A5078972891- Oxidative Organic Chemistry Reactions
- Marine Toxins and Detection Methods
- Synthetic Organic Chemistry Methods
- Microbial Natural Products and Biosynthesis
- Polysaccharides Composition and Applications
- Blood properties and coagulation
- Marine Sponges and Natural Products
- Food Science and Nutritional Studies
- Crystallization and Solubility Studies
- Bacterial Identification and Susceptibility Testing
- Proteins in Food Systems
- Antibiotic Resistance in Bacteria
- X-ray Diffraction in Crystallography
Kitasato University
2017-2022
αs1-Casein and soybean globulins were polymerized gelatinized by Ca2+-independent transglutaminase that was isolated from the culture filtrate of a microorganism thought to belong Streptoverticillium sp. actinomycetes. This enzyme such albumins as bovine serum albumin, human albumin conalbumin in presence dithiothreitol. Rabbit myosin present emzyme but actin not. An RP-HPLC analysis after enzymic digestion asl -casein showed existence £-(y-Glu)Lys bond. Thus, it confirmed polymerization...
Tetrodotoxin (TTX) is a neurotoxic natural product that an indispensable probe in neuroscience, biosynthetic and ecological enigma, celebrated target of synthetic chemistry. Here, we present stereoselective synthesis TTX proceeds 22 steps from glucose derivative. The central cyclohexane ring its α-tertiary amine moiety were established by the intramolecular 1,3-dipolar cycloaddition nitrile oxide, followed alkynyl addition to resultant isoxazoline. A ruthenium-catalyzed hydroxylactonization...
This article describes the first total synthesis of luminamicin using a strategy combining chemical degradation with synthesis. Chemical studies provided sense inherent reactivity natural product, and deconstruction molecule gave rise to key intermediate, which became target for The core structure southern part was constructed by 1,6-oxa-Michael reaction form an oxa-bridged ring, followed coupling functionalized organolithium species. Modified Shiina macrolactonization conditions forged...
Tetrodotoxin (TTX) is an indispensable probe in neuroscience, a biosynthetic and ecological enigma, one of the most celebrated targets synthetic chemistry. Here, we present stereoselective synthesis TTX that proceeds 22 steps starting from readily available glucose derivative. The central cyclohexane ring its α-tertiary amine moiety was established via intramolecular 1,3-dipolar cycloaddition nitrile oxide, followed by alkynyl addition to resultant isoxazoline. After some carefully chosen...
Tetrodotoxin (TTX) is an indispensable probe in neuroscience, a biosynthetic and ecological enigma, one of the most celebrated targets synthetic chemistry. Here, we present stereoselective synthesis TTX that proceeds 22 steps starting from readily available glucose derivative. The central cyclohexane ring its α-tertiary amine moiety was established via intramolecular 1,3-dipolar cycloaddition nitrile oxide, followed by alkynyl addition to resultant isoxazoline. After some carefully chosen...