A5074985193- Endometrial and Cervical Cancer Treatments
- Ovarian cancer diagnosis and treatment
- Uterine Myomas and Treatments
- Endometriosis Research and Treatment
- Cancer, Lipids, and Metabolism
- Cervical Cancer and HPV Research
- Pelvic floor disorders treatments
- Pelvic and Acetabular Injuries
- Colorectal and Anal Carcinomas
- Management of metastatic bone disease
- Anorectal Disease Treatments and Outcomes
- Sarcoma Diagnosis and Treatment
- Cellular Mechanics and Interactions
- Epigenetics and DNA Methylation
- Cancer, Hypoxia, and Metabolism
- Liver Disease Diagnosis and Treatment
- Reproductive Biology and Fertility
- Nanoparticle-Based Drug Delivery
- Gold and Silver Nanoparticles Synthesis and Applications
- Toxic Organic Pollutants Impact
- Bone Tissue Engineering Materials
- Lymphatic System and Diseases
- Radiomics and Machine Learning in Medical Imaging
- Carcinogens and Genotoxicity Assessment
- Gynecological conditions and treatments
Botswana Geoscience Institute
2025
BGI Research
2025
China Medical University
2014-2024
China Medical University Hospital
2014-2024
China Medical University
2006-2024
Asia University
2021-2024
Stem Cell Technology (Taiwan)
2018
National Yang Ming Chiao Tung University
2004-2016
Taipei Veterans General Hospital
2016
National Chung Hsing University
2014
Targeting androgen receptor may prevent hepatitis B virus–induced liver cancer.
To assess the ability of gold nanoparticles (GNPs) to act as a size-dependent carrier, synthetic peptide resembling foot-and-mouth disease virus (FMDV) protein was conjugated GNPs ranging from 2 50 nm in diameter (2, 5, 8, 12, 17, 37, and nm). An extra cysteine added C-terminus FMDV (pFMDV) ensure maximal conjugation GNPs, which have high affinity for sulfhydryl groups. The resultant pFMDV–GNP conjugates were then injected into BALB/c mice. Immunization with pFMDV–keyhole limpet hemocyanin...
The anti-proliferation effect of caffeic acid (3,4-dihydroxycinnamic acid), isolated from Ocimum gratissimum Linn, on human cervical cancer cells (HeLa cells) was examined to elucidate the associated mechanism and death mode.Flow cytometry showed that treatment results in dramatically increased apoptosis HeLa cells. Western blot analysis revealed activates various processed caspases.Caffeic significantly reduced proliferation a concentration-dependent manner. Morphological evidence...
Breast and cervical cancer are the most common cancers affecting women. The symptom distresses experienced by survivors critical factors influencing their quality of life (QOL). This study investigated QOL breast survivors, physical, psychological social conditions.The participants were older than 20 years, had been diagnosed with or for more 2 completed treatment. survey incorporated questionnaires developed European Organization Research Treatment Cancer a self-designed questionnaire.The...
Cervical cancer ranks as the fourth leading cause of death in women worldwide. In Taiwan, although universal health insurance system has achieved 99.9% coverage and ensured easy access to medical care, some cervical patients continue delay initiation definitive treatment after diagnosis. This study focused on who delayed for at least 4 months, examined characteristics, related factors, survival these patients. Data with a new confirmed diagnosis by International Federation Gynecology...
Survivin is a novel inhibitor of apoptosis and expressed during fetal development in cancer tissues, but its expression has not been reported normal adult tissues or benign diseases. We investigated survivin gene protein tumor-like disease, endometriosis, correlated them with invasive phenotype endometriotic tissues. Gene levels survivin, matrix metalloproteinase (MMP)-2, MMP-9, membrane type 1 (MT1)-MMP 63 pigmented nonpigmented surgically obtained from 35 women endometriosis were compared...
Abstract We aimed to determine whether PAX 1/ SOX 1 methylation could be translated clinical practice for cervical neoplasia detection when used alone and in combination with current cytology‐based Pap screening. conducted a multicenter case–control study 11 medical centers Taiwan from December 2009 November 2010. Six hundred seventy‐six patients were included the analysis, including 330 training set 346 testing set. Multiplex quantitative methylation‐specific polymerase chain reaction ( PCR...
Macrophages play an important role in modulating the immune function of human body, while foam cells differentiated from macrophages with subsequent fatty streak formation a key atherosclerosis. We hypothesized that nanotopography modulates behavior and without bioactive agent. In present study, nanodot arrays ranging 10- to 200-nm were used evaluate growth cells. quantitative analysis, cell adhesion area increased 50-nm compared flat surface, it decreased 100- arrays. A similar trend was...
Ovarian clear cell carcinoma has a poor prognosis in comparison with other pathological types of epithelial ovarian carcinoma. It also relative resistance to first-line platinum-based chemotherapy great risk recurrence. We report case recurrent status after left salpingo-oophorectomy (fertility-sparing debulking operation) and six courses adjuvant (paclitaxel (175 mg/m2)/carboplatin (AUC 6)). However, two years diagnosis, elevated CA-125 accompanied by an intrapelvic mass was noted. Uterine...
The correlation between vascular endothelial growth factor (VEGF)-C gene expression and in vitro invasive activity matrix metalloproteinase (MMP)-2 or 9 proteolytic 11 cervical carcinoma cell lines, was investigated. Immunohistochemical of VEGF-C 52 tissues also correlated with tumor aggressiveness respect to clinicopathologic features, vascularity, MMP-2 patient outcome. Expression mRNA differed remarkably among the lines there a statistical number invaded cells (p = 0.0009) < 0.05)....
Abstract Purpose: To investigate the biological correlation between vascular endothelial growth factor (VEGF)-C expression and invasive phenotype in ovarian carcinomas. Experimental Design: Gene protein levels of VEGF-C 10 carcinoma cell lines were correlated with activity cells. The immunohistochemical tumor aggressiveness 73 carcinomas was also examined respect to clinicopathologic features patient outcome. Results: gene differed remarkably among lines, there a statistical expression,...
We explored the size-dependent impairment of cognition in mice caused by injection gold nanoparticles (GNPs). GNPs 17 and 37 nm diameter were injected intraperitoneally into BALB/c at doses ranging from 0.5 to 14.6 mg kg − 1. ICP-MS was performed on brain tissue collected 1, 14 21 days after injection. A passive-avoidance test day 21. Monoamine levels determined The microscopic distribution hippocampus examined using coherent anti-Stokes Raman scattering (CARS) microscopy transmission electron (TEM).