A5027622376- Bioactive natural compounds
- Natural product bioactivities and synthesis
- Sirtuins and Resveratrol in Medicine
- Bioactive Compounds and Antitumor Agents
- Influenza Virus Research Studies
- Microbial Natural Products and Biosynthesis
- Bioactive Natural Diterpenoids Research
- Plant biochemistry and biosynthesis
- X-ray Diffraction in Crystallography
- Pharmacological Effects of Natural Compounds
- Genomics, phytochemicals, and oxidative stress
- Biological Activity of Diterpenoids and Biflavonoids
- Crystallization and Solubility Studies
- Autophagy in Disease and Therapy
- ATP Synthase and ATPases Research
- Metabolism, Diabetes, and Cancer
- Curcumin's Biomedical Applications
- Enzyme function and inhibition
- Ginseng Biological Effects and Applications
- Phytochemistry and Bioactive Compounds
- Protein Tyrosine Phosphatases
- Phytochemistry and Biological Activities
- Natural Compound Pharmacology Studies
- Antimicrobial Peptides and Activities
- Calcium signaling and nucleotide metabolism
VNU University of Science
2023
University of Bristol
2019-2022
University of Copenhagen
2016-2019
National Library of Vietnam
2013-2019
Institute of Medicinal Plant Development
2017
Seoul National University
2013-2016
Chosun University
2008-2013
Chungnam National University
2010
Hanoi University of Pharmacy
2010
Vietnam Academy of Science and Technology
2009
As part of an ongoing study focused on the discovery anti-influenza agents from plants, four new (1-4) and 10 known (5-14) C-methylated flavonoids were isolated a methanol extract Cleistocalyx operculatus buds using influenza H1N1 neuraminidase inhibition assay. Compounds 4, 7, 8, 14, with chalcone skeleton, showed significant inhibitory effects viral neuraminidases two strains, H9N2. Compound 4 strongest activity against novel (WT) oseltamivir-resistant (H274Y mutant) expressed in 293T...
The transition from a chemotherapy-responsive cancer to chemotherapy-resistant one is accompanied by increased expression of multidrug resistance 1 (MDR1, <i>p</i>-glycoprotein), which plays an important role in the efflux target cell many anticancer agents. We recently showed that Forkhead box-containing protein O subfamily (FoxO1) key regulator <i>MDR1</i> gene transcription. Because nuclear localization FoxO1 regulated silent information two ortholog (SIRT1) deacetylase, we wondered...
Phytochemical study on a methanol-soluble extract of the leaves persimmon (Diospyros kaki) resulted in isolation two new ursane-type triterpenoids, 3α,19α-dihydroxyurs-12,20(30)-dien-24,28-dioic acid (1) and 3α,19α-dihydroxyurs-12-en-24,28-dioic (2), together with 12 known ursane- oleanane-type triterpenoids (3−14). Triterpenoids 3β-hydroxy group were found to inhibit protein tyrosine phosphatase 1B (PTP1B) activity, IC50 values ranging from 3.1 ± 0.2 18.8 1.3 μM, whereas those 3α-hydroxy...
AMP-activated protein kinase (AMPK) has been proposed as a therapeutic target for the treatment of metabolic syndrome including obesity and type-2 diabetes. The bioassay-guided fractionation an EtOAc-soluble extract stem bark Erythrina abyssinica led to isolation new coumestan, erythribyssin N (1), two benzofurans, F (2) H (3), along with five known compounds (4−8). When tested their stimulatory effects on AMPK activity at concentration 10 μM, 4 5 showed potent activation, while 1, 2, 7 had...
Four new terpenylated coumarins (1–4) were isolated from the stem bark of Ailanthus altissima by bioactivity-guided fractionation using an in vitro SIRT1 deacetylation assay. Their structures identified as (2′R,3′R)-7-(2′,3′-dihydroxy-3′,7′-dimethylocta-6′-enyloxy)-6,8-dimethoxycoumarin (1), 6,8-dimethoxy-7-(3′,7′-dimethylocta-2′,6′-dienyloxy)coumarin (2), (2′R,3′R,6′R)-7-(2′,3′-dihydroxy-6′,7′-epoxy-3′,7′-dimethyloctaoxy)-6,8-dimethoxycoumarin (3), and...
Four new ent-kaurane diterpenoids (1–4) were isolated from the leaves of Croton tonkinensis by bioactivity-guided fractionation using an in vitro osteoblast differentiation assay. Their structures identified as ent-11β-acetoxykaur-16-en-18-ol (1), ent-11α-hydroxy-18-acetoxykaur-16-ene (2), ent-14β-hydroxy-18-acetoxykaur-16-ene (3), and ent-7α-hydroxy-18-acetoxykaur-16-ene (4). Compounds 1–4 significantly increased alkaline phosphatase activity osteoblastic gene promoter activity. 1–3 also...
P-type ATPases catalyze the active transport of cations and phospholipids across biological membranes. Members this large family are involved in a range fundamental cellular processes. To date, substantial number ATPase inhibitors have been characterized, some which used as drugs. In work library natural compounds was screened we first identified curcuminoids plasma membrane H+-ATPases plant fungal cells. We also found that commercial curcumins contain several curcuminoids. Three these were...