A5014686511- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Immune Cell Function and Interaction
- Cytokine Signaling Pathways and Interactions
- Radiomics and Machine Learning in Medical Imaging
- T-cell and B-cell Immunology
- Renal cell carcinoma treatment
- Melanoma and MAPK Pathways
- Cutaneous Melanoma Detection and Management
- Ferroptosis and cancer prognosis
- Explainable Artificial Intelligence (XAI)
- PI3K/AKT/mTOR signaling in cancer
- AI in cancer detection
- Cell Image Analysis Techniques
- Hematopoietic Stem Cell Transplantation
- HER2/EGFR in Cancer Research
- Renal and related cancers
- CAR-T cell therapy research
- Immune Response and Inflammation
- Cutaneous lymphoproliferative disorders research
- interferon and immune responses
- Cytomegalovirus and herpesvirus research
- Cancer, Hypoxia, and Metabolism
- Nonmelanoma Skin Cancer Studies
- Eosinophilic Disorders and Syndromes
Emory University
2016-2025
Veterans Health Administration
2011-2025
University of Pittsburgh
2019-2022
Atlanta VA Health Care System
2020-2022
Atlanta VA Medical Center
2014-2021
Winship Cancer Institute
2011-2019
Case Western Reserve University
2019
Piedmont Cancer Institute
2013-2019
Atlanta Medical Center
2017
United States Department of Veterans Affairs
2009-2017
Anticancer therapeutic effects can be improved by directing immune checkpoint blockade antibodies to tumor-draining lymph nodes.
To expand our understanding of the role Jak2 in cellular signaling, we used yeast two-hybrid system to identify Jak2-interacting proteins. One clones identified represents a human homologue <i>Schizosaccaromyces pombe S</i>hk1 kinase-binding protein 1, Skb1, and encoded by the<i>Saccharomyces cerevisiae HSL7</i> (histone synthetic lethal 7) gene. Since no functional motifs or biochemical activities for this its homologues had been reported, sought determine function protein. We demonstrate...
Population-based data on melanoma survival are important for understanding the impact of demographic and clinical factors prognosis.We describe by age, sex, race/ethnicity, stage, depth, histology, site.Using Surveillance, Epidemiology, End Results data, we calculated unadjusted cause-specific up to 10 years from diagnosis 68,495 first primary cases diagnosed 1992 2005. Cox multivariate analysis was performed 5-year survival. Data 2001 were divided into 3 time periods compare stage...
Diverse immune-related effects occur with the use of epidermal growth factor receptor inhibitors (EGFRI). In addition to cutaneous inflammation induced by EGFRIs, these agents have been associated exacerbation autoimmune skin disease and contact hypersensitivity, antiviral effects, fatal alveolar damage in setting lung transplantation. Because EGFR ligands can modulate MHC class I (MHCI) II (MHCII) molecule expression, we hypothesized that some EGFRIs are due direct on expression MHCI and/or...
To optimally integrate targeted kinase inhibitors and immunotherapies in the treatment of melanoma, it will be critical to understand how BRAFV600E mutational status inhibition influence expression genes that govern antitumor immune responses. Because major histocompatibility complex (MHC) molecules are for interactions between tumor cells lymphocytes, we investigated impact BRAFV600E-selective on MHC molecules. We found A375 melanoma with vemurafenib enhances induction Class I II by...
Abstract The etiology of ulcerative colitis is poorly understood and likely to involve perturbation the complex interactions between mucosal immune system commensal bacteria gut, with cytokines acting as important cross-regulators. Here we use IFN receptor-deficient mice in a dextran sulfate sodium (DSS) model acute intestinal injury study contributions type I III interferons (IFN) initiation, progression resolution colitis. We find that lacking both types receptors exhibit enhanced barrier...
Interferon γ (IFN-γ) signals through a multimeric receptor complex consisting of two different chains: the IFN-γ binding subunit (IFN-γR, IFN-γR1), and transmembrane accessory factor (AF-1, IFN-γR2) necessary for signal transduction. Using cell lines expressing cloned components complex, we examined function in transduction upon treatment. A specific IFN-γR2:IFN-γ cross-linked was observed cells both IFN-γR1 IFN-γR2 indicating that (AF-1) interacts with is closely associated IFN-γR1. We show...
Abstract Molecular events activating the PI3K pathway are frequently detected in human tumors and activation of signaling alters numerous cellular processes including tumor cell proliferation, survival, motility. More recent studies have highlighted impact on response to interferons other immunologic relevant antitumor immunity. Given ability IFNγ regulate antigen processing presentation pivotal role MHC class I (MHCI) II (MHCII) expression T-cell–mediated immunity, we sought determine MHCI...
Each cytokine which utilizes the Jak-Stat signal transduction pathway activates a distinct combination of members Jak and Stat families. Thus, either Jaks, Stats, or both could contribute to specificity ligand action. With use chimeric receptors involving interferon gamma receptor (IFN-gammaR) complex as model system, we demonstrate that Jak2 activation is not an absolute requirement for IFN-gamma signaling. Other family can functionally substitute Jak2. through other than measured by...
Abstract Graft-versus-host disease (GVHD) is a major cause of morbidity and mortality in patients treated with allogeneic hematopoietic stem cell transplantation (HSCT). Posttransplant immunosuppressive drugs incompletely control GVHD increase susceptibility to opportunistic infections. In this study, we used flagellin, TLR5 agonist protein (∼50 kDa) extracted from bacterial flagella, as novel experimental treatment strategy reduce both acute chronic HSCT recipients. On the basis...
ABSTRACT The Ebola virus (EBOV) surface glycoprotein (GP 1,2 ) mediates host cell attachment and fusion is the primary target for neutralizing antibodies. Expression of GP at high levels disrupts normal physiology, EBOV uses an RNA-editing mechanism to regulate expression gene. In this study, we demonstrate that impair production release virus-like particles (VLPs) as well infectivity -pseudotyped viruses. We further show effect mediated through two mechanisms. First, reduce synthesis other...
Propranolol is a widely used beta blocker that consists of racemic mixture R and S stereoisomers. Only the stereoisomer has significant activity against beta-adrenergic receptor. A fortuitous clinical observation was made in an infant who received propranolol for cardiac disease, regression hemangioma infancy noted. This led to widespread use treatment large life-threatening hemangiomas infancy. Infants receiving require monitoring ensure they do not suffer from side effects related...
Abstract Background Epidermal growth factor receptor inhibitors (EGFRIs) are used to treat certain cancers but frequently cause cutaneous inflammation that can hinder treatment. This is due in part the effects of EGFRIs on pro-inflammatory signaling by interferon-γ (IFN-γ). However, impact EGFR ligands (i.e. EGF) interferon unclear. The purpose this study was investigate EGF IFN-γ transcriptional responses a genome-wide scale keratinocytes. Methods RNA-seq performed human keratinocyte...
To understand potential mechanisms explaining interindividual variability observed in human sweat sodium concentration ([Na(+)]), we investigated the relationship among [Na(+)] of thermoregulatory sweat, plasma membrane expression Na(+) and Cl(-) transport proteins biopsied eccrine ducts, basal levels vasopressin (AVP) aldosterone. Lower ductal luminal channel cystic fibrosis transmembrane conductance regulator (CFTR) was immunofluorescent staining glands from healthy young adults identified...