A5052697586- Reproductive Biology and Fertility
- Sperm and Testicular Function
- Animal Genetics and Reproduction
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Testicular diseases and treatments
- Genomics, phytochemicals, and oxidative stress
- Reproductive biology and impacts on aquatic species
Tehran University of Medical Sciences
2021-2023
Context Testicular torsion–detorsion results in loss of germ cells and infertility. Pentoxifylline has been shown to prevent tissue damage. Aims To determine the effect pentoxifylline on cell survival induced apoptosis Methods Twenty male mice were divided into four groups five animals each: Control, T1 (Torsion–detorsion + single dose 100 mg/kg Pentoxifylline/IP), T2 daily 20 pentoxifylline/IP for 2 weeks, T/D only). 35th day after torsion–detorsion, left testes all harvested histological...
The process of spermatogonial stem cell cryopreservation (SSCs) in young male cancer survivors is associated with increased reactive oxygen species (ROS), DNA fragmentation, apoptosis, decreased activity, and finally reduced fertility SSCs. Therefore, it necessary to add cryoprotectants the freezing medium minimize injuries cryopreservation. In addition, Nrf2/ARE pathway a main cellular that regulates antioxidant defense system. purpose this study was evaluate cryoprotective effect...
Abstract Background Preserving the spermatogonial stem cells (SSCs) in long periods of time during treatment male infertility using cell banking systems and transplantation is an important issue. Therefore, this study was conducted to develop optimal cryopreservation protocol for SSCs 10 mM pentoxifylline (PTX) as antioxidant basal freezing medium. Methods Testicular torsion - a mouse model long-term infertility- used transplant fresh (n=6), treated with PTX cryopreserved medium (n=6) (n=6)....
Abstract Preserving the spermatogonial stem cells (SSCs) in long periods of time during treatment male infertility using cell banking systems and transplantation is an important issue. Therefore, this study was conducted to develop optimal cryopreservation protocol for SSCs 10 mM pentoxifylline (PTX) as antioxidant basal freezing medium. Testicular torsion - a mouse model long-term infertility- used transplant fresh (n = 6), treated with PTX cryopreserved medium 6) 6). Eight weeks after germ...