A5076084797- Fungal Infections and Studies
- Studies on Chitinases and Chitosanases
- Antifungal resistance and susceptibility
- Mycotoxins in Agriculture and Food
- Extracellular vesicles in disease
- Biochemical and Structural Characterization
- Antimicrobial Peptides and Activities
- Plant pathogens and resistance mechanisms
- Genomics and Phylogenetic Studies
- Bacterial Infections and Vaccines
- Metabolomics and Mass Spectrometry Studies
- Protein Hydrolysis and Bioactive Peptides
- Vector-borne infectious diseases
- Galectins and Cancer Biology
Australian Research Council
2025
La Trobe University
2019-2023
Extracellular vesicles (EVs) represent a system for the coordinated secretion of variety molecular cargo including proteins, lipids, nucleic acids and metabolites. They have an essential role in intercellular communication multicellular organisms more recently been implicated host-pathogen inteactions. Study EVs fungal biology has focused on pathogenic yeasts that are major pathogens humans. In this study we expanded investigation to plant pathogens, specifically cotton pathogen Fusarium...
Pathogenic microbes are developing resistance to established antibiotics, making the development of novel antimicrobial molecules paramount. One major resource for discovery antimicrobials is arsenal innate immunity that part first line pathogen defense in many organisms. Gene encoded cationic peptides a constituent immune arsenals. Many these exhibit potent activity vitro. However, hurdle has impeded their use clinic loss at physiological salt concentrations, attributed weakening...
ABSTRACT Background: Fungal extracellular vesicles (EVs) have been implicated in host‐pathogen and pathogen‐pathogen communication some fungal diseases. In depth research into EVs has hindered by the lack of specific protein markers such as those found mammalian that enabled sophisticated isolation analysis techniques. Despite their role EV biogenesis, ESCRT proteins Vps23 (Tsg101) Bro1 (ALIX) are not present cargo. Furthermore, tetraspanin homologs yet to be identified many fungi including...
<title>Abstract</title> <italic>Botrytis cinerea</italic> is a filamentous fungus that infects over 200 species of crops causing grey mold disease with devastating losses to agriculture worldwide. The heavy reliance on synthetic fungicides in the strawberry industry has led emergence fungicide resistance <italic>B. cinerea</italic>. Therefore, understanding fundamental biology first step search for novel antifungals. Although one most serious pathogens (<italic>Fragaria</italic> x...
Extracellular vesicles (EVs) are nano-sized compartments involved in cell communication and macromolecule transport that well characterized mammalian organisms. Fungal EVs virulence-related cargo modulate the host immune response, but most work has been focused on human yeast pathogens. Additionally, study of from filamentous fungi hindered by lack protein markers efficient isolation methods. In this we performed proteomic characterization cotton pathogen Fusarium oxysporum f. sp....
The fungal cell wall is the first point of contact between pathogens and host organisms. It serves as a protective barrier against biotic abiotic stresses signal to that pathogen present. made predominantly carbohydrates glycoproteins, many which serve binding receptors for defence molecules or activate immune responses through interactions with membrane-bound receptors. Plant defensins are large family cationic antifungal peptides protect plants disease. Binding plant defensin NaD1 has been...
Abstract Extracellular vesicles (EVs) from human fungal pathogens have been implicated in virulence, yet little is known about their role the host‐pathogen interaction. Progress has hampered by lack of a specific marker for EVs that can be used to monitor EV isolation and tracking biological systems. Here we report effect SUR7 gene knockout on production, properties, virulence Candida albicans . Sur7 component membrane compartment Can1 (MCC) complex enriched C. other species. MCC plasma...
Fusarium graminearum (F. graminearum) is a filamentous fungus that infects cereals such as corn, wheat, and barley, with serious impact on yield well quality when the grain contaminated mycotoxins. Despite huge of F. food security mammalian health, mechanisms used by to export virulence factors during infection are not fully understood may involve non-classical secretory pathways. Extracellular vesicles (EVs) lipid-bound compartments produced cells all kingdoms transport several classes...
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