A5008458909- Advanced biosensing and bioanalysis techniques
- RNA modifications and cancer
- RNA Interference and Gene Delivery
- MicroRNA in disease regulation
- Virus-based gene therapy research
- RNA and protein synthesis mechanisms
- Cancer Mechanisms and Therapy
- Cytokine Signaling Pathways and Interactions
- DNA and Nucleic Acid Chemistry
- Peptidase Inhibition and Analysis
- interferon and immune responses
- Epigenetics and DNA Methylation
- Monoclonal and Polyclonal Antibodies Research
- CAR-T cell therapy research
- Nanoplatforms for cancer theranostics
National Research Council
2020-2023
Institute for Experimental Endocrinology and Oncology
2020-2023
University of Campania "Luigi Vanvitelli"
2023
University of Naples Federico II
2020-2021
Abstract DNA methylation is a fundamental epigenetic modification regulating gene expression. Aberrant the most common molecular lesion in cancer cells. However, medical intervention has been limited to use of broadly acting, small molecule-based demethylating drugs with significant side-effects and toxicities. To allow for targeted demethylation, we integrated two nucleic acid-based approaches: DNMT1 interacting RNA (DiR) aptamer strategy. By combining inherent capabilities inhibiting an...
An important drawback in the management of glioblastoma (GBM) patients is frequent relapse upon surgery and therapy. A likely explanation that conventional therapies poorly affect a small population stem-like cancer cells (glioblastoma stem cells, GSCs) remain capable repopulating tumour mass. Indeed, development therapeutic strategies able to hit GSCs while reducing burden has become an challenge increase patient's survival. The signal transducer activator transcription-3 (STAT3) been...
The identification of new effective therapeutic options for non-small-cell lung cancer (NSCLC) represents a crucial challenge in oncology. Recent studies indicate that cancer-associated fibroblasts (CAFs) participate tumor progression by establishing favorable microenvironment promotes progression. Therefore, the development strategies inhibiting interplay between CAFs and cells is considered winning approach anti-cancer drugs. Among other factors, signal transducer activator transcription-3...
Gene therapy is a medical approach capable of correcting genetic and epigenetic alterations in pathological conditions, including cancer. Different strategies have been pursued for cancer gene therapy, aiming to restore the function tumor suppressor genes or inhibit oncogenes. These comprise use CRISPR/Cas9 editing technology therapeutic oligonucleotides, such as microRNAs, anti-microRNAs, small interfering RNAs, DNAzymes, modifiers. However, despite great potential, their broad clinical...
Hypoxia plays a crucial role in tumorigenesis and drug resistance, it is recognised as major factor affecting patient clinical outcome. Therefore, the detection of hypoxic areas within tumour micro-environment represents useful way to monitor growth patients' responses treatments, properly guiding choice most suitable therapy. To date, non-invasive hypoxia imaging probes have been identified, but their applicability vivo strongly limited due an inadequate resistance low oxygen concentration...
The aim of the research. Non-small cell lung cancer (NSCLC) represents about 80 % all cases and is oft en associated with drug resistance, relapses a poor prognosis. Th erefore, identifi cation eff ective therapeutic strategies crucial challenge in oncology. A key limit conventional anticancer treatments that they do not target permissive tumor microenvironment, which components are cancer‐associated fibroblasts (CAFs). It has been shown CAFs able to regulate malignant progression...