A5000218010- Parkinson's Disease Mechanisms and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- HIV Research and Treatment
- Immune Cell Function and Interaction
- HIV/AIDS drug development and treatment
- Alzheimer's disease research and treatments
- interferon and immune responses
- Immune Response and Inflammation
- Nerve injury and regeneration
- RNA regulation and disease
- Cancer-related gene regulation
- Hemophilia Treatment and Research
- Viral Infections and Vectors
- Mosquito-borne diseases and control
- Immunodeficiency and Autoimmune Disorders
- HIV/AIDS Research and Interventions
- Immunotherapy and Immune Responses
- Atomic and Molecular Physics
- RNA Research and Splicing
- Sleep and Wakefulness Research
- Cystic Fibrosis Research Advances
- Hepatitis C virus research
- Viral Infections and Immunology Research
- Advanced Chemical Physics Studies
- Atmospheric Ozone and Climate
Aarhus University
2002-2022
Aarhus University Hospital
2014-2019
Pharmacologically-induced activation of replication competent proviruses from latency in the presence antiretroviral treatment (ART) has been proposed as a step towards curing HIV-1 infection. However, until now, approaches to reverse humans have yielded mixed results. Here, we report proof-of-concept phase Ib/IIa trial where 6 aviremic infected adults received intravenous 5 mg/m2 romidepsin (Celgene) once weekly for 3 weeks while maintaining ART. Lymphocyte histone H3 acetylation, cellular...
ABSTRACT Toll-like receptor (TLR) agonists are potent enhancers of innate antiviral immunity and may also reverse HIV-1 latency. Therefore, TLR have a potential role in the context “shock-and-kill” approach to eradicate HIV-1. Our extensive preclinical evaluation suggests that novel TLR9 agonist, MGN1703, indeed perform both functions an eradication trial. Peripheral blood mononuclear cells (PBMCs) from aviremic HIV-1-infected donors on antiretroviral therapy (ART) were incubated with...
Abstract Background PD is a multisystem disease where both central and peripheral nervous systems are affected. This systemic involvement also includes the immune response in PD, which implicates not only microglia brain, but cells, such as monocytes; however, this aspect has been understudied. Objectives The purpose of study was to investigate PD‐related changes their responsiveness stimulation, ability release immunomodulatory molecules that might have consequences for progression. Methods...
Alpha-synuclein pathology is associated with immune activation and neurodegeneration in Parkinson's disease. The involves not only microglia but also peripheral cells, such as mononuclear phagocytes found blood infiltrated the brain. Understanding involvement essential for developing immunomodulatory treatment. Therefore, we aimed to study circulating early- late-stage disease, defined by disease duration of less or more than five years, respectively, analyze their association clinical...
Significance This study shows that the myeloid immune response in isolated rapid-eye-movement sleep behavior disorder (iRBD) patients involves both brain and periphery, these responses are related, supporting a cross-talk between peripheral system. Furthermore, events were correlated with dopaminergic neuronal changes, strongly role for system process associated iRBD putatively Parkinson’s disease. These findings support monocytes as biomarkers potential targets. Future studies should...
Keratinocytes are involved in protecting the body from infections and environmental challenges, but also inflammatory conditions like psoriasis. DNA has emerged as a potent stimulator of innate immune responses, there is largely no information how keratinocytes respond to cytosolic DNA. In this study, we report that human tolerant cytoplasmic However, if treated with cytokines, gained capacity through mechanism antagonized by antimicrobial peptide LL37, proposed be activation regulation skin...
Parkinson's disease (PD) is a neurodegenerative disorder with significant immune component, as demonstrated by changes in biomarkers patients' biofluids. However, which specific cells are responsible for those unclear because most can be produced various cell types.The aim of this study was to explore monocyte involvement PD.We investigated the monocyte-specific biomarker sCD163, soluble form receptor CD163, cerebrospinal fluid (CSF) and serum two experiments, compared it other clinical...
The innate immune system has been recognized to play a role in the pathogenesis of HIV infection, both by stimulating protective activities and through contribution chronic activation, development immunodeficiency progression AIDS. A for DNA sensors recognition suggested recently, aim present study was describe influence infection on expression function intracellular sensing. Here we demonstrate impaired interferon-stimulated genes responses peripheral blood monuclear cells from HIV-positive...
Deficiency in coagulation factor VIII encoded by F8 results the X-linked recessive bleeding disorder haemophilia A (HEMA). Here we describe identification of a novel variant gene, F8, an adult male patient with severe A. The was diagnosed early childhood and subsequently co-infected Hepatitis C HIV acquired during blood transfusion for 1980ies. identified deletion, c.5411_5413delTCT, p.F1804del lies within conserved part molecule, is predicted bioinformatic software to be deleterious loss...
Abstract Among HIV-infected individuals, long-term nonprogressor (LTNP) patients experience slow CD4 T cell decline and almost undetectable viral load for several years after primary acquisition of HIV. Type I IFN has been suggested to play a pathogenic role in HIV pathogenesis, therefore diminished responses may underlie the LTNP phenotype. In this study, we examined presence possible immunological multiple homozygous single-nucleotide polymorphisms stimulator genes (STING) encoding gene...
Common CCR5-∆32 and HLA alleles only explain a minority of the HIV long-term non-progressor (LTNP) elite controller (EC) phenotypes. To identify rare genetic variants contributing to slow disease progression phenotypes, we performed whole exome sequencing (WES) on seven LTNPs four ECs. CCR5 allele status, total DNA reservoir size, as well variant-related functional differences between ECs, LTNPs, eleven age- gender-matched HIV-infected non-controllers antiretroviral therapy (NCARTs) were...
Poliovirus (PV) is one of the most studied viruses. Despite efforts to understand PV infection within host, fundamental questions remain unanswered. These include mechanisms determining progression viremia, pathogenesis neuronal and paralysis in only a minority patients. Because rare disease phenotype paralytic poliomyelitis (PPM), we hypothesize that genetic etiology may contribute course outcome.We used whole-exome sequencing (WES) investigate profile 18 patients with PPM. Functional...
ABSTRACT Parkinson’s disease is a neurodegenerative disorder with significant immune component. Numerous studies have reported alterations on biomarkers in CSF and serum that associate symptoms PD patients. However, it unclear, which specific cells are responsible for the changes those biomarkers; since most of these cytokines or chemokines, can be produced by variety cells, even neurons glia brain. Here, we investigate monocyte/macrophage-specific biomarker: sCD163, soluble form receptor...
1. Abstract Alpha-synuclein pathology is associated with immune activation and neurodegeneration in Parkinson’s disease. The involves not only microglia but also peripheral cells, such as mononuclear phagocytes found blood infiltrated the brain. Understanding involvement essential for developing immunomodulatory treatment. Therefore, we aimed to study circulating early- late-stage disease, defined by disease duration of less or more than five years, respectively, analyze their association...