A5059613225- Urological Disorders and Treatments
- Bladder and Urothelial Cancer Treatments
- Carbon and Quantum Dots Applications
- Epigenetics and DNA Methylation
- Graphene and Nanomaterials Applications
- Nanoplatforms for cancer theranostics
- RNA Interference and Gene Delivery
- Graphene research and applications
- 2D Materials and Applications
Harvard University
2020-2022
Brigham and Women's Hospital
2020-2022
Abstract Clay-based nanomaterials, especially 2:1 aluminosilicates such as vermiculite, biotite, and illite, have demonstrated great potential in various fields. However, their characteristic sandwiched structures the lack of effective methods to exfoliate two-dimensional (2D) functional core layers (FCLs) greatly limit future applications. Herein, we present a universal wet-chemical exfoliation method based on alkali etching that can intelligently “capture” ultrathin biocompatible FCLs (MgO...
Lysine-specific demethylase 6A (KDM6A), also named UTX, is frequently mutated in bladder cancer (BCa). Although known as a tumor suppressor, KDM6A's therapeutic potential the metastasis of BCa remains elusive. It difficult to fulfill effective up-regulation KDM6A levels tissues situ verify its treating metastasis. Here, we report mucoadhesive messenger RNA (mRNA) nanoparticle (NP) strategy for intravesical delivery KDM6A-mRNA mice bearing orthotopic Kdm6a-null and show evidence inhibiting...