A5049974608- Orthodontics and Dentofacial Orthopedics
- Temporomandibular Joint Disorders
- Facial Trauma and Fracture Management
- Oral and Maxillofacial Pathology
- Craniofacial Disorders and Treatments
- RNA modifications and cancer
- Peptidase Inhibition and Analysis
- Facial Nerve Paralysis Treatment and Research
- Head and Neck Cancer Studies
- Dental Radiography and Imaging
- Cancer-related gene regulation
- Cleft Lip and Palate Research
- Facial Rejuvenation and Surgery Techniques
- Dental Implant Techniques and Outcomes
- Cancer-related molecular mechanisms research
- Head and Neck Surgical Oncology
- Cancer Diagnosis and Treatment
- Proteoglycans and glycosaminoglycans research
- Oral health in cancer treatment
- Reconstructive Surgery and Microvascular Techniques
- Bone Tissue Engineering Materials
- Nasal Surgery and Airway Studies
- Protease and Inhibitor Mechanisms
- Sinusitis and nasal conditions
- Laser Applications in Dentistry and Medicine
University of Yamanashi
2016-2025
Weatherford College
2023
National Confidential Enquiry into Patient Outcome and Death
2023
RELX Group (United States)
2021
Ann Arbor Center for Independent Living
2021
Greenville College
2021
University of Yamanashi Hospital
2021
Otsu Municipal Hospital
2020
Smith College
2017
Syracuse University
2017
Abstract The targeting of antioxidant systems that allow stem-like cancer cells to avoid the adverse consequences oxidative stress might be expected improve efficacy treatment. Here, we show head and neck squamous cell carcinoma (HNSCC) express variant isoforms CD44 (CD44v) rely on activity cystine transporter subunit xCT for control their redox status. inhibition selectively induces apoptosis in CD44v-expressing tumor without affecting CD44v-negative differentiated same tumor. In contrast...
Inhibition of epidermal growth factor receptor (EGFR) signaling has emerged as a novel therapeutic strategy for the treatment oral squamous cell carcinoma (OSCC). The EGFR-directed inhibitor cetuximab is currently only approved targeted therapy OSCC. EGFR status may affect patient response to treatment. In present study, via analysis immunomarker EGFR, it was revealed that 58.3% total cases investigated stained positively expression, and furthermore, invasiveness inversely correlated with...
Abstract ETS homologous factor (EHF) belongs to the epithelium-specific subfamily of E26 transformation-specific (ETS) transcription family. Currently, little is known about EHF’s function in cancer. We previously reported that ETS1 induces expression ZEB family proteins ZEB1/δEF1 and ZEB2/SIP1, which are key regulators epithelial–mesenchymal transition (EMT), by activating ZEB1 promoters. have found EHF gene produces two transcript variants, namely a long form variant includes exon 1...
Objective: This study evaluated the degree of paresthesia and recovery lower lip chin in patients who underwent sagittal split ramus osteotomy (SSRO) by measuring preoperative postoperative trigeminal somatosensory evoked potential (TSEP). Study Design: Thirty-seven with skeletal class II III malocclusion SSRO were included. TSEP was measured at 7 points: preoperatively 1 week, 1, 3, 6, 12, 18 months postoperatively. The Semmes-Weinstein monofilament test (SW test) also performed...
J Oral Pathol Med (2011) 40: 693–698 Background: Abnormalities in cell-cycle-controlling genes are important the malignant transformation and proliferation of tumors. Among these genes, tumor suppressor gene p53 is most notable, its mutations provide an indicator progression prognosis. Proliferating cell nuclear antigen (PCNA) a highly conserved protein that expressed during replication DNA repair. This study examined expression PCNA at invasive front oral squamous carcinomas (OSCC) by...
Background Vascular endothelial growth factor ( VEGF ) family members play a major role in angiogenesis and vascularization. ‐A promotes tumor by stimulating the of vascular cells. In addition, ‐C has been identified as potent inducer lymphangiogenesis lymph node metastasis. Previous studies have investigated association between clinicopathological factors expression ‐ C oral squamous cell carcinoma cancer OSCC ), but results are contradictory. this study, we relationship A prognosis....
The correlation between diabetic retinopathy and blood pressure was analyzed in 742 type II patients. Systolic pulse pressures were significantly higher the patients with than those without (mean systolic 142 vs. 139 mmHg, P < .01; mean 60.5 56.4 .001). There no difference diastolic these two groups. components of (including microaneurysms, hemorrhages, exudates) also analyzed. Even when patient microaneurysms or dot blot hard soft exudates separately evaluated, one changes them. To...
Background: Apoptosis is a genetically regulated cell death involved in the deletion of cells normal or malignant tissues. Proteins Bcl‐2 family play key role control apoptosis and carry out both pro‐apoptotic anti‐apoptotic functions. The present study evaluated prognostic value Bax expression at invasive front oral squamous carcinoma (OSCC), taking clinicopathological findings into account. Methods: Fifty‐six specimens OSCC were randomly selected, was by immunohistochemistry...
Objective: Maspin, a 42‐kDa protein, belongs to the serpin family of protease inhibitors and is known have tumor‐suppressor function. In this study, we investigated interrelationship between clinicopathologic findings maspin expression in oral squamous cell carcinoma (OSCC). Methods: Using immunohistochemical techniques examine levels OSCC, OSCC was detected 46 (64.8%) 71 cases. We also compared clonicopathologic features cases with levels. Moreover, examined eight lines derived from using...
The epithelial–mesenchymal transition (EMT) is a crucial morphological event that occurs during epithelial tumor progression. Snail and ZEB1/2 (ZEB1 ZEB2), known as EMT transcription factors, are key regulators of this transition. positively correlated with phenotypes the aggressiveness cancers. On contrary, also cancers, but not expression marker proteins. induced by transforming growth factor‐β (TGF‐β), well‐known inducer EMT, in various cancer cells. Interestingly, induction TGF‐β...