A5044095265- Epigenetics and DNA Methylation
- Gestational Diabetes Research and Management
- Tendon Structure and Treatment
- Osteoarthritis Treatment and Mechanisms
- Pregnancy and preeclampsia studies
- Global Public Health Policies and Epidemiology
- Gear and Bearing Dynamics Analysis
- Exercise and Physiological Responses
- Peroxisome Proliferator-Activated Receptors
- Diet, Metabolism, and Disease
- Knee injuries and reconstruction techniques
- Muscle metabolism and nutrition
- Child and Adolescent Health
- Plant and Fungal Interactions Research
- Bacteriophages and microbial interactions
- Plant Virus Research Studies
- Birth, Development, and Health
- Sports injuries and prevention
- Liver Disease Diagnosis and Treatment
- Obesity, Physical Activity, Diet
Stellenbosch University
2018-2023
South African Medical Research Council
2018-2023
University of the Western Cape
2018
University of Cape Town
2011-2013
Sports Science Institute of South Africa
2011-2013
Summary COL5A1 encodes for the α1 chain of type V collagen, an important regulator fibril assembly in tendons, ligaments and other connective tissues. A polymorphism (rs12722) within functional 3′‐untranslated region (UTR) has been shown to associate with chronic Achilles tendinopathy exercise‐related phenotypes. The 3′‐UTR contains several putative cis‐acting elements including a Hsa‐miR‐608 binding site. aim this study was determine whether previously uncharacterized polymorphisms or...
Recent skin metagenomic studies have investigated the harbored viral diversity and its possible influence on healthy microbial populations, tried to establish global patterns of skin-phage evolution. However, detail associated with phages that potentially play a role in health has not been investigated. While metagenome -metavirome indicated virome is highly site specific shows marked interpersonal variation, they assessed presence/absence individual phages. Here, we took semi-culture...
Non-communicable diseases contribute significantly to the disease burden within South Africa. In most unequal of societies in world, poverty and socio-economic disparity are amongst greatest obstacles facing Africans, impacting heavily on health care. Adverse socio-environmental factors, especially those experienced during early life, can, through neurobiological epigenetic mechanisms, developmentally programme outcome obesity, diabetes, cardiovascular mental disorders adulthood. this...
Metabolic risk varies according to body mass index (BMI), fat distribution and ethnicity. In recent years, epigenetics, which reflect gene-environment interactions have attracted considerable interest as mechanisms that may mediate differences in metabolic risk. The aim of this study was investigate DNA methylation abdominal gluteal subcutaneous adipose tissues normal-weight obese black white South African women. Body composition assessed using dual-energy x-ray absorptiometry computerized...
DNA methylation is increasingly recognized as a potential biomarker of metabolic disease. However, there limited information on the impact human immunodeficiency virus (HIV) infection candidacy to serve molecular biomarkers. This study investigated effect HIV patterns in peripheral blood South African women with (n = 95) or without 191) gestational diabetes mellitus (GDM). levels at eight CpG sites adiponectin gene (ADIPOQ) promoter were measured using bisulfite conversion and...
Previously we reported that a high fat, sugar (HFHS) diet induced adiposity, hyperinsulinaemia, hyperleptinaemia, hypertriglyceridaemia and increased liver mass in male Wistar rats. In the present study, mechanisms underlying were further elucidated by assessing hepatic lipid accumulation expression methylation status of key metabolic genes using histology, quantitative real-time PCR pyrosequencing, respectively. The HFHS steatosis, triglycerides (1.8-fold, p < 0.001), sterol regulatory...