A5101964686- Respiratory Support and Mechanisms
- CAR-T cell therapy research
- Congenital Heart Disease Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Animal Virus Infections Studies
- Bacteriophages and microbial interactions
- Congenital Diaphragmatic Hernia Studies
- Viral gastroenteritis research and epidemiology
- Cardiac Arrest and Resuscitation
- Hepatitis C virus research
- Berry genetics and cultivation research
- Tracheal and airway disorders
- HIV/AIDS drug development and treatment
- Pulmonary Hypertension Research and Treatments
- Cancer Immunotherapy and Biomarkers
- Cancer Genomics and Diagnostics
- Cardiac Valve Diseases and Treatments
- Monoclonal and Polyclonal Antibodies Research
- Cardiac and Coronary Surgery Techniques
- Hepatitis B Virus Studies
- Neonatal Respiratory Health Research
- American Political and Social Dynamics
- Botanical Research and Chemistry
- Cardiovascular Issues in Pregnancy
University of Oxford
2018-2019
Miami Children's Hospital
1999-2008
University of Miami
1996
Chang Gung Children's Hospital
1996
Abstract Introduction: T cell engagers (TCEs) are a promising class of targeted therapies with recent clinical successes in solid tumors. A unique advantage HLA-presented targets is that they can be derived from any part the human genome providing an opportunity to build next generation TCEs against novel targets. We here present our discovery and development half-life extended TCE tumor-target towards candidate selection. Our proprietary drug format based on solubilized TCR, engineered as...
Abstract Introduction: T cell engagers (TCEs) are a class of targeted therapies with demonstrated clinical potential in solid tumors. A main challenge currently facing TCEs is the availability clean cancer targets wide therapeutic window. Intracellular presented to cells by HLA complexes strongly linked disease mechanisms and therefore very attractive, but drugging HLA-presented has been challenged our ability map specificity repertoires. We here present T-Cα platform, which represents...
We studied the effect of leaks around endotracheal tube (ETT) on measurement pulmonary mechanics during mechanical ventilation. also evaluated influence different ventilator settings magnitude leak. An adjustable leak was created at end ETT in a lung model with constant compliance. Flow, tidal volume, and pressure changes were measured above below Compliance (Ci) resistance (Ri) inspiration determined by linear regression analysis (LRA) using equation motion Mead Wittenberger method (MWM)....
We conducted a study with the objective of comparing performance two different systems for patient-triggered ventilation in neonates (impedance versus flow/volume-triggered) by measuring response time, autotrigger and trigger failure rates, ventilation, gas exchange. The ventilator were applied random order 10 preterm (median gestational age: 30.5 wk; range: 27 to 34 body weight: 1,266 g; 840 2,240 g) using identical settings. median (range) time was 169 (98 305) ms impedance system 115 (79...
Abstract The hepatitis C virus (HCV) viroporin p7 oligomerizes to form ion channels, which are required for the assembly and secretion of infectious viruses. 63-amino acid monomer has two putative transmembrane domains connected by a cytosolic loop, both N- C- termini exposed endoplasmic reticulum (ER) lumen. NMR studies have indicated differences between structures distantly related HCV genotypes. A critical question is whether these arise from high sequence variation different isolates if...
<h3>Background</h3> T cell engagers (TCEs) are a promising class of targeted therapies and recent clinical successes have shown the strong potential TCEs to drive robust response rates increase infiltration in solid tumours.<sup>1</sup> Intracellular targets presented by HLA provide an opportunity build next generation TCEs. Among these intracellular targets, PRAME is highly expressed target HLA-A*0201 or HLA-A*2402 across multiple cancers. We here present our discovery development half-life...
<h3>Background</h3> T cell engagers (TCEs) are a highly interesting class of targeted therapies which have enjoyed recent clinical success, showing the potential to drive robust response rates and increase infiltration in solid tumours. A major challenge for development TCEs is that potency this drug warrants cleaner targets with wider therapeutic windows than, example, ADCs. Currently, field severely limited by availability clean cancer very few exceptions. Intracellular presented cells HLA...
s Translations: Abstracts from the American Academy of Pediatrics: Oral Abstract Presentations