A5076935538- Antioxidant Activity and Oxidative Stress
- Free Radicals and Antioxidants
- Lipoproteins and Cardiovascular Health
- Liver Disease Diagnosis and Treatment
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cancer, Lipids, and Metabolism
- Liver Disease and Transplantation
- Vitamin C and Antioxidants Research
- Eicosanoids and Hypertension Pharmacology
- Nitric Oxide and Endothelin Effects
- Lipid metabolism and disorders
- HIV-related health complications and treatments
- Advanced Glycation End Products research
- Cholesterol and Lipid Metabolism
- Sirtuins and Resveratrol in Medicine
- Cardiovascular Function and Risk Factors
- Biochemical effects in animals
- Cardiac Ischemia and Reperfusion
- Adipose Tissue and Metabolism
- Circadian rhythm and melatonin
- Atherosclerosis and Cardiovascular Diseases
- HIV/AIDS drug development and treatment
- Natural Antidiabetic Agents Studies
- Acute Myocardial Infarction Research
- Electron Spin Resonance Studies
Pitié-Salpêtrière Hospital
2013-2025
Sorbonne Université
2016-2025
Assistance Publique – Hôpitaux de Paris
2016-2025
Université Paris Cité
2015-2025
Inserm
2015-2025
Unité de Technologies Chimiques et Biologiques pour la Santé
2016-2025
Centre National de la Recherche Scientifique
2006-2025
Délégation Paris 7
2023
Hôpital Charles-Foix
2014-2023
Demos
2023
Amyotrophic lateral sclerosis (ALS) is the most serious form of degenerative motor neuron disease in adults, characterized by upper and lower degeneration, skeletal muscle atrophy, paralysis, death. High prevalence malnutrition weight loss adversely affect quality life. Moreover, two thirds patients develop a hypermetabolism unknown cause, leading to increased resting energy expenditure. Inasmuch as lipids are major source for muscles, we determined status population with ALS investigated...
The aim of this study was to assess retrospectively the prevalence and predictive factors acute pancreatitis (AP) in a population patients referred our endocrinology department for evaluation very high triglyceride (TG) levels.One hundred twenty-nine (119 with type IV phenotypes 10 V according Fredrickson's classification) were hospital between 2000 2005.Twenty-six subjects (20.2% population) presented AP. This significantly younger at diagnosis hyperlipidemia (32 vs 40 years, P < 0.001) age...
Abstract Background Anderson's disease (AD) or chylomicron retention (CMRD) is a very rare hereditary lipid malabsorption syndrome. In order to discover novel mutations in the SAR1B gene and evaluate expression, as compared healthy subjects, of Sar1 protein paralogues intestine, we investigated three previously undescribed individuals with disease. Methods The SAR1B, SAR1A PCSK9 genes were sequenced. expression intestinal biopsies both normal patients was measured by RTqPCR....
Our objectives were to analyse carbohydrate metabolism in a series of ALS patients and examine potential association with parameters lipid clinical features. Glucose tolerance was assessed by the oral glucose test 21 non-diabetic compared age- sex-matched normal subjects. Lipids lactate/pyruvate ratio, levels pro-inflammatory cytokines (tumour necrosis factor-alpha interleukin-6) adipocytokines (leptin adiponectin) also measured patients. Mann-Whitney U-tests analysed continuous data...
Abstract: Melatonin (N-acetyl-5-hydroxytryptamine) is a pineal hormone widely known for its antioxidant properties, both in vivo and by direct capture of free radicals vitro. Although some metabolites oxidation products melatonin have been identified, the molecular mechanism which exerts properties has not totally unravelled. This study investigated reaction radio-induced reactive oxygen species, generated gamma radiolysis water aqueous solutions (from 20 to 200 μm), presence or absence...
Apolipoprotein (apo) E mutants are associated with type III hyperlipoproteinemia characterized by high cholesterol and triglycerides levels. Autosomal dominant hypercholesterolemia (ADH), due to the mutations in LDLR, APOB, or PCSK9 genes, is an isolated elevation of levels low-density lipoproteins (LDLs). We now report exceptionally large family including 14 members ADH. Through genome-wide mapping, analysis regional/functional candidate whole exome sequencing, we identified a mutation APOE...
Abstract Objective: To verify whether polyunsaturated fatty acids (PUFAs) can regulate the expression of nuclear receptor peroxisome proliferator‐activated γ (PPARγ) in human adipose tissue. Research Methods and Procedures: The effect various PUFAS on PPARγ1 ‐γ2 mRNA was investigated freshly isolated adipocytes prepared from fat samples obtained during surgery. PPARγ levels were also determined subcutaneous tissue biopsies 11 obese women, fasting state, to search for vivo associations...