A5067765434- Cellular transport and secretion
- Autophagy in Disease and Therapy
- Ion Channels and Receptors
- Mosquito-borne diseases and control
- Plant Stress Responses and Tolerance
- Viral Infections and Vectors
- interferon and immune responses
- Calcium signaling and nucleotide metabolism
- Signaling Pathways in Disease
- Endoplasmic Reticulum Stress and Disease
Shanghai Jiao Tong University
2022-2025
Shanghai Ninth People's Hospital
2025
The stimulator of interferon genes (STING) plays a critical role in innate immunity. Emerging evidence suggests that STING is important for DNA or cGAMP-induced non-canonical autophagy, which independent large part canonical autophagy machineries. Here, we report that, the absence STING, energy stress-induced upregulated rather than downregulated. Depletion Drosophila fat cells enhances basal- and starvation-induced autophagic flux. During acute exercise, knockout mice show increased flux,...
Autophagy is crucial for degrading and recycling cellular components. Fusion between autophagosomes lysosomes pivotal, directing autophagic cargo to degradation. This process driven by STX17-SNAP29-VAMP8 STX7-SNAP29-YKT6 in mammalian cells. However, the interaction STX17 YKT6 its significance remain be revealed. In this study, we challenge notion that function independently autophagosome-lysosome fusion. YKT6, through SNARE domain, forms a complex with SNAP29 on autophagosomes, enhancing...
Abstract Macroautophagy is a process that cells engulf cytosolic materials by autophagosomes and deliver them to lysosomes for degradation. The biogenesis of requires ATG2 as lipid transfer protein transport lipids from existing membranes phagophores. It generally believed endoplasmic reticulum the main source supply forming autophagosomes; whether can other organelles phagophores remains elusive. In this study, we identified new ATG2A-binding protein, ANKFY1. Depletion endosome-localized...