A5054370212- Angiogenesis and VEGF in Cancer
- Multiple Myeloma Research and Treatments
- Mast cells and histamine
- Cancer, Hypoxia, and Metabolism
- Cell Adhesion Molecules Research
- Protein Degradation and Inhibitors
- Proteoglycans and glycosaminoglycans research
- Congenital heart defects research
- Neuroblastoma Research and Treatments
- Platelet Disorders and Treatments
- Chemokine receptors and signaling
- Fibroblast Growth Factor Research
- Lymphatic System and Diseases
- Cancer Cells and Metastasis
- Immune Cell Function and Interaction
- Lymphoma Diagnosis and Treatment
- Ubiquitin and proteasome pathways
- Axon Guidance and Neuronal Signaling
- Immune cells in cancer
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Histone Deacetylase Inhibitors Research
- melanin and skin pigmentation
- Tissue Engineering and Regenerative Medicine
- Biomarkers in Disease Mechanisms
- T-cell and B-cell Immunology
University of Bari Aldo Moro
2016-2025
The Sense Innovation and Research Center
2021
Ospedale SS. Annunziata
2020
Weatherford College
2020
University of Brescia
1995-2020
Istituto Tumori Bari
2011-2018
Hudson Institute
2018
John Wiley & Sons (United States)
2018
Istituti di Ricovero e Cura a Carattere Scientifico
2007-2017
Block Center
2015
Tumour growth is angiogenesis-dependent. We found a high correlation between the extent of bone marrow angiogenesis, evaluated as microvessel area, and proliferating (S-phase) fraction plasma cells, labelling index (LI), in patients with multiple myeloma (MM) those monoclonal gammopathies undetermined significance (MGUS). Angiogenesis itself was significantly associated active opposed to non-active MM MGUS. The highest area accompanied rapidly progressive LI. When cut-off value 2% or greater...
Abstract Research within the anatomical sciences often relies on human cadaveric tissues. Without good will of these donors who allow us to use their bodies push forward our knowledge, most research would come a standstill. However, many papers omit an acknowledgement donor cadavers or, as no current standardized versions exist, language that is extremely varied. To remedy this problem, 20 editors‐in‐chiefs from 17 journals joined together put official recommendations can be used by authors...
Multiple myeloma (MM) pathogenesis and progression largely rely on the cells extracellular factors in bone marrow (BM) microenvironment. Compelling studies have identified tumour exosomes as key regulators maintenance education of BM microenvironment by targeting stromal cells, immune vascular cells. However, role MM modification remains unclear. Here, we explored functions angiogenesis immunosuppression vitro vivo. Murine carrying multiple angiogenesis-related proteins enhanced directly...
Human cadaveric donors are essential for research in the anatomical sciences. However, many papers sciences often omit a statement regarding ethical use of donor cadavers or, as no current standardized versions exist, language that is extremely varied. To rectify this issue, 22 editors-in-chief journals, representing 17 different countries, developed and simplified can be used by authors studies human tissues. The goal these editor recommendations to standardize writing approach which...
The analysis of cancer metabolome has shown that proliferating tumor cells require a large quantities different nutrients in order to support their high rate proliferation. In this study we analyzed the metabolic profile glycolysis and pentose phosphate pathway (PPP) human clear cell-renal cell carcinoma (ccRCC) evaluate role these pathways sustaining proliferation, maintenance NADPH levels, production reactive oxygen species (ROS). Metabolomic showed signature increased glucose uptake...
An altered metabolism is involved in the development of clear cell -renal carcinoma (ccRCC), and this tumor many genes play a fundamental role controlling metabolic activities.We delineated large-scale metabolomic profile human ccRCC, integrated it with transcriptomic data to connect variations cancer gene expression changes.Moreover, better analyze specific contribution alterations potentially associated tumorigenesis progression, we evaluated transcription primary renal cells.Untargeted...
Mucin1 (MUC1), a glycoprotein associated with an aggressive cancer phenotype and chemoresistance, is aberrantly overexpressed in subset of clear cell renal carcinoma (ccRCC). Recent studies suggest that MUC1 plays role modulating metabolism, but its regulating immunoflogosis the tumor microenvironment remains poorly understood. In previous study, we showed pentraxin-3 (PTX3) can affect ccRCC by activating classical pathway complement system (C1q) releasing proangiogenic factors (C3a, C5a)....
Abstract Bone marrow angiogenesis plays an important role in the pathogenesis and progression multiple myeloma. Recent studies have shown that proteasome inhibitor bortezomib (Velcade, formerly PS-341) can overcome conventional drug resistance vitro vivo; however, its antiangiogenic activity bone milieu has not yet been defined. In present study, we examined effects of on angiogenic phenotype myeloma patient–derived endothelial cells (MMEC). At clinically achievable concentrations, inhibited...