A5016009615- Neuroinflammation and Neurodegeneration Mechanisms
- Alzheimer's disease research and treatments
- Phagocytosis and Immune Regulation
- Barrier Structure and Function Studies
- Histone Deacetylase Inhibitors Research
- Neurological Disease Mechanisms and Treatments
- Immune cells in cancer
- Medicinal Plants and Neuroprotection
Broad Institute
2023-2024
Boston Children's Hospital
2023-2024
John Wiley & Sons (Germany)
2023
Moss Landing Marine Laboratories
2023
Hudson Institute
2023
New York Academy of Sciences
2023
Salk Institute for Biological Studies
2021-2022
Dense-core plaques, whose centers contain highly polymerized and compacted aggregates of amyloid β peptides, are one the two defining histopathological features Alzheimer’s disease. Recent findings indicate that these plaques do not form spontaneously but instead constructed by microglia, tissue macrophages central nervous system. We discuss cellular, structural, functional, gene expression criteria which microglial assembly dense-core in brain parallels construction granulomas other...
Many apoptotic thymocytes are generated during the course of T cell selection in thymus, yet machinery through which these dead cells recognized and phagocytically cleared is incompletely understood. We found that TAM receptor tyrosine kinases Axl Mer, co-expressed by a specialized set phagocytic thymic macrophages, essential components this machinery. Mutant mice lacking Mer exhibited marked accumulation time autoreactive nonreactive normally die. Unexpectedly, double mutants also displayed...
Recurrent seizure is a common comorbidity in early-stage Alzheimer’s disease (AD) and may contribute to AD pathogenesis cognitive decline. Similarly, many mouse models of that overproduce amyloid beta are prone epileptiform seizures result early sudden death. We studied one such model, designated APP/PS1 , found mutation the TAM receptor tyrosine kinase (RTK) Mer or its ligand Gas6 greatly exacerbated Lethality was tied violent appeared initiate dentate gyrus (DG) hippocampus, where plays an...
Here, we describe a highly adaptable toolbox for characterizing and analyzing molecular histopathological changes in Alzheimer's disease (AD) mouse models. We detail optimized streamlined approaches from sample preparation to image analysis facilitate reproducible analyses. also the extraction measurement of soluble Aβ level by sandwich ELISA cortex hippocampus AD models before after plaque deposition. Finally, outline steps quantification using Imaris ImageJ. For complete details on use...