A5073101440- Telomeres, Telomerase, and Senescence
- Cancer, Hypoxia, and Metabolism
- Cancer-related molecular mechanisms research
- Diabetes Management and Research
- RNA modifications and cancer
- Diabetes Treatment and Management
- RNA regulation and disease
- Lipid metabolism and biosynthesis
- Circular RNAs in diseases
- Epigenetics and DNA Methylation
- RNA Research and Splicing
- Immune cells in cancer
- Viral Infectious Diseases and Gene Expression in Insects
- Pancreatic function and diabetes
- Cancer Genomics and Diagnostics
- PI3K/AKT/mTOR signaling in cancer
University of Science and Technology of China
2019-2023
China Pharmaceutical University
2016
State Key Laboratory of Natural Medicine
2016
Sestrins are a small gene family of pleiotropic factors whose actions promote cell adaptation to range stress conditions. In this report we disclose the selective role Sestrin2 (SESN2) in dampening aerobic glycolysis adapt limiting glucose Removal from hepatocellular carcinoma (HCC) cells inhibits associated with downregulation rate-limiting glycolytic enzyme hexokinase 2 (HK2). Moreover, accompanying upregulation SESN2 through an NRF2/ATF4-dependent mechanism plays direct HK2 regulation by...
The free fatty acid receptor 1 (FFA1) plays a key role in amplifying glucose-stimulated insulin secretion pancreatic β-cells.
Abstract Glutamine addiction represents a metabolic vulnerability of cancer cells; however, effective therapeutic targeting the pathways involved remains to be realized. Here, we disclose critical role interferon-related developmental regulator 1 (IFRD1) in adaptive survival hepatocellular carcinoma (HCC) cells during glutamine starvation. IFRD1 is induced under starvation inhibit autophagy by promoting proteasomal degradation key ATG14 TRIM21-dependent manner. Conversely, glutamine-deprived...
Abstract The long non-coding RNA GUARDIN functions to protect genome stability. Inhibiting expression can alter cell fate decisions towards senescence or apoptosis, but the underlying molecular signals are unknown. Here we show that is an essential component of a transcriptional repressor complex involving LRP130 and PGC1α which suppresses FOXO4 expression. acts as scaffold stabilize LRP130/PGC1α heterodimers their occupancy at promotor. Destabilizing this by silencing GUARDIN, leads...