A5089998561- Muscle activation and electromyography studies
- Biological and pharmacological studies of plants
- Ultrasound and Hyperthermia Applications
- Effects of Vibration on Health
- Healthcare and Venom Research
- Spinal Hematomas and Complications
- Vagus Nerve Stimulation Research
- Laser Applications in Dentistry and Medicine
- Scoliosis diagnosis and treatment
- Neurogenesis and neuroplasticity mechanisms
- Nerve injury and regeneration
- Neuroendocrine regulation and behavior
- Pain Mechanisms and Treatments
- Pain Management and Treatment
- Spinal Fractures and Fixation Techniques
- Circadian rhythm and melatonin
- Trigeminal Neuralgia and Treatments
- Botulinum Toxin and Related Neurological Disorders
Kunming Medical University
2021-2023
Shenzhen Institutes of Advanced Technology
2021
Chinese Academy of Sciences
2021
Alzheimer's disease (AD) is the most common type of dementia but lacks effective treatment at present. Gastrodin (GAS) a phenolic glycoside extracted from traditional Chinese herb-Gastrodia elata-and has been reported as potential therapeutic agent for AD. However, its efficiency reduced AD patients due to limited BBB permeability. Studies have demonstrated feasibility opening blood-brain barrier (BBB) via focused ultrasound (FUS) overcome obstacles preventing medicines blood flow into brain...
Parkinson's disease (PD) is the second most common chronic neurodegenerative globally; however, it lacks effective treatment at present. Focused ultrasound (FUS) combined with microbubbles could increase efficacy of drug delivery to specific brain regions and becoming a promising technology for central nervous system diseases. In this study, we explored therapeutic potential FUS-mediated blood-brain barrier (BBB) opening left striatum deliver gastrodin (GAS) in subacute PD mouse model...
Focused ultrasound (FUS) is a potential tool for treating chronic pain by modulating the central nervous system. Herein, we aimed to determine whether transcranial FUS stimulation of anterior cingulate cortex (ACC) effectively improved in compress injury mice model at different stages neuropathic pain. The mechanical threshold was recorded nociceptive tests. We found elevated both short-term ( <math xmlns="http://www.w3.org/1998/Math/MathML" id="M1"> <mi>p</mi> <mo><</mo> <mn>0.01</mn>...
Low-intensity focused ultrasound (LIFU) has been shown to provide effective activation of the spinal cord neurocircuits. The aim this study was investigate effects LIFU in order alleviate spasticity following injury (SCI) by activating neurocircuits and increasing expression neuronal K-Cl cotransporter KCC2. Adult male Sprague Dawley (SD) rats (220-300 g) were randomly divided into a sham control group, LIFU- LIFU+ group. mechanical threshold hold (g) used evaluate behavioral characteristics...
Although neurocircuits can be activated by focused ultrasound stimulation, it is unclear whether this also true for spinal cord neurocircuits. In study, we used low-intensity (LIFU) to stimulate lumbar 4-lumbar 5 (L4-L5) segments of the normal Sprague Dawley rats with a clapper. The activation enhanced soleus muscle contraction as measured electromyography (EMG). Neuronal and injury were assessed EMG, western blotting (WB), immunofluorescence, hematoxylin eosin (H&E) staining, Nissl...
<title>Abstract</title> Background The International Scientific Society on Scoliosis Orthopedic and Rehabilitation Treatment (SOSORT) proposes that the effect of brace treatment combined with physiotherapeutic scoliosis-specific exercises is significantly better than either alone. Wearing full-time rigid braces 23 h a day can effectively control progression scoliosis. However, long-term wearing cause psychological disorders, dyskinesia, lung function other issues. Nevertheless, exercise...