A5085001694- Neuroscience and Neuropharmacology Research
- Cholinesterase and Neurodegenerative Diseases
- Neurotransmitter Receptor Influence on Behavior
- Nicotinic Acetylcholine Receptors Study
- Aging, Health, and Disability
- Patient-Provider Communication in Healthcare
- Nursing care and research
- Dialysis and Renal Disease Management
- Child Nutrition and Feeding Issues
- Tryptophan and brain disorders
- Pressure Ulcer Prevention and Management
- Family and Patient Care in Intensive Care Units
- Stress Responses and Cortisol
- Phosphodiesterase function and regulation
- Health and Lifestyle Studies
- Patient Satisfaction in Healthcare
- Pregnancy and preeclampsia studies
- Palliative Care and End-of-Life Issues
- Dental Health and Care Utilization
- Memory and Neural Mechanisms
- Ethics and bioethics in healthcare
- Central Venous Catheters and Hemodialysis
- Neuroendocrine regulation and behavior
- Diabetic Foot Ulcer Assessment and Management
- Nursing Diagnosis and Documentation
Gobierno del Principado de Asturias
2022
Instituto de Investigación Sanitaria del Principado de Asturias
2016-2022
Hospital Universitari i Politècnic La Fe
2020-2021
Universidad de Navarra
2004-2015
Fundación Hospital de Jove
2007-2013
Universidade Federal de São Paulo
2011
Universidad Español
2010
Pontifícia Universidade Católica de Minas Gerais
1978
Abstract The involvement of the cholinergic system in learning and memory together with cognitive enhancing properties 5‐HT 6 receptor antagonists led us to study relationship between receptors neurotransmission. A selective lesion, induced by injection immunotoxin 192‐IgG‐Saporin into nucleus basalis magnocellularis, failed alter density mRNA or protein expression deafferentated frontal cortex, suggesting that are not located on neurons. antagonist SB‐357134 (0.001–1 µ m ) a...
Background and purpose: The beneficial effect of 5‐HT 6 receptor antagonism in cognition remains controversial. This study has been undertaken to reassess the enhancing properties acute vs subchronic treatment with selective antagonist SB‐271046 unimpaired rats, as well against scopolamine (cholinergic‐) or MK‐801 (glutamatergic‐mediated) deficits. Experimental approach: Morris water maze was used, measuring behaviour acquisition retention, swim speed. Other behavioural measures included...
We studied the hypothesis that disturbances in 5-HT6 receptor function temporal cortex may contribute to clinical symptoms of Alzheimer's disease (AD). density and 5-HT levels were significantly decreased a cohort AD patients prosp
The cholinergic system has been widely implicated in cognitive processes and loss is a classical hallmark Alzheimer disease. Increasing evidence supports role of the serotonergic cognition, possibly through modulation activity. We compared selective denervation by administration immunotoxin 192 IgG-saporin nucleus basalis Meynert (NBM) with intracerebroventricular (ICV) lesions basal forebrain male rats 7 days after lesioning. NBM induced significant changes markers frontal cortex, whereas...
A growing body of evidence supports the use serotonin 5-HT6 receptor antagonists as a promising mechanism for treating cognitive dysfunction. We evaluated expression and associated biochemical mechanisms in hippocampus rats that had been trained Morris water maze (MWM), spatial learning task. Training MWM induces down-regulation protein mRNA expression. The procedure or administration selective antagonist SB-271046 induced an increase pCREB1 levels while CREB2 were significantly reduced....
To develop a questionnaire aimed to measure the quality of advance care planning process in healthcare professionals and assess its psychometric quality.Instrumental validation study.primary centers outpatients clinics from general hospitals Ferrol, Ourense, Monforte-Lugo Health Area V Service Asturias.physicians nurses. Phases: (1) design first version using Delphi technique; (2) construction second 21 items, after judges' agreement Kendall's W test; (3) pilot study: internal consistency...
Alzheimers disease (AD) is a chronic progressive disorder characterized by dementia, but often featuring behavioral and psychological syndromes (BPSD), such as depression, overactivity, psychosis or aggressive behavior. Traditional treatments for BPSD are neuroleptics sedatives, which not devoid of serious adverse effects. Neurochemically, the classical hallmark AD disruption basal forebrain cholinergic pathways consequent cortical denervation neocortex hippocampus. However, it conceivable...