A5049794693- TGF-β signaling in diseases
- Mechanisms of cancer metastasis
- Cancer-related gene regulation
- Kruppel-like factors research
- Cancer Cells and Metastasis
- Endoplasmic Reticulum Stress and Disease
- Renal and related cancers
- Reproductive System and Pregnancy
- FOXO transcription factor regulation
- Neurosurgical Procedures and Complications
- Intracerebral and Subarachnoid Hemorrhage Research
- Signaling Pathways in Disease
- Stroke Rehabilitation and Recovery
- Cancer, Lipids, and Metabolism
- Epigenetics and DNA Methylation
- Acute Ischemic Stroke Management
- COVID-19 and healthcare impacts
- Digestive system and related health
- Suicide and Self-Harm Studies
- Metabolomics and Mass Spectrometry Studies
- Colorectal Cancer Treatments and Studies
- Systemic Sclerosis and Related Diseases
- Multiple and Secondary Primary Cancers
- Traumatic Brain Injury and Neurovascular Disturbances
- Smoking Behavior and Cessation
Complejo Hospitalario de Jaén
2018-2024
Andalusian Health Service
2018-2023
Instituto de Investigación Biosanitaria de Granada
2021
Junta de Andalucía
2015
Abstract Purpose: On the basis of identified stress-independent cellular functions activating transcription factor 4 (ATF4), we reported enhanced ATF4 levels in MCF10A cells treated with TGFβ1. is overexpressed patients triple-negative breast cancer (TNBC), but its impact on patient survival and underlying mechanisms remain unknown. We aimed to determine effects TNBC aggressiveness, relationships between TGFβ ATF4. Defining signaling pathways may help us identify a cell signaling–tailored...
In triple-negative breast cancer (TNBC), the pleiotropic NDRG1 (N-Myc downstream regulated gene 1) promotes progression and worse survival, yet contradictory results were documented, mechanisms remain unknown.Phosphorylation localization could drive pleiotropy, nonetheless, their role in TNBC clinical outcome was not investigated.We found enhanced p-NDRG1 (Thr346) by TGFβ1 explored whether it drives pleiotropy progression.In tissue microarrays of 81 patients, we identified that staining are...
Rheumatic diseases (RD) and hereditary thrombophilias (HT) can be associated with high-risk pregnancies. This study describes obstetric outcomes after receiving medical care at a multidisciplinary consultation (MC) compares adverse neonatal (ANOs) before an MC. is retrospective observational among pregnant women RD HT treated MC of university hospital (southern Spain) from 2012 to 2018. Absolute risk reduction (ARR) number needed treat (NNT) were calculated. A total 198 pregnancies...
Various models have been proposed to predict mortality rates for hospital patients undergoing colorectal cancer surgery. However, none developed in Spain using clinical administrative databases and are based exclusively on the variables available upon admission. Our study aim is detect factors associated with in-hospital surgery and, this basis, generate a predictive score. A population cohort analysis was obtained as all admissions during period 2008-2014, according Spanish Minimum Basic...
Conocer la frecuencia de oferta consejo clínico contra el consumo alcohol, tabaco y drogas ilegales por los especialistas internos residentes (EIR) factores relacionados con dicho consejo. Estudio multicéntrico transversal mediante encuesta autoadministrada. EIR Andalucía (España), correo electrónico. Consejo declarado ilegales, escala Likert categorizada como «frecuente»/«no frecuente». Variables independientes: edad/sexo, especialidad, país origen características del drogas. Análisis...
To know the characteristics of initial care and telephone follow-up patients with suspected COVID-19 in first wave pandemic.Observational, retrospective (audit medical records).Urban Primary Care Center Andalusia (Spain).Probable cases SARS-CoV-2 (from 20/03/15 to 20/06/15).Initial assessment (place modality) (number calls duration). Sociodemographic variables (including family structure). Clinical course (symptoms, vulnerability, tests, hospital admission outcome).Three hundred one...
Nowadays, the impact of tumor-immune microenvironment (TME) in non-small-cell lung cancer (NSCLC) prognosis and treatment response remains unclear. Thus, we evaluated expression PD-L1, tumor-infiltrating lymphocytes (TILs), transforming growth factor beta (TGF-β) NSCLC to identify differences TME, detect possible new prognostic factors, assess their relationship. We retrospectively analyzed 55 samples from patients who underwent surgery had over a 5-year follow-up. PD-L1 was determined by...
Background: To assess long-term survival and outcome in patients with spontaneous intracerebral haemorrhage admitted to Intensive Care Unit(ICU).Methods: A cohort of 336 included a multicentric study from three spanish hospitals was analysed, scoring their the Glasgow Outcome Scale(GOS) for period time longer than five years. Mortality also analysed at years according MIMIC-III (Medical Information Mart Care).Findings: Median age 62(50-70) years, Coma Score(GCS) on ICU admission 7(4-11)...
<p>Non-tracked version of the supplementary information document that includes materials and methods, references figure legends</p>
<p>Supplementary Figure 3. Screening of non-canonical molecular pathways and OncoPrint analysis the eight-gene signature.</p>
<p>Supplementary Figure 1. Patient survival with high ATF4 expression in ER+ patients. ROC curve. Differential induced by TGFβ1 and ERS. SBE motifs promoter ChiP-Seq analysis.</p>
<p>Supplementary Figure 2. Target efficiency of ATF4-siRNA, effects ATF4 knockdown on tumor cell migration, and expression in mammospheres.</p>
<div>Abstract<p><b>Purpose:</b> On the basis of identified stress-independent cellular functions activating transcription factor 4 (ATF4), we reported enhanced ATF4 levels in MCF10A cells treated with TGFβ1. <i>ATF4</i> is overexpressed patients triple-negative breast cancer (TNBC), but its impact on patient survival and underlying mechanisms remain unknown. We aimed to determine effects TNBC aggressiveness, relationships between TGFβ ATF4. Defining...
<div>Abstract<p><b>Purpose:</b> On the basis of identified stress-independent cellular functions activating transcription factor 4 (ATF4), we reported enhanced ATF4 levels in MCF10A cells treated with TGFβ1. <i>ATF4</i> is overexpressed patients triple-negative breast cancer (TNBC), but its impact on patient survival and underlying mechanisms remain unknown. We aimed to determine effects TNBC aggressiveness, relationships between TGFβ ATF4. Defining...
<p>Supplementary Figure 1. Patient survival with high ATF4 expression in ER+ patients. ROC curve. Differential induced by TGFβ1 and ERS. SBE motifs promoter ChiP-Seq analysis.</p>
<p>Supplementary Figure 3. Screening of non-canonical molecular pathways and OncoPrint analysis the eight-gene signature.</p>
<p>Non-tracked version of the supplementary information document that includes materials and methods, references figure legends</p>