A5090652627- Nanoparticle-Based Drug Delivery
- Advanced Polymer Synthesis and Characterization
- Polymer composites and self-healing
- Block Copolymer Self-Assembly
- Polymer Surface Interaction Studies
- Dendrimers and Hyperbranched Polymers
- Surfactants and Colloidal Systems
- Gold and Silver Nanoparticles Synthesis and Applications
- Luminescence and Fluorescent Materials
- Advanced Sensor and Energy Harvesting Materials
- Nanoplatforms for cancer theranostics
- Conducting polymers and applications
- Polymer Nanocomposites and Properties
- Polydiacetylene-based materials and applications
- Lignin and Wood Chemistry
- RNA Interference and Gene Delivery
- Molecular Sensors and Ion Detection
- Photonic Crystals and Applications
- Electrospun Nanofibers in Biomedical Applications
- Organic Electronics and Photovoltaics
- Mesoporous Materials and Catalysis
- Hydrogels: synthesis, properties, applications
- Photochromic and Fluorescence Chemistry
- Supramolecular Chemistry and Complexes
- Epoxy Resin Curing Processes
Guangdong University of Technology
2016-2025
Hanshan Normal University
2022-2025
Ji Hua Laboratory
2022-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2021-2025
Wenzhou Central Hospital
2025
Fuzhou University
2025
Zhejiang University of Science and Technology
2025
Wenzhou Medical University
2013-2024
Shanghai Third People's Hospital
2024
Shanghai University
2024
ConspectusHyaluronic acid (HA), which contains multiple carboxyl, hydroxyl, and acetylamino groups is an agent that targets tumors, has drawn great attention in supramolecular diagnosis treatment research. It can not only assemble directly with macrocyclic host–guest complexes through hydrogen bonding electrostatic interactions but also be modified compounds or functional guest molecules by amidation reaction used for further assembly. Macrocycles play a main role the construction of drug...
Nanoparticles target inflammatory neutrophils to deliver doxorubicin for neutrophil apoptosis in resolution of inflammation.
Dysregulated vascular inflammation is the underlying cause of acute lung inflammation/injury (ALI). Bacterial infections and trauma ALI that may rapidly lead to respiratory distress syndrome (ARDS). There are no pharmacological therapies available patients with ALI/ARDS, partially as drugs cannot specifically target lungs. Herein, we developed a stimuli-responsive nanoparticle (NP) inflammatory lungs for therapies. The NP composed sharp acid-sensitive segment poly(β-amino esters) core drug...
Chemotherapy is the main treatment for cancer therapy. However, its anti-tumor efficiency always impaired by poor bioavailability and low tumor accumulation of chemotherapeutic drugs. The variation between microenvironment normal tissue has been recognized as an effective tool to improve drug efficiency. Herein, we developed injectable, pH-responsive, in situ self-assembled drug-peptide hydrogel (MTX-KKFKFEFEF(DA)) highly efficient local chemotherapy with few side effects. small molecule...
Developing a shape memory polyurethane with high mechanical properties, excellent self-healing has become huge challenge for the development of smart materials. Herein, we report design and fabrication network terminated coumarin units (HEOMC-PU) to address this conundrum. The synthesized HEOMC-PU exhibits exceptional performance breaking elongation 746% toughness 55.5 MJ·m–3. By utilizing dynamically reversible behavior repair damaged network, efficient (99.2%) is obtained. In addition,...
Biomass polysaccharides are converted over novel high-entropy sulfides (CdZnCuCoFe)S x under mild reaction conditions via solar energy catalysis. A large amount of carbon monoxide (CO) was produced at 1.73 mmol g −1 h with a high selectivity 99.1% among the gas products.
A photo-responsive full-color lanthanide supramolecular switch was constructed from a synthetic 2,6-pyridine dicarboxylic acid (DPA)-modified pillar[5]arene (H) complexing with ion (Ln3+ = Tb3+ and Eu3+) dicationic diarylethene derivative (G1) through noncovalent assembly. Benefiting the strong complexation between DPA Ln3+ 3 : 1 stoichiometric ratio, complex H/Ln3+ presented an emerging emission in aqueous organic phase. Subsequently, network polymer formed by further encapsulating G1via...
Smart materials with outstanding self-healing and reprocessable capabilities are highly desirable for next-generation coatings that can repair damaged in a timely autonomous manner. However, their prevalent use practical applications is currently hindered by various limitations, such as low mechanical strength, long healing time, expensive raw materials. Herein, we prepared epoxy resin coating (EP-SS-DAAX) excellent properties incorporating dynamic disulfide bonds flexible chains into the...
Abstract Physical unclonable function (PUF) is attractive in modern encryption technologies. Addressing the disadvantage of slow data storage/authentication optical PUF paramount for practical applications but remains an on‐going challenge. Here, a highly efficient strategy based on random structural color domains (SCDs) cellulose nanocrystal (CNC) proposed first time, combing with hyperspectral imaging system (HIS) ultrafast storage and authentication. By controlling growth fusion behavior...
A random hydrophobic/pH-sensitive copolymer brush poly(polylactide methacrylate-co-methacrylic acid)-b-poly(poly(ethylene glycol) methyl ether methacrylate) [P(PLAMA-co-MAA)-b-PPEGMA] and its self-assembled micelles were developed for oral administration of hydrophobic drugs. The polymer was synthesized by the combination activators regenerated electron transfer atom radical polymerization (ARGET ATRP) ring opening (ROP). CMC P(PLAMA-co-MAA)-b-PPEGMA in aqueous solution extremely low (about...
Well-defined A3(BC)3 type amphiphilic miktoarm star polymers poly(ε-caprolactone)3-[poly(2-(diethylamino)ethyl methacrylate)-b-poly(poly(ethylene glycol) methyl ether methacrylate)]3 [(PCL)3-(PDEAEMA-b-PPEGMA)3] and their pH-sensitive self-assembled polymeric micelles were developed as anticancer vehicles for improved cancer therapy. These synthesized by a combination of ring opening polymerization (ROP) continuous activators regenerated electron transfer atom radical (ARGET ATRP)...
A strategy for improving the capture of CO2 was developed through entropic effect by tuning geometric construction anion-functionalized ionic liquids. Several kinds liquids with amino group at para or ortho position were designed and applied CO2, which indicates that former exhibited both higher capacity lower enthalpy, resulting in efficient energy-saving capture. Viscosity measurements, spectroscopic investigations, quantum chemical calculations showed such a unique behavior originated...
Dissipative particle dynamics (DPD) simulation was applied to investigate the microstructures of micelles self-assembled from pH-sensitive four-arm star triblock poly(ε-caprolactone)-b-poly(2-(diethylamino)ethyl methacrylate)-b-poly(poly(ethylene glycol) methyl ether methacrylate) (4AS-PCL-b-PDEAEMA-b-PPEGMA). In optimized system, have a core-mesosphere-shell three-layer structure. The drug-loading process and its distribution at different formulations in were studied. results show that DOX...
How to control the release of drugs from pH-sensitive polymeric micelles is an issue common concern, which important effectiveness micelles. The components and properties polymers can notably influence drug distributions inside a key factor that affects In this work, dissipative particle dynamics simulation method first used study structural transformation during protonation process with different distributions. And then effects polymer structures, including lengths hydrophilic blocks,...
In this work, Au nanoparticle (AuNP) arrays on shape memory polyurethane (SMPU) substrates serve as flexible materials for tunable localized surface plasmon resonance (LSPR). AuNP prepared by diblock copolymer self-assembly are transferred from rigid silicon wafers onto SMPU with ultrasonic treatment rather than peeling off directly. The resultant array films have excellent mechanical properties and stable thermodynamic properties. LSPR arising is increased negative bending substrates,...