A5058529378- Genetics and Neurodevelopmental Disorders
- Metabolism and Genetic Disorders
- Neonatal Health and Biochemistry
- Fetal and Pediatric Neurological Disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- Neurogenetic and Muscular Disorders Research
- Epilepsy research and treatment
- Cytomegalovirus and herpesvirus research
- Herpesvirus Infections and Treatments
- Neonatal and fetal brain pathology
- Autism Spectrum Disorder Research
- Animal Virus Infections Studies
- RNA modifications and cancer
- Rabies epidemiology and control
- interferon and immune responses
- Pancreatic function and diabetes
- Legionella and Acanthamoeba research
- RNA and protein synthesis mechanisms
- Reproductive Physiology in Livestock
- Spinal Dysraphism and Malformations
- Plant and fungal interactions
- Long-Term Effects of COVID-19
- Microbial infections and disease research
- Neurological Complications and Syndromes
- Infectious Encephalopathies and Encephalitis
Medical University Plovdiv
2012-2023
Abstract Lenticulostriate vasculopathy (LSV) is a sonographic finding in infancy with obscure etiology and variable diagnostic prognostic significance. Ischemic infarct the territory of lenticulostriate vessels after mild head trauma rare pathology. There are no publications on LSV followed by ischemic infarct. We present case an 8‐month‐old boy who suffered developed brain preexisting LSV. It speculated that might be predisposing factor for infants. © 2012 Wiley Periodicals, Inc. J Clin Ultrasound,
The comorbidity of autistic spectrum disorder (ASD) and epilepsy has been widely discussed but many questions still remain unanswered. aim this study was to establish the occurrence among children with ASD define type epileptic seizures syndromes, age onset epilepsy, EEG abnormalities, used antiepileptic drugs therapeutic responses for behavior, as well find some correlations between gender, etiology intellectual disability (ID). A retrospective medical files 59 patients (aged 1⁻18 years)...
Investigation of 31 Roma patients with congenital lactic acidosis (CLA) from Bulgaria identified homozygosity for the R446* mutation in PDHX gene as most common cause disorder this ethnic group. It accounted around 60% study and over 25% all CLA cases referred to National Genetic Laboratory Bulgaria. The detection a homozygous patient Hungary carriers among population controls Romania Slovakia suggests wide spread European population. clinical phenotype twenty homozygotes was relatively...
Hearing loss is a common manifestation of the long-term complications in patients with shunt treated hydrocephalus along motor development disturbance, cognitive and visual impairment, epilepsy endocrine disorders. The aim present study was to investigate alterations hearing non-tumor etiology at least one year after implantation ventriculo-peritoneal shunt, as well their impact on quality life patients. included 70 (age range 1.25 years - 21.25 years) shunted placement system. were proved...
Hypomyelination with atrophy of the basal ganglia and cerebellum (H-ABC) is a neurodegenerative disease neurodevelopmental delay, motor, speech regression, pronounced extrapyramidal syndrome, sensory deficits due to TUBB4A mutation. In 2017, severe variant was described in 16 Roma infants mutation UFM1.The objective this study expand clinical manifestations H-ABC UFM1 suggest clues for diagnosis.Retrospective analysis all 9 cases c.-273_-271delTCA treated during 2013-2020 Neuropediatric Ward...
Abstract Data on cytomegalovirus infection (CMV) prevalence and course in hospitalized infants are rather scarce, obsolete considerably inconsistent. AIM: to determine the prevalence, rate of clinical manifestations, risk factors predictive capacity manifestations CMV during their first year life. PATIENTS AND METHODS: All 163 Pediatric Ward for Nonrespiratory Pathology a tertiary hospital were serologically screened 10 months. In up 6 months old that IgG (+) IgM (-) we followed...
Diagnosis of autism spectrum disorder (ASD) before the age three years is a challenge. Analyzing present practice may help reaching that goal. Aim: To investigate developmental abnormalities and diagnostic pathway ASD patients in pediatric practice. Methods: Retrospective cross-sectional study 192 children aged 13 months to 17 11 (average 4 9 months), investigated an outpatient hospital setting from January 2015 June 2018 by semi-structured history clinical examination, diagnosed with...
Hypoglycemia is not an independent diagnosis. It a pathophysiological syndrome whose cause needs to be identified. Identifying it just the first step making diagnosis as precisely possible and preventing brain damage. Timely treatment are factors of paramount importance for prognosis affected patients. The aim this study was present two our patients with hyperinsulinemic hypoglycemia because rarity condition propose diagnostic-therapeutic algorithm hypoglycemic in childhood. genetic...
Background. Dravet syndrome (DS) is the most severe form of Generalized Epilepsy with Febrile Seizures plus (GEFS+) a clear genetic component in 85% cases. It characterized by fever-provoked seizure onset around six months age and subsequent developmental deterioration later life. Methods. In current study, 60 patients seizures suspicion either GEFS+ (50 patients) or DS (10 were referred for SCN1A gene sequence analysis. Results. sequencing revealed clinically significant variants 11...
Abstract AIM: To study the development of children with selectively treated cytomegalovirus infection. PATIENTS AND METHODS: We studied prospectively a risk group 12 These were diagnosed by serological screening in first three months after birth and are defined as congenital perinatal infections. Thirteen infants no evidence previous or present infection at 4 - age used controls. Ganciclovir dose 10-15 mg/kg/day for least 2 weeks followed 5-7.5 administered intravenously more was given to...
<h3>Objectives</h3> Although congenital syphilis is a completely preventable disease, its incidence in Bulgaria has experienced an increase the recent 15 years. <h3>Methods</h3> A 25-day male newborn with wide spectrum of clinical features presented. <h3>Results</h3> The child was hospitalised quite bad condition fever, interstitial pneumonia, swollen and painful knee tarsal joints, reduced active movement left schoulder, erythemo-bullous rush palms soles (palmoplantar pemphigus). bone...
Acute hemiparesis is an emergency of various etiologies and possible fatal outcome.