A5089668902- Advanced Radiotherapy Techniques
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Radiation Therapy and Dosimetry
- Head and Neck Cancer Studies
- Prostate Cancer Diagnosis and Treatment
- Brain Metastases and Treatment
- Prostate Cancer Treatment and Research
- Glioma Diagnosis and Treatment
- Advances in Oncology and Radiotherapy
- Medical Imaging Techniques and Applications
- Meningioma and schwannoma management
- Cancer Genomics and Diagnostics
- Boron Compounds in Chemistry
- Lung Cancer Research Studies
- Sarcoma Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Hepatocellular Carcinoma Treatment and Prognosis
- Pancreatic and Hepatic Oncology Research
- Renal cell carcinoma treatment
- HER2/EGFR in Cancer Research
- MRI in cancer diagnosis
- Advanced X-ray and CT Imaging
- Cardiac tumors and thrombi
Hebrew University of Jerusalem
2023-2025
Hadassah Medical Center
2021-2025
University Medical Center
2024
Hadassah Academic College
2022-2024
Hadassah
2023
Tel Aviv Sourasky Medical Center
2023
Rush University Medical Center
2014-2020
Saint Francis Hospital
2019
Assuta Medical Center
2017
Rush University
2016
Abstract Background Adaptive radiation therapy (ART) offers a dynamic approach to address structural and spatial changes that occur during radiotherapy (RT) for locally advanced head neck cancers. The integration of daily ART with Cone-Beam CT (CBCT) imaging presents solution enhance the therapeutic ratio by addressing inter-fractional changes. Methods We evaluated initial clinical experience patients cancer using an online adaptive platform intelligence-assisted workflows on CBCT. Treatment...
Abstract Purpose To quantify needle placement accuracy of magnetic resonance image (MRI)‐guided core biopsy the prostate. Materials and Methods A total 10 biopsies were performed with 18‐gauge (G) via a percutaneous transperineal approach. Needle error was assessed by comparing coordinates preplanned targets tip measured from intraprocedural coherent gradient echo images. The source these errors subsequently investigated measuring displacement caused deflection susceptibility artifact shift...
Community-level socioeconomic status, particularly insurance is increasingly becoming important as a possible determinant in patient outcomes.To determine the association of and community-level status with outcome for patients pharyngeal squamous cell carcinoma (SCC).This study extracted data from more than 1500 Commission on Cancer-accredited facilities collected National Cancer Database. A total 35 559 diagnosed SCC pharynx 2004 through 2013 were identified. The χ2 test, Kaplan-Meier...
Introduction: Radiation therapy plays an important role in the treatment of localized breast cancer. Hypofractionated (HF) radiation has emerged as a promising alternative to conventional fractionation (CF) schedules, offering comparable efficacy with reduced duration and costs. However, concerns remain regarding its safety rate toxicity, particularly patients undergoing mastectomy reconstruction. This study aimed assess implant-related complications cancer receiving HF post-mastectomy...
Introduction Immune checkpoint inhibitors (ICI) have improved outcomes in non-small cell lung cancer (NSCLC). Nevertheless, the clinical benefit of ICI as monotherapy or combination with chemotherapy remains widely varied and existing biomarkers limited predictive value. We present an analysis ENLIGHT-DP, a novel transcriptome-based biomarker directly from histopathology slides, patients adenocarcinoma (LUAD) treated platinum-based chemotherapy. Methods retrospectively scanned...
Background: Retrospective studies suggest that local radiotherapy on the prostate improves overall survival in metastatic setting, but its benefit patients with high-burden disease is still uncertain. Methods: We conducted a retrospective study of 100 high-metastatic-burden cancer at Hadassah Ein Karem Medical Center from 2004 to 2021. Patients receiving RT alongside standard treatment were compared those alone. Prostate involved EBRT prostate/seminal vesicles with/without pelvic lymph...
741 Background: This study aims to report the initial feasibility, safety, and tumor response of delivering Diffusing Alpha-Emitter Radiation Therapy (Alpha DaRT) pancreas. innovative approach involves interstitial implantation a novel alpha-emitting radiation source via endoscopic ultrasound (EUS) for treatment pancreatic cancer. Methods: The enrolled patients treated with Alpha DaRT pancreas across two protocols (PANC ALL). primary objective was assess safety delivery target lesion EUS,...
The clinical development of new drugs with radiation appears to be limited. We hypothesised that phase I trials therapy (RT) are initiated too late into a drug's lifetime, impeding the ability complete RT-drug programmes before patent expiration.We identified novel drug-radiation combination performed between 1980 and 2012 within PubMed ClinicalTrials.gov databases. Data gathered for each drug included: date initial trial with/without RT was opened/published, published positive III trials,...
Background: Stereotactic body radiation therapy (SBRT) is often delivered in patients with oligometastatic disease (OMD). However, the specific subset of polymetastatic non-small cell lung cancer (NSCLC) on novel systemic therapies who develop induced oligopersistant (OpersisD) or oligoprogressive (OprogD), as defined by European Organisation for Research and Treatment Cancer (EORTC) OMD classification, has not been well described. This study explores outcomes treated this strategy.
Sarcoma classification is challenging and can lead to treatment delays. Previous studies used DNA aberrations machine-learning classifiers based on methylation profiles for diagnosis. We aimed classify sarcomas by analyzing signatures obtained from low-coverage whole-genome sequencing, which also identifies copy-number alterations. was extracted 23 suspected sarcoma samples sequenced an Oxford Nanopore sequencer. The methylation-based classifier, applied in the nanoDx pipeline, customized...
There is increasing awareness of the special needs for care elderly cancer patient. Newer precise conformal radiotherapy techniques allow safe delivery higher doses to target tumor while reducing dose surrounding critical organs. This has led a shortening protocols both curative and palliative indications. We review these novel published clinical studies that include patients treated with techniques. Despite fact are growing significant proportion patients, need in expected rise life...
Among radiation induced arterial complications, stenoses and occlusions are commonly reported. Radiation pseudoaneurysms (PSA) their management outcomes rarely reported.A 48 year old male underwent low anterior resection surgery for a clinically staged T2N0M0 rectal adenocarcinoma adjuvant chemoradiation the findings of lymphovascular invasion focally positive distal margin 2 years prior to current admission. The patient now presented with syncope anemia. was hypotensive after an episode...