A5076685508- Prostate Cancer Treatment and Research
- Cancer Immunotherapy and Biomarkers
- RNA Research and Splicing
- Immunotherapy and Immune Responses
- RNA modifications and cancer
- Cancer, Lipids, and Metabolism
- RNA and protein synthesis mechanisms
- Alzheimer's disease research and treatments
- Parkinson's Disease Mechanisms and Treatments
- Prostate Cancer Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Lysosomal Storage Disorders Research
- Protein Degradation and Inhibitors
- Viral Infectious Diseases and Gene Expression in Insects
- Ubiquitin and proteasome pathways
Lund University
2024-2025
University of Washington
2016-2022
Fred Hutch Cancer Center
2019-2022
Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa
2022
Mutations in the glucosidase, beta, acid (GBA1) gene cause Gaucher's disease, and are most common genetic risk factor for Parkinson's disease (PD) dementia with Lewy bodies (DLB) excluding variants of low penetrance. Because α-synuclein-containing neuronal aggregates a defining feature PD DLB, it is widely believed that mutations GBA1 act by enhancing α-synuclein toxicity. To explore this hypothesis, we deleted Drosophila homolog, dGBA1b, compared phenotypes dGBA1b mutants presence absence...
The androgen receptor (AR) regulates mRNA-specific translation through 4EBP1, which is a druggable vulnerability in AR-deficient prostate cancer.
Advanced prostate malignancies are a leading cause of cancer-related deaths in men, large part due to our incomplete understanding cellular drivers disease progression. We investigate cancer cell dynamics at single-cell resolution from onset the development androgen independence an vivo murine model. observe expansion castration-resistant intermediate luminal type that correlates with treatment resistance and poor prognosis human patients. Moreover, transformed epithelial cells associated...
A novel mechanism of sequestering tumor suppressor mRNAs reveals new therapeutic vulnerabilities in leukemic cells.
Summary Advanced prostate malignancies are a leading cause of cancer-related deaths in men, large part due to our incomplete understanding cellular drivers disease progression. We investigated cancer cell dynamics at single-cell resolution from onset the development androgen independence vivo . observe dramatic expansion castration-resistant intermediate luminal type that correlates with treatment resistance and poor prognosis human patients. Moreover, transformed epithelial cells associated...