Zane Perkins

ORCID: 0000-0003-4807-8803
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About
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Research Areas
  • Trauma and Emergency Care Studies
  • Trauma, Hemostasis, Coagulopathy, Resuscitation
  • Cardiac Arrest and Resuscitation
  • Cardiac, Anesthesia and Surgical Outcomes
  • Airway Management and Intubation Techniques
  • Trauma Management and Diagnosis
  • Abdominal Trauma and Injuries
  • Emergency and Acute Care Studies
  • Vascular Procedures and Complications
  • Pelvic and Acetabular Injuries
  • Machine Learning in Healthcare
  • Electronic Health Records Systems
  • Sepsis Diagnosis and Treatment
  • Traumatic Brain Injury and Neurovascular Disturbances
  • Bayesian Modeling and Causal Inference
  • Disaster Response and Management
  • Artificial Intelligence in Healthcare and Education
  • Autopsy Techniques and Outcomes
  • Bone fractures and treatments
  • Explainable Artificial Intelligence (XAI)
  • Reconstructive Surgery and Microvascular Techniques
  • Acute Kidney Injury Research
  • Respiratory Support and Mechanisms
  • Peripheral Artery Disease Management
  • Hemodynamic Monitoring and Therapy

Queen Mary University of London
2016-2025

London Ambulance Service NHS Trust
2012-2025

Barts Health NHS Trust
2008-2025

St Bartholomew's Hospital
2025

Royal London Hospital
2012-2024

National Health Service
2023-2024

ORCID
2024

Royal College of Surgeons of Edinburgh
2024

Alabama College of Osteopathic Medicine
2024

Transnational Press London
2013-2018

10.1016/j.ejvs.2012.05.013 article EN publisher-specific-oa European Journal of Vascular and Endovascular Surgery 2012-06-02

Abstract Introduction Rapid Sequence Induction of anaesthesia (RSI) is the recommended method to facilitate emergency tracheal intubation in trauma patients. In situations, a simple and standardised RSI protocol may improve safety effectiveness procedure. A crucial component developing selection induction agents. The aim this study compare traditional using etomidate suxamethonium with modified fentanyl, ketamine rocuronium. Methods We performed comparative cohort major patients undergoing...

10.1186/s13054-015-0872-2 article EN cc-by Critical Care 2015-03-19

Background Hemorrhage is the most common cause of potentially preventable death after injury. Early identification patients with major hemorrhage (MH) important as treatments are time-critical. However, diagnosis can be difficult, even for expert clinicians. This study aimed to determine how accurate clinicians at identifying MH in prehospital setting. A second aim was analyze factors associated missed and overdiagnosis MH, impact on mortality. Methods Retrospective evaluation consecutive...

10.1136/tsaco-2023-001214 article EN cc-by Trauma Surgery & Acute Care Open 2024-01-01

Traumatic cardiac arrest (TCA) presents a critical challenge in trauma care, often occurring rapidly after injury before effective interventions are available. To evaluate the association of prehospital resuscitative thoracotomy with survival outcomes for TCA. This retrospective cohort study examined all cases TCA London from January 1999 to December 2019. Data were analyzed July 2022 2023. Prehospital The primary outcome was hospital discharge. Secondary included admission and neurological...

10.1001/jamasurg.2024.7245 article EN cc-by JAMA Surgery 2025-02-26

Background Injured patients are at risk of developing acute kidney injury (AKI), which is associated with increased morbidity and mortality. The aim this study to describe the incidence, timing, severity AKI in a large trauma population, identify factors for AKI, report mortality outcomes. Methods A prospective observational injured adults, who met local criteria team activation, were admitted UK Major Trauma Centre. was defined by Kidney Disease Improving Global Outcomes (KDIGO) criteria....

10.1371/journal.pone.0211001 article EN cc-by PLoS ONE 2019-01-25

Abstract Background Timely and accurate identification of life- limb-threatening injuries (LLTIs) is a fundamental objective trauma care that directly informs triage treatment decisions. However, the diagnostic accuracy clinical examination to detect LLTIs largely unknown, due risk contamination from in-hospital diagnostics in existing studies. Our aim was assess initial for detecting (LLTIs). Secondary aims were identify factors associated with missed injury overdiagnosis, determine impact...

10.1186/s13049-023-01083-z article EN cc-by Scandinavian Journal of Trauma Resuscitation and Emergency Medicine 2023-04-07

10.1016/j.jbi.2013.10.012 article EN publisher-specific-oa Journal of Biomedical Informatics 2013-11-02

We describe the impact of a targeted performance improvement programme and associated interventions, on mortality rates, error rates process care for haemodynamically unstable patients with pelvic fractures. Clinical data 185 adult exsanguinating trauma presenting to United Kingdom Major Trauma Centre between January 2007 2011 were analysed univariate multivariate regression compared National data. In total 62 (34%) died from their injuries opportunities improved identified in one third...

10.1302/0301-620x.96b8.33383 article EN The Bone & Joint Journal 2014-08-01

Blood transfusion for bleeding trauma patients is a promising pre-hospital intervention with potential to improve outcomes. However, it not yet clear which may benefit from transfusions. The aim of this study was enhance our understanding how experienced clinicians make decisions regarding patient blood loss and the need transfusion, explore factors that influence clinical decision-making.Pre-hospital physicians, two air ambulance sites in south England, were interviewed between December...

10.1136/emermed-2023-213086 article EN cc-by Emergency Medicine Journal 2023-09-13

The acutely injured brain is sensitive to fluctuations in blood pressure. During tracheal intubation, airway stimulation provokes acute surges pressure that have the potential cause further harm patients with intracranial pathology. Although reduced consciousness thought suppress reflexes, its influence on these hemodynamic reflexes unknown.We aimed investigate relationship between head injury severity and response laryngoscopy intubation.This retrospective observational study included 97...

10.1097/ta.0b013e3182827305 article EN Journal of Trauma and Acute Care Surgery 2013-03-22
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