A5055359195- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- CAR-T cell therapy research
- Liver Disease Diagnosis and Treatment
- Diet, Metabolism, and Disease
- Diet and metabolism studies
- Immunotherapy and Immune Responses
- Hematopoietic Stem Cell Transplantation
- Diabetes and associated disorders
- Adipokines, Inflammation, and Metabolic Diseases
- Complement system in diseases
- Immune cells in cancer
- Pancreatic function and diabetes
University of Rijeka
2013-2024
Metabolic dysfunction-associated steatotic liver disease (MASLD) is an increasingly common complication of obesity, affecting over a quarter the global adult population. A key event in pathophysiology MASLD development metabolic-associated steatohepatitis (MASH), which greatly increases chances developing cirrhosis and hepatocellular carcinoma. The underlying cause MASH multifactorial, but accumulating evidence indicates that inflammatory process hepatic microenvironment typically follows...
Metabolic-associated fatty liver disease (MAFLD) is a spectrum of clinical manifestations ranging from benign steatosis to cirrhosis. A key event in the pathophysiology MAFLD development nonalcoholic steatohepatitis (NASH), which can potentially lead fibrosis and hepatocellular carcinoma, but triggers MAFLD-associated inflammation are not well understood. We have observed that lipid accumulation hepatocytes induces expression ligands specific activating immune receptor NKG2D. Tissue-resident...
Memory formation of activated CD8 T cells is the result a specific combination signals that promote long-term survival and inhibit differentiation into effector cells. Much known about initial cues drive memory formation, but it poorly understood which are essential during intermediate stages before terminal differentiation. NKG2D an activating coreceptor on Ag-experienced promotes cell functions. Its role in currently unknown. In this study, we show controls by promoting precursor We...
Natural killer group 2 member D (NKG2D) is an activating receptor that expressed on most cytotoxic cells of the immune system, including NK cells, γδ, and CD8+ T cells. It still a matter debate whether how NKG2D mediates priming in vivo, due to lack studies where eliminated exclusively these Here, we studied impact effector T-cell formation. deficiency restricted murine did not impair antigen-specific expansion following mouse CMV lymphocytic choriomeningitis virus infection, but reduced...
Abstract NKG2D is a potent activating receptor that expressed on cytotoxic immune cells such as CD8 T and NK cells, where it promotes cytotoxicity after binding stress ligands infected or transformed cells. On cell precursors modulates proliferation maturation. Previously, we observed deficiency affects peripheral B numbers. In this study, show regulates B1a development function. We find mice deficient for have strong reduction of As result, NKG2D-deficient produce significantly less...
Natural killer (NK) cells play an important role in the early defense against tumors and virally infected cells. Their function is thought to be controlled by balance between activating inhibitory receptors, which often compete for same ligands. Several receptors expressed on virtually all NK lack partner, most notably CD16, NCR1 NKG2D. We therefore hypothesized that a signal through at least one of these always required full cell activation. generated animals lacking three (TKO) analyzed...
Abstract NKp46/NCR1 is an activating NK‐cell receptor implicated in the control of various viral and bacterial infections. Recent findings also suggest that it plays a role shaping adaptive immune response to pathogens. Using NCR1‐deficient (NCR1 gfp/gfp ) mice, we provide evidence for NCR1 antibody mouse cytomegalovirus infection (MCMV). The absence resulted impaired maturation, function migration regional lymph nodes. In addition, CD4 + T‐cell activation follicular helper (Tfh) generation...