A5084818224- Colorectal Cancer Surgical Treatments
- Anorectal Disease Treatments and Outcomes
- Extracellular vesicles in disease
- Colorectal and Anal Carcinomas
- Ferroptosis and cancer prognosis
- Gastrointestinal Tumor Research and Treatment
- Circular RNAs in diseases
- Genetic factors in colorectal cancer
- Colorectal Cancer Screening and Detection
- Pelvic floor disorders treatments
- Cancer, Lipids, and Metabolism
- Gastric Cancer Management and Outcomes
- Cancer-related molecular mechanisms research
- Lipid metabolism and disorders
- Galectins and Cancer Biology
- MicroRNA in disease regulation
- Colorectal Cancer Treatments and Studies
- Invertebrate Immune Response Mechanisms
- Salivary Gland Tumors Diagnosis and Treatment
- Parasites and Host Interactions
- Traditional Chinese Medicine Studies
- Neuroendocrine Tumor Research Advances
- Cancer Cells and Metastasis
- RNA modifications and cancer
- Plant-based Medicinal Research
Peking Union Medical College Hospital
2021-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2021-2024
First Affiliated Hospital of Bengbu Medical College
2021
The First Affiliated Hospital, Sun Yat-sen University
2019
Sun Yat-sen University
2017-2019
Jishou University
2017
Colorectal cancer (CRC) is a common gastrointestinal malignancy, and recurrence metastasis contribute considerably to its high mortality. It well known that the epithelial-mesenchymal transition (EMT) accelerates rate of cell dissemination migration, thus promoting metastasis. Targeted therapy modality for treatment, it can play role in inhibiting progression. In this study, bioinformatics was used search genes associated with prognosis CRC. First, differential analysis performed on colon...
Colorectal cancer (CRC) is the second leading cause of cancer-induced death in world. Cancer-associated fibroblasts (CAFs) released exosomes that contributed to progression. This research was carried out study influence CRC-associated fibroblasts-derived on phenotype CRC cells and underlying mechanism. CAFs-derived (CAFs-exo) normal (NFs)-derived (NFs-exo) were recognized by transmission electronic microscopy, nanoparticle tracking analysis western blot analysis. Cell counting kit-8, flow...
Recent findings have shown that inflammation indices are associated with prognosis in various malignancies. However, the usefulness of including platelet-to-lymphocyte ratio, neutrophil-to-lymphocyte ratio and prognostic nutritional index for gastrointestinal stromal tumors (GISTs) remains controversial.We retrospectively reviewed 340 primary localized GIST patients who had received surgical resection between 2005 2015 to investigate effect on prognosis. 206 were selected by propensity score...
Transanal endoscopic microsurgery (TEM) has been accepted worldwide for the treatment of local rectal lesions. We aimed to assess efficacy and safety TEM in neuroendocrine tumors (RNET).A retrospective study patients who had undergone RNET at our institution between December 2006 June 2019 was performed. Demographic tumor characteristics, operative pathological details, complications, anal function questionnaires, follow-up data were included.A total 144 included. performed as primary...
Rectal cancer (RC) is one of the most common malignant tumors. Ferroptosis an iron-dependent form cell death, which plays important role in various cancers. However, correlation between ferroptosis-related genes (FRGs) and prognosis RC remains unclear.Gene expression data from The Cancer Genome Atlas Rectum adenocarcinoma (TCGA-READ) GSE87211 were downloaded. Clustering functional enrichment evaluated. A FRGs risk score was established based on univariate Cox analysis Least absolute...
Background: Described by Heald in 1982, total mesorectal excision (TME) is now routinely performed as the standard procedure for mid-low rectal cancer, with remarkable decrease local recurrence and improved oncology outcome. However, integrity of resected mesentery damage to autonomic nerves still remain challenging general surgeons, especially cohort neoadjuvant therapy patients. The concept modular resection (RMR), based on an integral understanding regional anatomy, was proposed a...
Abstract Chemoresistance is a primary contributor to distant metastasis in the context of neoadjuvant chemoradiotherapy (nCRT) rectal cancer, underlying mechanisms remain elusive. In this study, profiles plasma exosome miRNAs were compared two dimensions according treatment responses (poor/well-responders) and courses (pre/post-nCRT) by RNA-sequencing. The hsa-miR-483-5p was up-regulated well-responders post-nCRT. bioinformatic analysis revealed that target genes mainly enriched...
Abstract Background Doctors are at high risk of developing hemorrhoidal disease (HD), but it is unclear whether doctors aware this risk. The OASIS (dOctors AS patIentS) study was performed to examine the prevalence, awareness, diagnosis, and treatment HD among in big cities China. Methods An online survey consisting a structured questionnaire carried out grade-A tertiary hospitals 29 provinces across China from August October 2020. Results A total 1227 responses were collected. prevalence...
Chemoresistance is the primary contributor to distant metastasis in context of neoadjuvant chemoradiotherapy (nCRT) for rectal cancer. However, underlying mechanisms remain elusive.
Abstract Background: Doctors are at high risk of developing hemorrhoidal disease (HD), but it’s still not clear that how much doctors aware this problem. OASIS (dOctors AS patIentS) study was conducted to understand the prevalence, awareness, diagnosis and treatment HD among in big cities China. Methods: From August October 2020, an online survey through questionnaire from grade-A tertiary hospitals 29 provinces across Results: A total 1227 questionnaires were collected. The prevalence...
The Miao medical LIU's (LIU Kaiyun) infant tuina genre in western Hunan Province is one of the most famous genres China. Based on physiological and pathological characteristics infants, generation-inhibition theory five-elements medical's promotion-inhibition five-meridians, protocol "Tui Wu Jing" was flexibly adjusted; according to different constitution types, including lung-deficiency type, spleen-deficiency kidney-deficiency qi-deficiency yin-deficiency yang-deficiency phlegm-wet...
Abstract Background Doctors are at high risk of developing hemorrhoidal disease (HD), but it’s still not clear that how much doctors aware this problem. OASIS (dOctors AS patIentS) study was conducted to understand the prevalence, awareness, diagnosis and treatment HD among in big cities China. Methods From August October 2020, an online survey through questionnaire from grade-A tertiary hospitals 29 provinces across Results A total 1227 questionnaires were collected. The prevalence 56.8%,...
OBJECTIVE To assess the value of combination multiple proteins in predicting prognosis colorectal cancer (CRC) through bioinformatics analysis. The protein expression and clinical data were downloaded from TCPA database. Perl R used to screen prognostic-related proteins, Cox analysis, that served as independent prognostic factors CRC identified build prediction model. Survival analyses conducted for each included model risk score model, curves was drawn patients' survival status verify...
Abstract Background The choice of subsequent treatment for intermediate risk rectal tumors after Transanal endoscopic microsurgery (TEM) between adjuvant chemoradiotherapy and total mesorectal excision (TME) is controversial. present study aimed to compare survival functional outcome these two strategies. Methods This retrospective included early cancer patients TEM in our center 2010 2017. Patients were divided into TME groups. Intermediate was defined as pT1 with lymphovascular invasion,...