A5009610404- Mitochondrial Function and Pathology
- Genetics, Aging, and Longevity in Model Organisms
- Coenzyme Q10 studies and effects
- Health and Medical Research Impacts
- Metabolism, Diabetes, and Cancer
- Spaceflight effects on biology
- GABA and Rice Research
- Alzheimer's disease research and treatments
- Aging, Health, and Disability
- Pancreatic function and diabetes
Instituto de Biomedicina y Genética Molecular de Valladolid
2023-2025
Universidad de Valladolid
2023-2025
Consejo Superior de Investigaciones Científicas
2023-2025
Harvard University
2024
We have previously shown that the compound CGP37157, a mitochondrial Na+/Ca2+ exchanger inhibitor, increases lifespan and improves muscle structure during aging in wild-type C. elegans nematodes. used here rotenone model of Parkinson's disease to test ability CGP37157 rescue alterations induced by toxicant. Rotenone, respiratory chain complex I reduced worm activity, measured as mobility, pharyngeal pumping, defecation rate. It also increased ROS production, decreased membrane potential,...
Introduction: The high prevalence of neurodegenerative diseases in our population and the lack effective treatments encourage search for new therapeutic targets these pathologies. We have recently described that submaximal inhibition Sarco-Endoplasmic Reticulum Ca 2+ ATPase (SERCA), main responsible ER calcium storage, is able to increase lifespan Caenorhabditis elegans worms by mechanisms involving mitochondrial metabolism nutrient-sensitive pathways. Methods: studied here effects SERCA a...
Mitochondria exhibit a close interplay between their structure and function. Understanding this intricate relationship requires advanced imaging techniques that can capture the dynamic nature of mitochondria impact on cellular processes. However, much work mitochondrial dynamics has been performed in single celled organisms or vitro cell culture. Here, we introduce novel genetic tools for live morphology nematode Caenorhabditis elegans , addressing pressing need studying organelle within...
Glucose sensing in pancreatic β-cells depends on oxidative phosphorylation and mitochondria-derived signals that promote insulin secretion. Using mass spectrometry-based phosphoproteomics to search for downstream effectors of glucose-dependent signal transduction INS-1E insulinoma cells, we identified the outer mitochondrial membrane protein SLC25A46. Under resting glucose concentrations, SLC25A46 was phosphorylated a pair threonine residues (T44/T45) dephosphorylated response...
Mitochondria exhibit a close interplay between their structure and function. Understanding this intricate relationship requires advanced imaging techniques that can capture the dynamic nature of mitochondria impact on cellular processes. However, much work mitochondrial dynamics has been done in single celled organisms or vitro cell culture. Here, we introduce novel genetic tools for live networks nematode
Caenorhabditis elegans (C. elegans) es un nematodo no parásito ampliamente utilizado como modelo animal de investigación científica. Se trata pluricelular con tejidos y anatomía simple, que alcanza número fijo células en su etapa adulta, 959, las cuales 302 son neuronas [1]. Es precisamente sencillez lo le confiere gran valor animal. La simplicidad este facilita la comprensión complejas vías señalización celular mamíferos, los procesos neurodegenerativos, cuyo mecanismo bioquímico animales...