A5051082712- Antimicrobial Resistance in Staphylococcus
- Nosocomial Infections in ICU
- Bacterial Identification and Susceptibility Testing
- Urinary Tract Infections Management
- Pneumonia and Respiratory Infections
- Geriatric Care and Nursing Homes
- Antibiotic Use and Resistance
- Antibiotic Resistance in Bacteria
- Infective Endocarditis Diagnosis and Management
- Patient Satisfaction in Healthcare
- Emergency and Acute Care Studies
- Antibiotics Pharmacokinetics and Efficacy
- Streptococcal Infections and Treatments
- Bacterial Infections and Vaccines
- Clostridium difficile and Clostridium perfringens research
- Infection Control in Healthcare
- Dysphagia Assessment and Management
- Sepsis Diagnosis and Treatment
- Surgical site infection prevention
- Tuberculosis Research and Epidemiology
- Respiratory viral infections research
- Oral microbiology and periodontitis research
- Monoclonal and Polyclonal Antibodies Research
- Respiratory and Cough-Related Research
- Healthcare cost, quality, practices
Jacobs (United Kingdom)
2025
University at Buffalo, State University of New York
2008-2023
Williams (United States)
2022
Peninsula Research
2021
Ormond (United States)
2021
Buffalo State University
2012
Buffalo Psychiatric Center
2012
Erie County Medical Center
1998-2009
Office of Infectious Diseases
2003
Czech Academy of Sciences, Institute of Microbiology
2003
Staphylococcus aureus bacteremia is associated with substantial morbidity. Recurrence common, but incidence and risk factors for recurrence are uncertain. The emergence of methicillin resistance the ease administering vancomycin, especially in patients who have renal insufficiency, led to reliance on this drug assumption that it as effective β-lactam antibiotics, an remains open debate. We initiated a multicenter, prospective observational study 6 university hospitals enrolled 505...
To assess the prevalence of oral colonization by respiratory pathogens in a group ICU patients, with specific attention to dental plaque and mucosa.Prospective, nonrandomized study age-matched controls.Medical tertiary-care Veterans Affairs Medical Center school outpatient preventive dentistry clinic.Nonconsecutive, unselected patients admitted medical during 2-month period; controls were seen for first time clinic.None.Oral hygienic status was assessed both groups using semiquantitative...
(See the commentary by Moro, on pages 978-980 .) Infection surveillance definitions for long-term care facilities (ie, McGeer Criteria) have not been updated since 1991. An expert consensus panel modified these basis of a structured review literature. Significant changes were made to criteria defining urinary tract and respiratory infections. New added norovirus gastroenteritis Clostridum difficile
Our objectives were to determine the incidence of endocarditis in patients whose Staphylococcus aureus bacteremia was community-acquired, related hemodialysis, or hospital-acquired; assess clinical factors that would reliably distinguished between S. and endocarditis; emergence methicillin-resistant (MRSA) as a cause examine risk for mortality with endocarditis. We conducted prospective observational study 6 university teaching hospitals; we evaluated 505 consecutive bacteremia. Thirteen...
Bacterial pneumonia is a prevalent and costly infection that significant cause of morbidity mortality in patients all ages. The continuing emergence antibiotic-resistant bacteria (e.g., penicillin-resistant pneumococci) suggests bacterial will assume increasing importance the coming years. Thus, knowledge pathogenesis of, risk factors for, critical to development strategies for prevention treatment these infections. adults result aspiration oropharyngeal flora into lower respiratory tract...
Abstract Introduction Dental plaque biofilms are colonized by respiratory pathogens in mechanically-ventilated intensive care unit patients. Thus, improvements oral hygiene these patients may prevent ventilator-associated pneumonia. The goal of this study was to determine the minimum frequency (once or twice a day) for 0.12% chlorhexidine gluconate application necessary reduce colonization 175 intubated trauma unit. Methods A randomized, double-blind, placebo-controlled clinical trial tested...
Journal Article A Subtyping System for Nontypable Haemophilus influenzae Based on Outer-Membrane Proteins Get access Timothy F. Murphy, Murphy From the Division of Infectious Diseases, School Medicine, State University New York at Buffalo, Search other works by this author on: Oxford Academic PubMed Google Scholar Kathleen C. Dudas, Dudas Joseph M. Mylotte, Mylotte Michael A. Apicella The Volume 147, Issue 5, May 1983, Pages 838–846, https://doi.org/10.1093/infdis/147.5.838 Published: 01...
We performed a retrospective study of large cohort patients who had episodes Staphylococcus aureus bacteremia (SAB) from January 1995 through February 1999 at 1 medical center to identify predictors 30-day mortality in SAB. Among 293 with SAB, 68 died (23.2%) within 30 days onset. There was no significant difference associated treatment vancomycin, beta-lactam, or miscellaneous group antimicrobial agents (P=.180). By logistic regression, an acute physiology score (a component the and chronic...
To improve outcomes for cognitively impaired and delirious older adults.Pretest, posttest.A university-affiliated hospital.Physicians nurses in the emergency department (ED) on an acute geriatric unit (AGU).Multifactorial targeted to processes of care adults admitted medicine service from ED.Prevalence delirium, admission AGU, psychotropic medication use, hospital length stay.Patient characteristics did not differ between baseline two outcome cohorts 4 9 months postintervention. Prevalence...
This study sought to reevaluate the epidemiology of bloodstream infection in nursing home residents. The records 166 residents admitted an urban, public, university-affiliated hospital with 169 episodes between January 1997 and April 2000 were retrospectively reviewed. most common organisms isolated Escherichia coli (27% isolates), Staphylococcus aureus (18%; 29% methicillin-resistant strains), Proteus mirabilis (13%). There was minimal resistance quinolones third-generation cephalosporins...
OBJECTIVES : To evaluate the predictability of a pneumonia prognosis index in nursing home residents with and to use account for acute severity before comparing short‐term outcome treated intravenous antibiotic therapy two different settings: an inpatient geriatrics unit DESIGN A retrospective chart review 158 episodes home‐acquired initially antibiotics; 100 were service (AGS), 58 completely (Nursing Home group) SETTING The AGS is 20‐bed within 400‐bed, public, university‐affiliated...
Journal Article Identification of a Specific Epitope Haemophilus influenzae on 16,600-Dalton Outer Membrane Protein Get access Timothy F. Murphy, Murphy From the Division Infectious Diseases, School Medicine, State University New York at Buffalo, Search for other works by this author on: Oxford Academic PubMed Google Scholar M. Bud Nelson, Nelson Kathleen C. Dudas, Dudas Joseph Mylotte, Mylotte Michael A. Apicella The Volume 152, Issue 6, December 1985, Pages 1300–1307,...
Medicare stopped reimbursing United States hospitals for several complications or comorbidities developed during hospitalizations effective 1 October 2008. The Centers and Medicaid Services selected high-cost high-frequency events from the National Quality Forum's list of "never events" inclusion in this reimbursement change. Several these and/or are nosocomial infections, a significant proportion which not likely to be preventable. Attempts eliminate may have unwanted clinical economic...
To describe the findings of a retrospective study treatment nursing home-acquired pneumonia (NHAP) in 11 homes one community and development guideline for NHAP using data from study.A chart review 239 episodes occurring between November 1, 1997, April 30, 1998, was performed. Data regarding antibiotic were used to revise developed by authors. Further refinements made based on small group discussions with physicians nurse practitioners caring population.Residents identified among populations...
To compare two strategies for implementing guidelines nursing home-acquired pneumonia (NHAP) and to measure outcomes associated with treatment in accordance the guidelines.Randomized controlled trial.Ten skilled facilities (SNFs) from a single metropolitan area.Patients an episode of acquired more than 3 days after admission SNF (N = 350): 226 preintervention episodes 116 postintervention episodes.Multi-faceted education intervention including small-group consensus process limited physicians...
OBJECTIVES : To derive a prediction model of 30 day mortality for nursing home‐acquired pneumonia (NHAP) based on factors that can be readily identified by home staff at the time diagnosis and to apply management issues related NHAP including clarifying importance prepneumonia functional status as predictor outcome NHAP. DESIGN This was retrospective chart review 378 episodes treated in or hospital during two periods: November 1997 April 1998 1999. SETTING Eleven homes greater Buffalo, NY...
OBJECTIVES: To determine the frequency of aspiration pneumonitis in nursing home residents with an initial diagnosis pneumonia and to compare clinical characteristics, management, outcome those pneumonia. DESIGN: Retrospective chart review. SETTING: Hospital geriatric unit for residents. PARTICIPANTS: Nursing admitted inpatient suspected between May 1999 April 2001 (n = 195 episodes). MEASUREMENTS: Aspiration events were defined as definite (witnessed or unwitnessed) suspected. was...
The objectives of this study were to define the epidemiology nosocomial bacterial colonization and infection predictors among a cohort (n=423) admissions an acute rehabilitation unit. Overall, methicillin-resistant Staphylococcus aureus (MRSA) enterococci most commonly identified colonizing organisms. Escherichia coli Pseudomonas aeruginosa gram-negative bacilli. During 70 (16.5%) 423 hospitalizations in unit, 94 infections occurred. common those urinary tract (30% infections) or surgical...
Abstract A retrospective review of microbiology records revealed 19 documented episodes M. morganii bacteremia in 18 patients at a Veterans Administration hospital during 5.5 year period. Thirteen bacteremias were related to nosocomial infections; 11 the 13 occurred surgical patients. Nine with had received recent therapy beta-lactam antibiotic. The most common source was postoperative wound infection (seven episodes). Only one episode urinary tract infection. Retrospective analysis showed...
Little is known regarding killing activity of vancomycin against methicillin (meticillin)-resistant Staphylococcus aureus (MRSA) in pneumonia since the extent penetration into epithelial lining fluid (ELF) has not been definitively established. We evaluated impact ELF on bacterial and resistance by simulating a range exposures (24-h free drug area under concentration-time curve [fAUC24]/MIC) using an vitro pharmacodynamic model population-based mathematical modeling. A high-dose,...