A5086717090- Liver physiology and pathology
- Ferroptosis and cancer prognosis
- Mesenchymal stem cell research
- Drug Transport and Resistance Mechanisms
- Autophagy in Disease and Therapy
- Drug-Induced Hepatotoxicity and Protection
- Liver Disease Diagnosis and Treatment
- Tissue Engineering and Regenerative Medicine
- Genomics, phytochemicals, and oxidative stress
- Cancer, Lipids, and Metabolism
Beijing YouAn Hospital
2021-2022
Capital Medical University
2021-2022
Although massive hepatocyte cell death and oxidative stress constitute major events of acute-on-chronic liver failure (ACLF), the relationship ferroptosis with ACLF has yet to be explored. Nuclear factor erythroid 2-related 2 (Nrf2) is a key regulator ferroptosis. However, if Nrf2 modulates through remains unknown. Here, tissues patients were collected murine models using carbon tetrachloride, D-galactosamine, lipopolysaccharide as well an H2O2-induced injury model established. Upon ACLF,...
Acute-on-chronic liver failure (ACLF) is a lethal syndrome with remarkable short-term death rate. Even worse, effective internal medicine therapies are currently lacking. Increasing evidence indicates apoptosis plays critical role in the progression of failure. PINK1 has an essential function maintaining cell survival. However, and underlying mechanism ACLF incompletely understood. Herein, our team discovered that remarkably improved ACLF, featured by reduction aspartate aminotransferase...