A5073954560- Marine animal studies overview
- Underwater Acoustics Research
- Arctic and Antarctic ice dynamics
- Animal Vocal Communication and Behavior
- Trypanosoma species research and implications
- Marine and coastal plant biology
- Effects and risks of endocrine disrupting chemicals
- Coral and Marine Ecosystems Studies
- Marine and fisheries research
- Underwater Vehicles and Communication Systems
- Research on Leishmaniasis Studies
- Mercury impact and mitigation studies
- Toxic Organic Pollutants Impact
- DNA Repair Mechanisms
- Water Quality Monitoring Technologies
- Synthesis and Catalytic Reactions
- Species Distribution and Climate Change
- Synthesis and biological activity
- Genetic factors in colorectal cancer
- Morinda citrifolia extract uses
- Microplastics and Plastic Pollution
- Calpain Protease Function and Regulation
- Heavy metals in environment
- Enzyme Production and Characterization
- Cancer Genomics and Diagnostics
Toronto General Hospital
2024
Digital Research Alliance of Canada
2023
Myriad Genetics
2015
University of Southern Maine
2009-2013
University of California, San Francisco
2010
SUMMARY Delphinoids (Delphinidae, Odontoceti) produce tonal sounds and clicks by forcing pressurized air past phonic lips in the nasal complex. It has been proposed that homologous, hypertrophied structures deep-diving sperm whale (Physeter macrocephalus) (Physeteridae, are dedicated to production of clicks. However, volumes diving mammals reduced with increasing ambient pressure, which seems likely influence pneumatic sound at depth. To study depth, we attached ultrasound...
A century after discovering that the Trypanosoma cruzi parasite is etiological agent of Chagas disease, treatment still plagued by limited efficacy, toxicity, and emergence drug resistance. The development inhibitors major T. cysteine protease, cruzain, has been demonstrated to be a promising discovery avenue for this neglected disease. Here we establish nonpeptidic tetrafluorophenoxymethyl ketone cruzain inhibitor substantially ameliorates symptoms acute disease in mouse model with no...
The North Atlantic right whale Eubalaena glacialis (NARW), currently numbering <410 individuals, is on a trajectory to extinction. Although direct mortality from ship strikes and fishing gear entanglements remain the major threats population, reproductive failure, resulting poor body condition sublethal chronic entanglement stress, believed play crucial role in population decline. Using photogrammetry unmanned aerial vehicles, we conducted largest assessment of date, determine if NARWs...
Cetacean sighting data collected under various programmes in Colombian Pacific waters were collated with the goal of assessing distribution and abundance patterns all species occurring exclusive economic zone (EEZ). Distribution maps are presented for 19 one genus based on 603 sightings between 1986 2008. Ordered by frequency, these were: humpback whale (Megaptera novaeangliae); striped dolphin (Stenella coeruleoalba); common bottlenose (Tursiops truncatus); pantropical spotted attenuata);...
Toothed whales (Odontoceti, Cetacea) navigate and locate prey by means of active echolocation. Studies on captive animals have accumulated a large body knowledge concerning the production, reception processing sound in odontocete biosonars, but there is little information about properties use biosonar clicks free-ranging offshore habitats. This study presents first source parameter estimates from two oceanic delphinids, opportunistically foraging Pseudorca crassidens cephalopod eating...
The interplay of natural selection and genetic drift, influenced by geographic isolation, mating systems population size, determines patterns diversity within species. sperm whale provides an interesting example a long-lived species with few barriers to dispersal. Worldwide mtDNA is relatively low, but highly structured among regions social groups, attributed female philopatry. However, it unclear whether this philopatry due or how might vary on worldwide scale. To answer these questions, we...
Culture, a pillar of the remarkable ecological success humans, is increasingly recognized as powerful force structuring nonhuman animal populations. A key gap between these two types culture quantitative evidence symbolic markers-seemingly arbitrary traits that function reliable indicators cultural group membership to conspecifics. Using acoustic data collected from 23 Pacific Ocean locations, we provide certain sperm whale signals exhibit spatial patterns consistent with marker function....
The Indian Ocean Sanctuary was established in 1979 an effort to allow exploited stocks of whales recover from whaling and facilitate benign research. Further information is required establish comprehensive management conservation measures for species within these waters. current study took place the offshore waters Sri Lanka early 2003. During three research cruises conducted between 29 March 17 June 2003 R/V Odyssey covered a total track line 4,480km around island resulting 52 confirmed...
ABSTRACT Unoccupied aerial system (UAS) technologies applied to health assessments of large whales can have positive implications for progressive management. We focused on the collection cetacean respiratory blow samples endocrine, DNA profiling, microbial metabarcoding, and metagenomics analyses, with goal improving management whale populations. Blow were collected from humpback ( Megaptera novaeangliae, n = 109 analyzed), blue Balaenoptera musculus, 21 killer Orcinus orca, 1 sample...
Despite its central position in the Indian Ocean Sanctuary, little is known about offshore cetacean fauna of Maldives. Here we report survey results gathered by R/V Odyssey Maldives during 2003 and 2004 northeast monsoon seasons, provide data on cetaceans from visual acoustic observations. The was conducted over a period 72 days covered 10,915 track line kilometres. main aim to collect biopsy samples sperm whales (Physeter macrocephalus) as part global ocean pollutants. Totals 157 sightings...
Suction-cup-attached biologging tags have led to major advances in our understanding of large whale behaviour. Getting close enough a at sea safely attach tag is limiting factor when deploying these systems. Here we present an uncrewed aerial system (UAS)-based tagging technique for free-swimming whales and provide data on efficacy from field testing blue (
Ocean pollution affects marine organisms and ecosystems as well humans. The International Oceanographic Commission recommends ocean health monitoring programs to investigate the presence of contaminants threatened species use multiple early-warning biomarker approaches.We explored hypothesis that contaminant analyses in skin biopsies sperm whale (Physeter macrocephalus) could reveal geographical trends exposure on an oceanwide scale.We analyzed cytochrome P450 1A1 (CYP1A1) expression (by...
Mismatch repair prevents the accumulation of erroneous insertions/deletions and non-Watson-Crick base pairs in genome. Pathogenic mutations MLH1 gene are associated with a predisposition to Lynch Turcot's syndromes. Although genetic testing for these is available, robust classification variants requires strong clinical functional support. Here, first structure N-terminus human MLH1, determined by X-ray crystallography, described. The shares high degree similarity previously prokaryotic...
The distribution and use of pelagic habitat by sperm whales (Physeter macrocephalus) is poorly understood in the south-eastern Indian Ocean off Western Australia. However, a variety data are available via online portals where records historical expeditions, commercial whaling operations, modern scientific research voyages can now be accessed. Crowdsourcing these allows collation presence-only information animals provides valuable tool to help augment areas low effort. Four sources were...
Rapidly dropping costs and increasing capabilities of robotic systems are creating unprecedented opportunities in the world marine research. Remote sample collection conditions that were once impossible due to expense, location, timing, or risk now becoming a reality. Of particular interest biological research is aspect removing additional stressors form humans equipment from cetacean monitoring. In partnership between Olin College Engineering Ocean Alliance, fleet multirotor unmanned air...
Rapidly dropping costs and increasing capabilities of robotic systems are creating unprecedented opportunities for the world scientific research. Remote sample collection in conditions that were once impossible due to expense, location, timing, or risk now becoming a reality. Of particular interest marine biological research is aspect removing additional stressors form humans equipment from whale monitoring. In partnership between Olin College Engineering Ocean Alliance, multirotor unmanned...
The acoustic ecology of sei whales (Balaenoptera borealis) is poorly understood due to limited direct observation the behavioral context sound production and individual behavior. Suction cup–attached recording tags were deployed on unambiguously assign call types explore behavior this endangered species. Twelve tag deployments resulted in ∼173 h data 1030 calls. Sound included downsweeps three previously undescribed types. Knocks short duration (&lt;1 s), with an average peak frequency...
Abstract The northern Gulf of Mexico has a long history polycyclic aromatic hydrocarbon (PAH) contamination from anthropogenic activities, natural oil seepages, and the 2010 Deepwater Horizon explosion spill. continental shelf same area is known breeding ground for sperm whales (Physeter macrocephalus). To evaluate PAH-DNA damage, biomarker potential cancer risk, we compared skin biopsies collected in 2012 with areas Pacific Ocean 1999–2001. All samples were obtained by crossbow comprised...