A5100340687- Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Glaucoma and retinal disorders
- Cancer-related molecular mechanisms research
- Galectins and Cancer Biology
- Advanced Breast Cancer Therapies
- CAR-T cell therapy research
- Ferroptosis and cancer prognosis
- 14-3-3 protein interactions
- Cancer-related gene regulation
- Cancer Mechanisms and Therapy
- Telomeres, Telomerase, and Senescence
- Vitamin D Research Studies
- Chemokine receptors and signaling
- Acute Myeloid Leukemia Research
- Circular RNAs in diseases
- Proteoglycans and glycosaminoglycans research
- Cancer-related Molecular Pathways
- Glycosylation and Glycoproteins Research
- Peptidase Inhibition and Analysis
- Ubiquitin and proteasome pathways
- Immune Cell Function and Interaction
- Drug Transport and Resistance Mechanisms
- Vitamin C and Antioxidants Research
- Cancer, Lipids, and Metabolism
Second Hospital of Anhui Medical University
2020-2024
Anhui Medical University
2020-2024
Tianjin Medical University
2020
Tianjin Medical University Cancer Institute and Hospital
2020
Jining First People's Hospital
2019
In this study, we evaluated the function and regulation of long non-coding RNA (lncRNA) FAM83H-AS1 in triple-negative breast cancer (TNBC). Our data show that levels are increased human TNBC cells tissues. Proliferation, migration, invasion decreased by suppression, but overexpression. Bioinformatics analysis revealed miR-136-5p is a potential target FAM83H-AS1. MiR-136-5p expression tissues, its overexpression suppresses cell proliferation, invasion. suppression reverses silencing-mediated...
Myeloid-derived suppressor cells (MDSCs) are defined as negative regulators that suppress the immune response through a variety of mechanisms, which usually cluster in cancer, inflammation, and autoimmune diseases. This study aims to investigate correlation between M-MDSCs clinical features diffuse large B-cell lymphoma (DLBCL) patients, well possible accumulation mechanism M-MDSCs. The level is significantly increased newly diagnosed relapsed DLBCL patients. Regarding frequency positively...
The germinal center B-cell (GCB) and activated (ABC) subtypes of diffuse large lymphoma (DLBCL) have a significant difference in prognosis. This study aimed to identify potential hub genes, key pathways involved them.Databases including Gene Expression Omnibus (GEO), Ontology (GO), Kyoto Encyclopedia Genes Genomes (KEGG), STRING were accessed obtain crucial genes associated with the GCB ABC. Then qRT-PCR Western blot experiments performed verify most clinically gene pathway.Three cohort...
Treatment for glaucoma has traditionally been limited to reducing intraocular pressure (IOP). Inhibiting oxidative stress in the trabecular meshwork (TM) is regarded as a new treatment glaucoma; however, effects do not meet expectations. Exploring mechanism by which and antioxidant occur TM cells will offer clues aid development of treatments.In our study, we cultured used H2O2 SOD induce inhibit stress, respectively. Label-free LC-MS/MS quantitative proteomic analysis was conducted analyze...
Chronic lymphocytic leukemia (CLL) is a type of highly heterogeneous mature B-cell malignancy with various disease courses. Although multitude prognostic markers in CLL have been reported, insights into the role super-enhancer (SE)-related risk indicators occurrence and development are still lacking. A (SE) cluster enhancers involved cell differentiation tumorigenesis, one promising therapeutic targets for cancer therapy recent years. In our study, CLL-related super-enhancers training...
Diffuse large B-cell lymphoma (DLBCL) is a highly heterogeneous malignancy with varied outcomes. However, the fundamental mechanisms remain to be fully defined.We aimed identify core differentially co-expressed hub genes and perturbed pathways relevant pathogenesis prognosis of DLBCL.We retrieved raw gene expression profile clinical information GSE12453 from Gene Expression Omnibus (GEO) database. We used integrated bioinformatics analysis genes. The CIBERSORT was also applied predict...
Diffuse large B-cell lymphoma (DLBCL) is the most common non-Hodgkin around world. While R-CHOP has significantly improved patient outcomes, a subset of patients still poor outcome. Here, oncogenic roles cyclin dependent kinase 4/6 (CDK4/6)-Cyclin D (CCND) signaling axis in DLBCL and its potential mechanism were investigated to explore possibility targeting CDK4/6-CCND for therapy. The transcription levels, functional enrichment analysis, mutation prognostic values performed via Oncomine,...
Abstract Chronic lymphocytic leukemia (CLL) is a group of highly heterogeneous mature B cell malignancy with various disease courses and diagnoses. Although there multitude prognostic markers in CLL, insights into the role super-enhancer(SE)-related risk indicators are still lacking. Super-enhancer(SE) novel concept drew recent years which cluster enhancers involved differentiation tumorigenesis ,and one promising therapeutic targets for cancer therapy. The CLL-related super-enhancers...
Abstract Background Chronic lymphocytic leukemia (CLL) is a group of highly heterogeneous mature B cell malignancy with various disease courses and diagnoses. Super-enhancer(SE) novel concept drew in recent years which cluster enhancers involved differentiation tumorigenesis ,and one the promising therapeutic targets for cancer therapy. Although there multitude prognostic markers CLL, insights into role super-enhancer(SE)-related risk indicators are still lacking. Methods The CLL-related...
Abstract Background: Treatment for glaucoma has traditionally been limited to reducing intraocular pressure (IOP). Inhibiting oxidative stress in the trabecular meshwork (TM) is regarded as a new treatment glaucoma; however, effects do not meet expectations. Exploring mechanism by which and antioxidant occur TM cells will offer clues aid development of treatments. Methods results: In our study, we cultured used H 2 O SOD induce inhibit stress, respectively. Label-free LC–MS/MS quantitative...