells in cancer
- Cancer Cells and Metastasis
- Immunodeficiency and Autoimmune Disorders
- Atherosclerosis and Cardiovascular Diseases
Medical University of Lodz
2007-2025
Copernicus Memorial Hospital
2005-2025
The circulating endothelial cells (CEC) are proposed to be a non-invasive marker of angiogenesis. level CEC in peripheral blood (PB) acute myeloid leukemia (AML) patients has not been investigated prior this study. We evaluated the count resting (rCEC), activated (aCEC) and progenitor (CEPC) PB AML healthy subjects. In addition we correlated levels with disease status, known prognostic factors response treatment.CEC were quantified by utilizing four-color flow cytometry procedures 48 at time...
In the last decade, peripheral blood was main source of hematopoietic stem cells (HSC) for autologous and allogeneic transplantation. The exact mechanisms HSC mobilization are still not clear efficacy procedure is hardly predictable. Ligand-receptor interactions adhesion molecules, such as SDF1/CXCR4, VLA4/VCAM-1, or CD44/osteopontin, play an important role in homing niche. There some evidence that disruption ligand-receptor complex leads to egress HSCs blood. aim present study evaluation...
Recent studies have shown that angiogenesis plays an important role in the biology of hematological malignancies including essential thrombocythemia (ET). Using cytofluorimetric analysis, levels angiogenic factors, as well number circulating endothelial cells (CECs), were determined 65 patients with ET, 33 previously untreated and 32 receiving cytoreductive therapy. Correlations between markers JAK2–V617F mutational status also assessed. We found significantly higher vascular growth factor...
The aim of our study was to assess absolute counts different subpopulations circulating endothelial cells (CEC) in patients with active and inactive systemic lupus erythematosus (SLE). We have also investigated a potential correlation CEC numbers serum levels angiogenic proteins as well clinical laboratory symptoms the disease. For first time SLE, were enumerated directly, by 'single platform' method. Resting (rCEC), activated (aCEC) progenitor (pCEC) identified SLE healthy volunteers using...
An increased angiogenesis has been documented in bone marrow and lymph nodes of patients with chronic lymphocytic leukemia (CLL). There is accumulating evidence that circulating endothelial cells (CECs) play an important role angiogenesis. The aim our study was to compare the number CECs peripheral blood CLL healthy donors correlate these numbers microvessel density (MVD) known prognostic factors CLL. Proportions resting (rCECs), activated (aCECs), apoptotic (apoCECs) precursor (CPECs) were...
Objective: Circulating endothelial cells (CECs) in patients with hematological malignancies are assessed as a noninvasive marker of angiogenesis. The aim this study was to evaluate the numbers CECs and their subsets during mobilization hematopoietic stem cells. Patients methods: Thirty‐eight were enrolled (19 females 19 males) at median age 56.5 years. group consisted multiple myeloma (26), lymphoma (10), acute myeloid leukemia (2). Blood samples collected before chemotherapy (0), 1 day...
A diagnosis of typical chronic lymphocytic leukemia (CLL) requires the presence ≥5000 clonal B-lymphocytes/μL with coexistence CD19, CD20, CD5, and CD23 restriction light chain immunoglobulin, lack expression antigens CD22 CD79b. Atypical CLL (aCLL) can be distinguished from morphologically immunophenotypically. cells are defined as prolymphocytes; morphologically, these present deeply-clefted lymphocytes which larger than those in CLL, condensed chromatin without prominent nucleoli....
The bone marrow niche functions are modulated by complicated cytokines network. aim of our study was to evaluate the levels VCAM‐1, VEGF, MMP‐9 and SDF during mobilization CD34+ cells in patients with hematological malignancies. Thirty four were enrolled (19F, 15 M) at median age 57 years. group consisted multiple myeloma (26) lymphoma (8). procedures comprised chemotherapy then G‐CSF. Blood samples collected before ( N = 34) on day first apheresis 26). Cytokines evaluated ELISA assay. We...
We present the results of a prospective, non-randomized phase 2 trial in which 253 AML patients (pts) under 60 years old received DAC (Daunorubicin + AraC Cladribine) as first induction followed by CLAM (Cladribine Mitoxantrone) early second on day 16 based bone marrow (BM) blasts 14 (D14). The CR/CRi rate after single course was 83% for pts with D14 BM less than 10%. Forty-six had >10% D14, whom 35 rates 60% and death (ED) 23%. remaining 11 were not fit to receive CLAM, 28%, PR 18%, ED 18%....