A5068783898- Organoselenium and organotellurium chemistry
- Sulfur-Based Synthesis Techniques
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Catalytic Alkyne Reactions
- Catalytic C–H Functionalization Methods
- Synthesis and biological activity
- Crystallography and molecular interactions
- Chemical Synthesis and Reactions
- Organic Chemistry Cycloaddition Reactions
- Cholinesterase and Neurodegenerative Diseases
- Click Chemistry and Applications
- Synthesis and Reactivity of Heterocycles
- Synthesis and Catalytic Reactions
- Synthesis and pharmacology of benzodiazepine derivatives
- Selenium in Biological Systems
- Synthesis and Biological Evaluation
- Organometallic Compounds Synthesis and Characterization
- Catalytic Cross-Coupling Reactions
- Free Radicals and Antioxidants
- Curcumin's Biomedical Applications
- Radical Photochemical Reactions
- Plant-based Medicinal Research
- Cyclopropane Reaction Mechanisms
- Synthesis of Organic Compounds
Universidade Federal de Santa Maria
2012-2024
Universidade Federal de Pelotas
2014-2023
Universidade Federal do Pampa
2023
Weatherford College
2023
Instituto de Ciências Farmacêuticas
2020
RWTH Aachen University
1979-2012
Universidade Federal de Pernambuco
2010
Abstract A simple and rapid method for the selective synthesis of 3‐(organylselanyl)‐1 H ‐indoles 3‐(organylselanyl)imidazo[1,2‐ a ]pyridines catalyzed by CuI/SeO 2 under ultrasound irradiation was developed. This protocol employs diverse range 1 or imidazo[1,2‐ diorganyl diselenides to afford corresponding products selectively in good excellent yields. Moreover, antioxidant activity these compounds evaluated using wide vitro assays, such as 2‐azinobis‐3‐ethylbenzothiazoline‐6‐sulfonic acid...
Organocatalytic enamine–azide [3 + 2] cycloadditions between β-keto sulfones and aryl azides can be performed at room temperature in good to excellent yields of products the presence catalytic amounts pyrrolidine (5 mol %). The proposed organocatalytic methodology was found applicable arylsulfones containing a range substituents. A wide variety also work. Basically, this constitutes remarkably efficient protocol for synthesis novel 1,2,3-triazole compounds.
Abstract We describe here an efficient and regioselective synthesis of arylselanyl anilines by copper‐catalyzed direct arylselenation arylamines. Using a catalytic amount copper iodide in dimethyl sulfoxide at 110 °C under air atmosphere, range was obtained directly from substituted diaryl diselenides moderate to good yields via CH bond cleavage aryl amines. magnified image
We described herein our results on the silver-catalyzed synthesis of diaryl selenides via a cross-coupling reaction diselenides with aryl boronic acids. The methodology is tolerant to electron-donor and electron-withdrawing groups at substrates desired products were obtained in good excellent yields.
The synthesis of several highly functionalized 2,3-dihydroselenophenes from homopropargyl selenides via electrophilic cyclization is described. Electrophiles such as I2, ICl, and PhSeBr were used in a simple process employing CH2Cl2 solvent at room temperature, which gave the cyclized products high yields. 4-Iodo-2,3-dihydroselenophenes obtained by this methodology submitted to dehydrogenation reaction using 2,3-dichloro-5,6-dicyanobenzoquinone (DDQ) give 3-iodoselenophenes....
Therapies for the treatment of pain and inflammation continue to pose a global challenge, emphasizing significant impact on patients’ quality life. Therefore, this study aimed investigate effects 4-(Phenylselanyl)-2H-chromen-2-one (4-PSCO) pain-associated proteins through computational molecular docking tests. A new pharmaceutical formulation based polymeric nanocapsules was developed characterized. The potential toxicity 4-PSCO assessed using Caenorhabditis elegans Swiss mice, its...
We describe here a simple method for the synthesis of 6-arylselanylpurines with antioxidant and anticholinesterase activities, memory improvement effect. This class compounds was synthesized in good yields by reaction 6-chloropurine diaryl diselenides using NaBH4 as reducing agent PEG-400 solvent. Furthermore, were evaluated their vitro acetylcholinesterase (AChE) inhibitor activities. The best AChE assessed on vivo improvement. Our results demonstrated that...
A simple and practical protocol for the synthesis of 3-selanyl-benzo[b]furans mediated by SelectFluor® reagent was developed. This novel methodology provided a greener alternative to generate 3-substituted-benzo[b]furans via metal-free procedure under mild conditions. The intramolecular cyclization reaction carried out employing an electrophilic selenium species generated in situ through between organic diselenides. formation this (RSe-F) confirmed heteronuclear NMR spectroscopy, its...
Abstract We present our results on the cyclization of ( Z )‐chalcogenoenynes mediated by copper(II) salts to afford 3‐halochalcogenophenes in satisfactory yields through an intramolecular 5‐ endo‐dig cyclization. The methodology was carried out using CuCl 2 at 50 °C or CuBr room temperature under ambient atmosphere. reaction took place very mild conditions and tolerated considerable functionality. One 3‐bromo‐selenophene derivative applied as a substrate palladium‐catalyzed cross‐coupling...
Here we present our results in palladium cross-coupling reaction of aryl boronic acids with 4-iodo-2,3-dihydroselenophene derivatives. The cross-coupled products were obtained satisfactory yields. A dehydrogenation of4,5-diphenyl-2,3-dihydroselenophene was activated by DDQ and the 2,3-diarylselenophene good yield. Regarding antioxidant activity, selenophene derivative 3a effective counteracting lipid protein oxidation as well scavenging ABTS radical. findings study indicate that is a...
Results on the synthesis of tetrahydroselenophene derivatives from 1-butylseleno-4-alkynes by electrophilic cyclization using iodine as source are presented. This methodology was carried out via a simple process under mild reaction conditions providing cyclized products in high yields. Electrophilic sources, such PhSeBr, CuCl2, and CuBr2, were also used this study. The tetrahydroselenophenes obtained protocol submitted to cyanation, Suzuki, Ullmann cross-coupling reactions afford good yields...
Abstract Copper(II) halide mediated cyclization of homopropargyl chalcogenides gave three types chalcogenophene derivatives. Selective product formation was achieved by controlling solvent, temperature, and atmosphere. By using CuBr 2 1,2‐dichloroethane at room temperature under ambient atmosphere, 4‐bromo dihydroselenophene derivatives were obtained, whereas reflux selectively 2‐substituted selenophenes. When replaced dimethylacetamide, 3‐halo‐selenophenes obtained exclusively. The...
Abstract We describe herein an alternative method for the synthesis of 2‐aryl‐(3‐organochalcogenyl)thieno[2,3‐ b ]pyridines through electrophilic cyclization 3‐(arylethynyl)‐2‐(alkylthio)pyridines promoted by species organochalcogen compounds. These were generated in situ oxidative cleavage chalcogen‐chalcogen (Se, Te) bond diorganyl dichalcogenides using Oxone® ethanol as solvent open‐flask at 78 °C. The protocol allowed highly substituted thieno[2,3‐ starting from several and...
A total of thirty-four 3-selanylimidazopyridines were easily prepared in 50–94% yields using bench stable arylseleninic acids as a selenium source.
This review describes the recent advances in photocatalyzed reactions to form new carbon–sulfur and carbon–selenium bonds. With a total of 136 references, which 81 articles are presented, authors introduce five sections an updated picture state art light-promoted synthesis organochalcogen compounds (from 2019 present). The sulfides by direct sulfenylation C–C π-bonds; sulfones; activation Csp2–N bond formation Csp2–S bonds; thiol ester, thioether thioacetal; organoselenium discussed, with...