A5030472020- Neonatal Respiratory Health Research
- Phytochemicals and Antioxidant Activities
- Cancer-related gene regulation
- Fermentation and Sensory Analysis
- Biocrusts and Microbial Ecology
- Psychology and Mental Health
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Algal biology and biofuel production
- Respiratory Support and Mechanisms
- Chronic Myeloid Leukemia Treatments
- Psidium guajava Extracts and Applications
- Wnt/β-catenin signaling in development and cancer
- Biochemical and biochemical processes
- Essential Oils and Antimicrobial Activity
- Literature, Culture, and Criticism
- Acute Myeloid Leukemia Research
- Acute Lymphoblastic Leukemia research
- Health, Nursing, Elderly Care
- Enzyme Catalysis and Immobilization
- Inflammatory Biomarkers in Disease Prognosis
- Bee Products Chemical Analysis
- Garlic and Onion Studies
- Prostate Cancer Treatment and Research
- melanin and skin pigmentation
- Youth, Drugs, and Violence
University of Trás-os-Montes and Alto Douro
2023-2025
University of Minho
2021-2024
Hospital Nossa Senhora da Conceição
2024
The historical use of plants as sources natural compounds has persisted over time. Increasing the intake bioactive substances shows significant potential for promoting overall well-being and health. This study delves into pigments, phenolic composition, profile, along with antioxidant properties, leaf extracts rich in bioactives from Azores region, contributing to sustainable primary food production. Analyses encompassed chlorophylls, carotenoids, total phenols, ortho-diphenols, flavonoids,...
A progressive fibrosing phenotype is critical in several lung diseases. It irreversible and associated with early patient mortality. Growing evidence has revealed pulmonary macrophages' role as modulators of the fibrotic processes. The proportion, phenotype, function alveolar (AM) interstitial macrophages (IM) at stages bleomycin-induced fibrosis have not been clearly described. In this way, our study aimed to characterize these macrophage populations investigate effect on fibroblast...
The Douro Demarcated Region's winery industry produces million tonnes of by-products annually, making their reuse essential to minimize environmental impact. Grape stems, rich in bioactive compounds and nutrients, have demonstrated potential health benefits. This study analysed four red grape stems from the region assess nutritional value benefit. Tryptophan, selenium, phenolic compounds, which regulate cognitive functions, protein enzyme synthesis, antioxidant processes, were analysed....
Prostate cancer (PCa) remains a significant global health concern, being major cause of morbidity and mortality worldwide. Furthermore, profound understanding the disease is needed. inflammation caused by external or genetic factors central player in prostate carcinogenesis. However, mechanisms underlying inflammation-driven PCa remain poorly understood. This review dissects diagnosis methods for pathophysiological disease, clarifying dynamic interplay between leukocytes promoting tumour...
Pulmonary fibrosis (PF) represents the pathologic end stage of several interstitial lung diseases (ILDs) associated with high morbidity and mortality rates. However, current treatments can only delay disease progression rather than provide a cure. The role inflammation in PF is well-established, but new insights into immune regulation are fundamental for developing more efficient therapies. c-MET signaling has been implicated migratory capacity effector functions cells. Nevertheless, this...
Acute respiratory distress syndrome (ARDS) is a life-threatening lung injury that currently lacks effective clinical treatments. Evidence highlights the potential role of glycogen synthase kinase-3 (GSK-3) inhibition in mitigating severe inflammation. The GSK-3α/β by CHIR99021 promoted fetal progenitor proliferation and maturation alveolar epithelial cells (AECs). precise impact repair regeneration during acute (ALI) remains unexplored. This study intends to elucidate influence on AEC...
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Acute respiratory distress syndrome (ARDS) is a life-threatening lung injury. After injury, severe inflammation, alveolar-capillary barrier permeability and alveolar epithelial cell (AEC) death lead to dysfunction. Glycogen synthase kinase-3 (GSK-3) an important molecule in proliferation differentiation. CHIR99021 (CHIR), GSK-3 inhibitor, modulates the maturation of progenitor cells 3D model. Thus, we aimed understand effects CHIR on AEC regeneration using LPS-induced acute injury (ALI)...