A5033832832- Atherosclerosis and Cardiovascular Diseases
- Hormonal Regulation and Hypertension
- Inflammation biomarkers and pathways
- Pregnancy and preeclampsia studies
- Angiogenesis and VEGF in Cancer
- Chronic Myeloid Leukemia Treatments
- Apelin-related biomedical research
- Birth, Development, and Health
- PI3K/AKT/mTOR signaling in cancer
- Bipolar Disorder and Treatment
- Chemotherapy-induced cardiotoxicity and mitigation
- Cardiac electrophysiology and arrhythmias
- Eosinophilic Disorders and Syndromes
- Eicosanoids and Hypertension Pharmacology
- Chronic Lymphocytic Leukemia Research
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Electroconvulsive Therapy Studies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- MicroRNA in disease regulation
- Neurological Disorders and Treatments
Tufts Medical Center
2021-2024
Tufts University
2021-2023
Johns Hopkins Medicine
2017
Johns Hopkins University
2017
Preeclampsia is a syndrome of high blood pressure (BP) with end organ damage in late pregnancy that associated circulating soluble VEGF receptor (sFlt1 [soluble Fms-like tyrosine kinase 1]). Women exposed to preeclampsia have substantially increased risk hypertension after pregnancy, but the mechanism remains unknown, leaving missed interventional opportunity. After preeclampsia, women enhanced sensitivity hypertensive stress. Since smooth muscle cell mineralocorticoid receptors (SMC-MR) are...
BCR-ABL tyrosine kinase inhibitors (TKIs) have dramatically improved survival in Philadelphia chromosome-positive leukemias. Newer TKIs provide superior cancer outcomes but with increased risk of acute arterial thrombosis, which further increases patients cardiovascular comorbidities and mitigates benefits compared to imatinib. Recent studies implicate endothelial cell (EC) damage this toxicity by unknown mechanisms few side-by-side comparisons multiple no available data on impact recently...
Introduction: Tyrosine kinase inhibitors (TKIs) targeting ABL have transformed the treatment of BCR-ABL positive leukemias. First generation imatinib is well tolerated while newer TKIs, ponatinib and nilotinib, are more effective for leukemia but both substantially increase risk acute arterial thrombosis, thereby limiting their clinical benefit over imatinib. Asciminib a new inhibitor with an unknown safety profile. We previously showed that thrombosis in humans also cause toxicity...
Objective: Animal models of atherosclerosis are used extensively to interrogate molecular mechanisms in serial fashion. We tested whether a novel systems biology approach integration preclinical data identifies pathways and regulators human disease. Approach Results: Of 716 articles published ATVB from 1995 2019 using the apolipoprotein E knockout mouse study atherosclerosis, were extracted 360 unique studies which gene was experimentally perturbed impact plaque size or composition analyzed...
Background: Atherosclerosis (athero) inflammation predicts plaque rupture, causing heart attack and stroke. Female protection from stroke is lost with age, implicating estrogen, but by unclear mechanism. Our lab showed that the mineralocorticoid receptor (MR) expressed in endothelial cells (ECs), where it drives male mice inducing NFkB-regulated adhesion molecule ICAM1. Females had less inflamed plaques, unchanged EC-MR-knockout (KO). Hypothesis: We hypothesized EC-estrogen alpha (ER)...
Background: ABL tyrosine kinase inhibitors (TKI) have dramatically improved chronic myeloid leukemia (CML) survival. Due to resistance the first ABL-TKI imatinib (Ima), most patients are treated with newer agents, including ponatinib (Pon). Although Pon improves cancer remission, survival benefit is mitigated by a 4-fold increase in arterial thrombosis. The mechanism of Pon-induced thrombosis and safety Asciminib (Asc), newly approved alternative, not known. CML older notably elevated serum...
Obesity induced endothelial dysfunction contributes to the vascular inflammation. MicroRNAs (miRNAs) are implicated in epigenetic regulation of inflammatory pathways. However, relevant miRNAs microvasculature, and their relation chronic inflammation metabolic poorly understood. Using micro-RNA Seq approach profile microRNAs from cells (ECs) brown adipose tissue (BAT) mice with diet-induced obesity (DIO), we identified microRNA- 485-5p (miR-485-5p) as one most differentially regulated miRNA....
Preeclampsia (PE), a syndrome of high blood pressure (BP) and renal damage in late pregnancy, is associated with increased soluble VEGF receptor (sFlt1) survivors have risk future hypertension cardiovascular disease.Since smooth muscle cell mineralocorticoid (SMC-MR) can be activated by hypertensive stimuli, we hypothesized that sFlt1 exposure during pregnancy may induce post-partum state enhanced vascular sensitivity via SMC-MR activation.A PE model was induced transient viral expression...
Introduction: Animal models of human diseases are used extensively to interrogate molecular mechanisms in a reductionist fashion. We tested whether aggregation and integration preclinical data can identify new causative pathways that faithfully model disease mechanisms. have termed this novel technique, the Preclinical Science Integration Translation (PRESCIANT) method. Methods Results: Data were extracted from 716 manuscripts journal Arteriosclerosis, Thrombosis, Vascular Biology 1995-2019...
Introduction: Animal models are extensively used to interrogate molecular mechanisms of disease. The apolipoprotein E knockout (ApoE-KO) and low-density lipoprotein receptor (LDLR)-KO mouse well established preclinical atherosclerosis. Hypothesis: We hypothesized that integrated analysis data will identify novel signaling pathways regulatory networks driving atherogenesis. Comparison findings between may implicate model-specific Methods: Data were extracted from 716 ApoE KO 422 LDLR...