A5019335074- Viral gastroenteritis research and epidemiology
- Animal Virus Infections Studies
- Hepatitis Viruses Studies and Epidemiology
- Virus-based gene therapy research
- Viral Infections and Immunology Research
- Veterinary medicine and infectious diseases
- CAR-T cell therapy research
- Respiratory viral infections research
- Viral-associated cancers and disorders
- Vector-Borne Animal Diseases
- Parvovirus B19 Infection Studies
- Plant Reproductive Biology
- Nanowire Synthesis and Applications
- Phytase and its Applications
- Food Industry and Aquatic Biology
- Immunotherapy and Immune Responses
- Liver Disease and Transplantation
- Viral Infectious Diseases and Gene Expression in Insects
- Animal Genetics and Reproduction
- Agriculture, Plant Science, Crop Management
- Axon Guidance and Neuronal Signaling
- Herpesvirus Infections and Treatments
- Animal Disease Management and Epidemiology
- Adipokines, Inflammation, and Metabolic Diseases
- Hepatitis C virus research
Istituto Superiore di Sanità
2010-2024
Università Cattolica del Sacro Cuore
2020-2024
University of Padua
2020-2021
Agostino Gemelli University Polyclinic
2020
Istituti di Ricovero e Cura a Carattere Scientifico
2020
Sapienza University of Rome
2015
Hepatitis E is an acute human disease caused by the hepatitis virus (HEV). In addition to humans, HEV has been detected in several animal species and recognized as a zoonotic pathogen. Pigs, wild boar deer can be reservoir. this study, we evaluated prevalence free-living red (Cervus elaphus) population central Italy detecting virus-specific antibodies RNA sera. A total of 35 251 sera were positive for anti-HEV IgG. was 10 91 examined. Two genomic fragments targeted diagnostic PCRs capsid...
The hepatitis E virus (HEV) has been detected in both humans and animals, particularly pigs, worldwide. Several evidences, including human infection following consumption of raw contaminated meat, suggest a zoonotic transmission HEV. In Italy, large circulation genotype 3 HEV reported swine, recent studies have confirmed the involvement this autochthonous cases. study 111 sera collected from healthy pigs two Italian regions were tested for anti-HEV IgG antibodies. For specific antibody...
Virus-like particles (VLPs) from an Italian GII.4 norovirus strain were used to investigate activation and maturation of circulating antigen presenting cells (APCs) human origin.Peripheral blood mononuclear (PBMCs) isolated five healthy subjects pulsed ex vivo with VLPs, stained a set monoclonal antibodies (MAbs) for phenotypic analysis by flow cytometry. Cytokine release in cell supernatants was investigated ELISA.Norovirus VLPs induced APCs derived the donors, as well production IL-6,...
Viruses belonging to the genus Norovirus (NoV) of family Caliciviridae are major cause acute viral gastroenteritis worldwide. NoVs classified into 10 genogroups (GI-GX), and those genogroup GV able infect several species rodents. To evaluate circulation MNV among mice housed in an Italian facility, sampling was performed over two separate periods, 2011, 3 years later 2014. During samplings, 75 fecal samples were collected from healthy animal facility subjected RT-PCR for detection. After...
Despite the introduction of directly acting antivirals (DAAs), for treatment hepatitis C virus (HCV) infection, their cost, patient compliance, and viral resistance are still important issues to be considered. Here, we describe generation a novel JFH1-based HCV subgenomic replicon double reporter cell line suitable testing different antiviral drugs therapeutic interventions. This cells allowed rapid accurate quantification growth/viability RNA replication, thus discriminating specific from...
Abstract Aloe‐emodin (1,8‐dihydroxy‐3‐[hydroxymethyl]‐anthraquinone), AE, is one of the active constituents a number plant species used in traditional medicine. We have previously identified, for first time, AE as new antitumor agent and shown that its selective vitro vivo killing neuroblastoma cells was promoted by cell‐specific drug uptake process. However, molecular mechanism underlying cell entry has remained elusive yet. In this report, we show enters tumor via two five somatostatin...