A5103201441- Cardiac electrophysiology and arrhythmias
- Mitochondrial Function and Pathology
- Ion channel regulation and function
- ECG Monitoring and Analysis
- Cardiovascular Function and Risk Factors
- Cardiac pacing and defibrillation studies
- Cardiac Arrhythmias and Treatments
- Adipose Tissue and Metabolism
- Microbial metabolism and enzyme function
- Takotsubo Cardiomyopathy and Associated Phenomena
- Cardiovascular Effects of Exercise
- Cardiac Imaging and Diagnostics
- Heart Rate Variability and Autonomic Control
- Spaceflight effects on biology
- Vagus Nerve Stimulation Research
- Atherosclerosis and Cardiovascular Diseases
- Birth, Development, and Health
- Ubiquitin and proteasome pathways
- Polyamine Metabolism and Applications
- Adipokines, Inflammation, and Metabolic Diseases
- Circular RNAs in diseases
- Redox biology and oxidative stress
- Advanced Glycation End Products research
- Cancer-related Molecular Pathways
- Cancer-related molecular mechanisms research
Vanderbilt University Medical Center
2022-2024
Rabindranath Tagore International Institute of Cardiac Sciences
2022-2023
San Diego Cardiac Center
2023
Richard L. Roudebush VA Medical Center
2023
University of Cincinnati Medical Center
2023
Vanderbilt University
2014-2021
Johns Hopkins University
2014-2019
Johns Hopkins Medicine
2014-2019
University of Swat
2017-2019
The Ohio State University
2012-2015
Despite increasing prevalence and incidence of heart failure (HF), therapeutic options remain limited. In early stages HF, sudden cardiac death (SCD) from ventricular arrhythmias claims many lives. Reactive oxygen species (ROS) have been implicated in both contractile dysfunction. However, little is known about how ROS specific subcellular compartments contribute to HF or SCD pathophysiology. The role chronic proteome remodeling has not explored.We will test the hypothesis that elevated...
Oxidative stress arises from an imbalance in the production and scavenging rates of reactive oxygen species (ROS) is a key factor pathophysiology cardiovascular disease aging. The presence parallel pathways multiple intracellular compartments, each having its own ROS sources antioxidant enzymes, complicates determination most important regulatory nodes redox network. Here we quantified dynamics within specific compartments cytosol mitochondria determined which enzymes exert control over...
Abnormalities in cardiac energy metabolism occur heart failure (HF) and contribute to contractile dysfunction, but their role, if any, HF-related pathologic remodeling is much less established. CK (creatine kinase), the primary muscle reserve reaction which rapidly provides ATP at myofibrils regenerates mitochondrial ADP, down-regulated experimental human HF. We tested hypotheses that HF related impaired rescuing attenuates maladaptive hypertrophy
Hearts from type 2 diabetic (T2DM) subjects are chronically subjected to hyperglycemia and hyperlipidemia, both thought contribute oxidizing conditions contractile dysfunction. How redox alterations contractility interrelate, ultimately diminishing T2DM heart function, remains poorly understood. Herein we tested whether the fatty acid palmitate (Palm), in addition its energetic contribution, rescues function by improving [glutathione (GSH), NAD(P)H, less oxidative stress] rat trabeculae high...
Epicardial ablation is becoming an important part of management in patients with ventricular tachycardia (VT). Posterior epicardial access via the Sosa or needle-in-needle (NIN) approach for VT considered to be method choice most electrophysiologists. Anterior as alternative technique has recently been proposed, but there are limited data about its safety, efficacy, and rate immediate complications. In this study, we report our experience anterior between 2009 2016.Between June 2016, 100...
The need for a readily available, inexpensive, non-invasive method improved risk stratification of heart failure (HF) patients is paramount. Prior studies have proposed that distinct fluctuation patterns underlying the variability physiological signals unique prognostic value. We tested this hypothesis in an extensively phenotyped cohort HF using EntropyXQT, novel non-linear measure cardiac repolarization dynamics.In prospective, multicentre, observational study 852 sinus rhythm undergoing...
ABSTRACT The present studies examined whether the pituitary hormones, particularly prolactin, have any role in regulation of rat placental lactogen (rPL) secretion. Total rPL was measured using a lymphoma cell bioassay. Hypophysectomy on day 13 pregnancy increased total serum levels above those intact control rats and delayed for 3 days decline usually seen by 14. To test effect early hypophysectomy secretion, implantation model used. carried out 3, progesterone (2 mg) given daily until 8...
Sudden cardiac arrest (SCA) and heart failure (HF) are leading causes of death. The underlying mechanisms incompletely understood, limiting the design new therapies. Whereas most autonomic modulation therapies have not shown clear benefit in HF patients, growing evidence indicates sympathetic denervation (CSD) exerts cardioprotective effects. molecular cellular remain unexplored.Based on hypothesis that mitochondrial reactive oxygen species (mROS) drive pathogenesis SCA, we investigated...
Sudden cardiac death (SCD) from ventricular tachycardia/fibrillation (VT/VF) is a leading cause of death, but current therapies are limited. Despite extensive research on drugs targeting sarcolemmal ion channels, none have proven sufficiently effective for preventing SCD. Sarcoplasmic ryanodine receptor 2 (RyR2) Ca2+ release the downstream effectors underexplored in this context. Recent evidence implicates reactive oxygen species (ROS)-mediated oxidation and hyperactivity RyR2s...
Background: Sudden cardiac arrest (SCA) is a leading cause of death in the USA. Defibrillators prevent SCA by delivering shocks for sustained ventricular tachyarrhythmias (VT). However, current clinical methods predicting are limited. We have shown that distinct nonlinear fluctuation patterns “hidden” within normal-appearing ECG waveforms unique prognostic value. Hypothesis: Autonomous personalized dynamic analysis predicts 1-hour incidence SCA. Methods: In an established pressure-overload...
Background: The sympathetic nervous system (SNS) is a critical regulator of cardiovascular function. Whereas acute SNS activation elicits positive inotropy and confers survival advantage, persistent hyperactivity maladaptive can lead to arrhythmias, cardiac arrest heart failure. Hypothesis: Automated optogenetic modulation the stress response in vivo enhances neurocardiac function while avoiding hyperactivity-mediated pathological effects. Methods: In normal guinea pigs, we virally...
Abstract Funding Acknowledgements Type of funding sources: None. Background Differential expression microRNAs is critical in the genesis and progression atherosclerosis. MiR145 has atheroprotective role through improved homeostasis smooth muscle cells (SMC). MiR155 pro-atherogenic due to its suppression Bcl6, which antagonises NF-κB modulates macrophages. Purpose Our purpose was determine if differential miR 155 & 145 (expressed as 155:145 ratio) across various age groups risk factor...
Intro: Sudden cardiac death (SCD) from ventricular arrhythmias (VT/VF) claims more lives each year than all other disease-related causes of combined. The underlying links between HF and SCD remain unclear. Reactive oxygen species (ROS) are central to pathophysiology, but their effects depend on where how ROS generated. Employing innovative approaches, we hypothesized that mitochondrial (mROS) is a principal source oxidative stress in vivo reduction mROS mitigates SCD. Methods: In unique...
Introduction: Early diagnosis of atrial fibrillation (AF) leading to early therapy can improve clinical outcomes (e.g., stroke). Current approaches for AF risk stratification are limited. Dynamic ECG analysis during sleep is an alternate, underexplored approach stratification. Hypothesis: predicts incidence in community adults, and adds major independent prognostic value conventional factors scores. Methods: In the multi-center prospective Sleep Heart Health Study, we studied consecutive,...
Abstract Funding Acknowledgements Type of funding sources: None. Background Atherosclerosis is inherently an inflammatory process, with a complex interplay markers. It established that these markers play important role in patients Coronary Artery Disease(CAD) traditional cardiovascular risk factors. However, the inflammation atherosclerotic process CAD without factors still not clearly known. Purpose Our purpose was to determine whether factors, TLR4(Toll like receptor 4) expression as...
Sudden cardiac death (SCD) from ventricular tachycardia/fibrillation (VT/VF) are a leading cause of death, but current therapies limited. Despite extensive research on drugs targeting sarcolemmal ion channels, none have proven sufficiently effective for preventing SCD. Sarcoplasmic ryanodine receptor 2 (RyR2) Ca 2+ release the downstream effectors underexplored in this context. Recent evidence implicates reactive oxygen species (ROS)- mediated oxidation and hyperactivity RyR2s...
Abstract Introduction Sudden cardiac death (SCD) from ventricular tachycardia/fibrillation (VT/VF) are a leading cause of death, but current therapies limited. Despite extensive research on drugs targeting sarcolemmal ion channels, none have proven sufficiently effective for preventing SCD. Sarcoplasmic ryanodine receptor 2 (RyR2) Ca2+ release the downstream effectors underexplored in this context. Recent evidence implicates reactive oxygen species (ROS)-mediated oxidation and hyperactivity...
Sudden cardiac death (SCD) from ventricular tachycardia/fibrillation (VT/VF) are a leading cause of death, but current therapies limited. Despite extensive research on drugs targeting sarcolemmal ion channels, none have proven sufficiently effective for preventing SCD. Sarcoplasmic ryanodine receptor 2 (RyR2) Ca 2+ release the downstream effectors underexplored in this context. Recent evidence implicates reactive oxygen species (ROS)- mediated oxidation and hyperactivity RyR2s...