A5108095991- Advanced Drug Delivery Systems
- biodegradable polymer synthesis and properties
- Proteins in Food Systems
- Advanced Polymer Synthesis and Characterization
- Protein purification and stability
- Supramolecular Self-Assembly in Materials
- Analytical Methods in Pharmaceuticals
- Nanoparticle-Based Drug Delivery
- Mineral Processing and Grinding
- Polymer Synthesis and Characterization
- Enzyme Production and Characterization
- Carbon dioxide utilization in catalysis
- Drug Solubulity and Delivery Systems
- Electrospun Nanofibers in Biomedical Applications
- Metal Extraction and Bioleaching
- Antimicrobial agents and applications
- Analytical Chemistry and Chromatography
- Osteoarthritis Treatment and Mechanisms
- Hydrogels: synthesis, properties, applications
- Injection Molding Process and Properties
- Polymer Foaming and Composites
- Inflammatory mediators and NSAID effects
Al-Baath University
2020-2024
Micro et Nanomédecines translationnelles
2012-2015
Inserm
2012-2015
Université d'Angers
2012-2015
Zimmer Biomet (France)
2012-2014
Nanomed (Brazil)
2014
Université Nantes Angers Le Mans
2012
Nanoparticles of biocompatible and biodegradable polymers such as poly(lactic-co-glycolic acid) (PLGA) are widely used drug delivery systems for the administration biomolecules like proteins.The purpose this work is to validate a novel formulation method by phase separation phenomenon using non-toxic solvent glycofurol (GF) in order encapsulate proteins into PLGA nanoparticles.Nanoprecipitates model protein (lysozyme) therapeutic (TGF-β1) were formed ensure their stability upon subsequent...
الدوكسيسكلين هايكلات هو مضاد حيوي واسع الطيف ينتمي لعائلة التتراسيكلينات، يستخدم بشكل في معالجة العديد من الأمراض الالتهابيًة، ويعتبر الخط العلاجي الأوًل تدبير الحالات المتوسطة إلى الشديدة حب الشًباب. تم هذا البحث صياغة أربع صيغ نصف صلبة للدوكسيسيكلين (F2,F1 كصيغ هلاميًة، F3,F4 مرهميًة)، ثم عُرّضت الصيغ السابقة شروط ثبات مسرًعة حاضنات الثبات لمدة ثلاثة أشهر. تقييم المحضرة باستخدام طرق ميكروبيولوجيًة وتحليلية وذلك خلال شهر وثلاثة استخدمت طريقة الانتشار على الآغار لتقييم الفعاليًة المضادة...
The aim of this work was to develop a novel formulation method, termed modified-PGSS (modified-Particle from Gas Saturated Solution), for the encapsulation protein into polymeric microparticles in CO2 medium. In study, isosorbide dimethyl ether (DMI), non-toxic water-miscible solvent, used and lysozyme chosen as model PLGA microparticles. First, mechanism particle formation has been extensively studied discussed detail. Phase behavior investigated by measuring solubility DMI volumetric...
Amoxicillin trihydrate-loaded hydrogel beads were prepared and characterized as a controlled drug delivery system to improve patient compliance. An ionotropic gelation process was used prepare the using calcium chloride (CaCl2) crosslinking agent. The effects of CaCl2, sodium alginate, poloxamer 407 (PL) concentration, preparation temperature investigated. Spherical obtained with high encapsulation efficiency (85.74±1.09) %. FTIR analyses confirmed compatibility amoxicillin excipients. In...
In this study, a rapid, simple, economical and accurate spectrophotometric process was developed for the determination of sodium diclofenac in modified release tablets using ethanol 96% as an available non-toxic solvent. Sodium standard solution scanned under UV (200-400 nm) 1 cm quartz cell to determine maximum absorption wavelength which 285 nm. This method validated accordance with requirements International Conference on Harmonization (ICH), where calibration curve showed linearity...