A5102747434- EEG and Brain-Computer Interfaces
- Functional Brain Connectivity Studies
- Epilepsy research and treatment
- Neural dynamics and brain function
- Traumatic Brain Injury and Neurovascular Disturbances
- Vestibular and auditory disorders
- Heart Rate Variability and Autonomic Control
- Neurobiology of Language and Bilingualism
- HIV/AIDS drug development and treatment
- Cardiac Arrest and Resuscitation
- Autoimmune Neurological Disorders and Treatments
- HIV Research and Treatment
- Yersinia bacterium, plague, ectoparasites research
- HIV/AIDS Research and Interventions
- Vasculitis and related conditions
- Neurological Complications and Syndromes
- Skin Diseases and Diabetes
- Muscle activation and electromyography studies
- Peripheral Neuropathies and Disorders
- Trigeminal Neuralgia and Treatments
- Natural Language Processing Techniques
- Systemic Sclerosis and Related Diseases
- Blood Coagulation and Thrombosis Mechanisms
- Infectious Encephalopathies and Encephalitis
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
Kobe University
2020-2025
Kyoto University
2008-2025
Kobe City Medical Center General Hospital
2014-2022
Université des Sciences, des Techniques et des Technologies de Bamako
2021
Neurology, Inc
2018
Kyushu University
2008
Sapporo Medical University
1960
Trigeminal sensory nuclei are the first processing stage in vibrissal system of rodents. They feature separate populations thalamic projecting cells and a rich network intersubnuclear connections, so that what is conveyed to cortex by each ascending pathways information depends on local transactions occur brainstem. In present study, we examined nature these connections combining electrolytic lesions with electrophysiological recordings, retrograde labeling situ hybridization, anterograde...
The medial parietal cortices are components of the default mode network (DMN), which active in resting state. include precuneus and dorsal posterior cingulate cortex (dPCC). Few studies have mentioned differences connectivity cortices, these not yet been precisely elucidated. Electrophysiological is essential for understanding cortical function or functional differences. Since little known about electrophysiological connections from humans, we evaluated distinct patterns by constructing a...
Abstract We revisited the anatomo-functional characteristics of basal temporal language area (BTLA), first described by Lüders et al. (1986), using electrical cortical stimulation (ECS) in context Japanese and semantic networks. recruited 11 patients with focal epilepsy who underwent chronic subdural electrode implantation ECS mapping multiple tasks for presurgical evaluation. A semiquantitative function density map delineated BTLA (66 electrodes, mean 3.8 cm from tip). The ECS-induced...
Bickerstaff's brainstem encephalitis (BBE) is a rare post-infectious inflammatory disease, which causes impaired consciousness by the dysfunction of ascending reticular activating system (ARAS). We aimed to clarify EEG changes possibly caused ARAS in BBE.We retrospectively investigated 15 EEGs from 5 patients with definite BBE (i.e., positivity for serum IgG anti-GQ1b antibodies was mandatory diagnosis) admitted our hospital January 2014 through December 2019, particularly focusing on...
Cerebral air embolism is a rare cause of cerebral infarction. In embolism, T2 star-weighted imaging shows numerous spotty hypointense signals. Previous reports have suggested that these signals represent in the brain and are gradually diminished absorbed. We experienced two cases one them, we conducted an autopsy. Case 1 was 76-year-old Japanese man with lung cancer emphysema. A spasmodic cough induced massive cardiac embolisms patient died because herniation. magnetic resonance showed...
症例は57歳男性である．HIV（human immunodeficiency virus）に対するcART（combination antiretroviral therapy）中に認知機能低下が出現し，頭部MRIで両側大脳白質や脳幹部に病変をみとめた．髄液中HIV-RNAが血中HIV-RNAよりも高値を示し，薬剤耐性検査で抗HIV薬への耐性が判明．薬剤耐性と中枢神経移行性を考慮して抗HIV薬を変更し，認知機能の改善と髄液中HIV-RNAの陰性化がえられた．抗HIV薬の選択にあたっては，中枢神経移行性を考慮することが重要である．
感覚発作から焦点意識減損強直発作,ついで焦点起始両側強直間代発作に進展した若年男性の2症例を経験した.発作型は片側上肢の異常感覚から上下肢が伸びる強直姿勢をとり,焦点起始両側強直間代発作に至った.異常感覚や強直姿勢は帯状回皮質への皮質電気刺激で報告があり,感覚発作や焦点意識減損強直発作を認める場合には帯状回由来の発作を疑う必要がある.2例とも頭部MRIで帯状回に異常信号を認め,血液中の抗ミエリンオリゴデンドロサイト糖蛋白(myelin oligodendrocyte glycoprotein,以下MOGと略記)抗体陽性が判明し,抗MOG抗体陽性大脳皮質脳炎と診断した.ステロイド治療が有効だった経過から抗MOG抗体関連疾患による帯状回病変が発作の焦点となったと考えた.
We encountered a 64-year-old Japanese woman who developed subarachnoid hemorrhaging (SAH) with multiple cerebral artery stenoses during remission induction therapy for eosinophilic granulomatosis and polyangiitis (EGPA). The treatment involved intensified steroid pulse continued intravenous cyclophosphamide therapy, which led to beneficial effects. Given the rarity of EGPA-associated SAH, it is crucial differentiate them from other diseases. mortality rate EGPA complicated by intracranial...
後脊髄動脈領域の梗塞は脊髄梗塞の中でも稀であり,延髄下部から上位頚髄の背側領域の障害を来すことがある.延髄下部では三叉神経脊髄路核と楔状束は解剖学的に近接しているが,今回後脊髄動脈領域の梗塞により両部位が障害され,特異的な感覚障害を呈した症例を経験した.症例は74歳,男性.突然の上肢優位の左上下肢の深部感覚障害とonion-skin patternの左顔面感覚障害を呈した.MRIで延髄下部から上位頚髄の梗塞を認め,MRAとCT-angiographyの所見から左椎骨動脈解離が疑われた.体性感覚誘発電位で左後索障害を示す所見を認めた.アスピリンの内服とリハビリテーションを継続し,発症3カ月後には左上肢の深部感覚障害と左顔面の感覚障害の改善を認めた.顔面の異常感覚と同側の上肢の深部感覚障害は,延髄下部から上位頚髄の病変で起こり,通常の頭部MRI撮影で見逃しやすい部位であり,注意が必要である.
Triplex-forming oligonucleotides (TFOs) bind within the major groove of duplex DNA in a sequence-specific manner, and have attracted much interest as genomic tools. However, triplex is formed by interaction between TFOs homopurine/homopyrimidine sequences target DNA, stable formation prevented one pyrimidine base homopurine strand. Previously, we developed nucleoside analogues (WNA: W-shaped analogues) that furnish an aromatic ring stacking part nucleobase recognition onto bicyclic skeleton....
Slow wave with frequency <0.5 Hz are recorded in various situations such as normal sleep, epileptic seizures. However, its clinical significance has not been fully clarified. Although infra-slow activity was recently defined between 0.01 and 0.1 Hz, we focus on the time constant of 2 seconds for practical usage. We short "infraslow" (SISA) less than 0.5 investigated occurrence SISA acute anoxic encephalopathy.This study evaluated findings electroencephalography consecutive 98 comatose...
Introduction: Acquired immunodeficiency syndrome (AIDS) linked to HIV infection is accompanied by auto-immune phenomena. Autoimmune diseases can develop in people living with HIV, most a context of good immunological control (vasculitis, anti-phospholipid syndrome). Since the advent antiretroviral therapy, an increasing number autoimmune connective tissue such as systemic lupus erythematosus, dermatomyositis, and syndromes Sj?gren scleroderma have been reported. Purpose: To describe this...