A5014384916- Memory and Neural Mechanisms
- Neuroscience and Neuropharmacology Research
- Neurogenesis and neuroplasticity mechanisms
- Neural dynamics and brain function
- Stress Responses and Cortisol
- Nerve injury and regeneration
- Neuropeptides and Animal Physiology
- Neuroendocrine regulation and behavior
- Receptor Mechanisms and Signaling
- Bipolar Disorder and Treatment
- Single-cell and spatial transcriptomics
- Functional Brain Connectivity Studies
- Maritime and Coastal Archaeology
- Neurotransmitter Receptor Influence on Behavior
- Circadian rhythm and melatonin
- Genetics and Neurodevelopmental Disorders
- Immune Cell Function and Interaction
- Regulation of Appetite and Obesity
- Pacific and Southeast Asian Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neural Engineering
- Pharmacological Receptor Mechanisms and Effects
- Photoreceptor and optogenetics research
- Developmental Biology and Gene Regulation
- Epigenetics and DNA Methylation
University of Washington
2022-2025
Princeton University
2016-2024
The medial prefrontal cortex (mPFC) is important for cognitive flexibility, the ability to switch between two task-relevant dimensions. Changes in neuronal oscillations and alterations coupling across frequency ranges have been correlated with attention flexibility. Here we show that astrocytes mPFC of adult male Sprague Dawley rats, participate flexibility through astrocyte-specific Ca2+ binding protein S100β, which improves increases phase amplitude theta gamma oscillations. We further...
Because opioid withdrawal is an intensely aversive experience, persons with use disorder (OUD) often relapse to avoid it. The lateral septum (LS) a forebrain structure that important in aversion processing, and previous studies have linked the substance disorders. It unclear, however, which precise LS cell types might contribute maladaptive state of withdrawal. To address this, we used single-nucleus RNA-sequencing interrogate type specific gene expression changes induced by chronic morphine...
Autism spectrum disorder (ASD) is often associated with cognitive deficits and excessive anxiety. Neuroimaging studies have shown atypical structure neural connectivity in the hippocampus, medial prefrontal cortex (mPFC), striatum, regions function anxiety regulation. Adult hippocampal neurogenesis involved many behaviors that are disrupted ASD, including cognition, anxiety, social behaviors. Additionally, glial cells, such as astrocytes microglia, important for modulating during...
Behavior differs across individuals, ranging from typical to atypical phenotypes.
Mating and other behaviors emerge during adolescence through the coordinated actions of steroid hormone signaling throughout nervous system periphery. In this study, we investigated transcriptional dynamics medial preoptic area (MPOA), a critical region for reproductive behavior, using single-cell RNA sequencing (scRNAseq) in situ hybridization techniques male female mice development. Our findings reveal that estrogen receptor 1 (Esr1) plays pivotal role maturation GABAergic neurons within...
Mating and other behaviors emerge during adolescence through the coordinated actions of steroid hormone signaling throughout nervous system periphery. In this study, we investigated transcriptional dynamics medial preoptic area (MPOA), a critical region for reproductive behavior, using single-cell RNA sequencing (scRNAseq) in situ hybridization techniques male female mice development. Our findings reveal that estrogen receptor 1 (Esr1) plays pivotal role maturation GABAergic neurons within...
Mating and other behaviors emerge during adolescence through the coordinated actions of steroid hormone signaling throughout nervous system periphery. In this study, we investigated transcriptional dynamics medial preoptic area (MPOA), a critical region for reproductive behavior, using single-cell RNA sequencing (scRNAseq) in situ hybridization techniques male female mice development. Our findings reveal that estrogen receptor 1 (Esr1) plays pivotal role maturation GABAergic neurons within...
Cholinergic interneurons (ChINs) in the nucleus accumbens (NAc) have been implicated extinction of drug associations, as well related plasticity medium spiny neurons (MSNs). However, since most previous work relied on artificial manipulations, whether endogenous acetylcholine signaling relates to associations is unclear. Moreover, despite great interest opposing effects dopamine MSN subtypes, ChIN-mediated vary by subtype also Here, we find that high event frequency correlates with greater...
Adult-born granule cells (abGCs) integrate into the hippocampus and form connections with dentate gyrus parvalbumin-positive (PV+) interneurons, a circuit important for modulating plasticity. Many of these interneurons are surrounded by perineuronal nets (PNNs), extracellular matrix structures known to participate in We compared abGC projections PV+ negative-to-low intensity PNNs those high using retroviral 3R-Tau labeling adult mice, found that mossy fibers boutons more frequently located...
Excessive repetitive behavior is a debilitating symptom of several neuropsychiatric disorders. Parvalbumin-positive inhibitory interneurons in the dorsal striatum have been linked to behavior, and sizable portion these cells are surrounded by perineuronal nets (PNNs), specialized extracellular matrix structures. Although PNNs associated with plasticity disease, no previous studies investigated their involvement excessive behavior.We used histochemistry confocal imaging investigate...
The purine nucleoside adenosine has the critical autacoid function of directly linking cellular excitability to energy availability. mechanism is activated whenever rate triphosphate (ATP) utilization exceeds synthesis. In CNS neurons, produced by rapid intracellular hydrolysis nucleotides during neural excitation and then extruded into extracellular space. also ATP ectonucleotidases. Extracellular interacts with G-protein linked stereospecific receptors reestablish metabolic homeostasis...
Improvements in the speed and cost of expression profiling neuronal tissues offer an unprecedented opportunity to define ever finer subgroups neurons for functional studies. In spinal cord, single cell RNA sequencing studies support decades work on cord lineage studies, offering a unique probe adult function based developmental lineage. While Cre/Flp recombinase intersectional strategies remain powerful tool manipulate neurons, field lacks genetic tools restrict manipulations mouse at which...
SUMMARY Improvements in the speed and cost of expression profiling neuronal tissues offer an unprecedented opportunity to define ever finer subgroups neurons for functional studies. In spinal cord, single cell RNA sequencing studies 1,2 support decades work on cord lineage 3–5 , offering a unique probe adult function based developmental lineage. While Cre/Flp recombinase intersectional strategies remain powerful tool manipulate 6–8 field lacks genetic tools restrict manipulations mouse at...
Abstract Individual differences in behavior are associated with changes the correlation of neural activity between brain areas. Such ‘functional connectivity’ thought to reflect individual structure that alter flow regions. Here, contrast, we show functional connectivity and can be explained by how frequently an expresses distinct cortex-wide spatiotemporal patterns activity. This suggests variability sampling dynamics may underlie individuals’ unique behavioral phenotypes.
Abstract Cholinergic interneurons (ChINs) in the nucleus accumbens (NAc) have been implicated acquisition and extinction of drug associations, as well related plasticity medium spiny neurons (MSNs). However, since most previous work has relied on artificial manipulations, if how endogenous patterns cholinergic signaling relate to associations is unknown. Moreover, despite great interest opposing effects dopamine MSN subtypes, whether ChIN-mediated are similar or different across subtypes...