A pressure ulcer is the necrosis of skin and tissues due to prolonged pressure. Its prevention treatment are great importance not only for health but also patient’s quality life considered highest priority. In present study, a reliable analytical method developed quantitative determination panthenol, hesperidin, rutin, allantoin by HPLC UV detectors. The substances were formulated into pharmaceutical gel, with healing regenerative properties recommended first- second-degree bedsores. Their...

The undeniable value of sleep is commonly accepted and essential for all aspects human existence. aim the present study was to develop validate an applicable sensitive HPLC-FLD method quantitative determination pyridoxine (PYR) melatonin (MEL) in a chocolate formulation that suitable treatment insomnia. proposed chromatographic process performed on Aqua column (250 mm × 4.6 mm, 5 mm) at 45 °C, with mobile phase consisting two solvents (A, water 0.2% formic acid; B, acetonitrile acid)...

In recent years, the detection of nitrosamine precursors has become an important issue for regulatory authorities such as European Medicines Agency (EMA) and Food Drug Administration (FDA). The present study provides a pre-column derivatization method analysis dimethylamine (DMA) diethylamine (DEA) in pharmaceutical products using HPLC fluorescence detector. Appropriate chromatographic parameters, including mobile phase composition (organic solvent, buffer, pH), elution type, flow rate,...

There is a growing producer and consumer interest in medical devices the commensurate need for regulatory frameworks to ensure quality of marketed locally globally. This work focuses on formalizing clauses enacted by Regulation (EU) 2017/745 risk-based classification class-based conformity assessment regarding marketability devices. The resulting knowledge base (KB) represents Positional-Slotted Object-Applicative (PSOA) RuleML integrating F-logic-like frames with Prolog-like relationships...

As automation in robotics and artificial intelligence is increasing, we will need to automate a growing amount of ethical decision making. However, decision-making raises novel challenges for designers, engineers, ethicists, policymakers, who have explore new ways realize this task. For example, engineers building wearable robots should take into consideration privacy aspects their different context-based scenarios when programming the procedures. This turn requires input order respect norms...

Abstract As automation in artificial intelligence is increasing, we will need to automate a growing amount of ethical decision making. However, decision- making raises novel challenges for engineers, ethicists and policymakers, who have explore new ways realize this task. The presented work focuses on the development formalization models that aim at ensuring correct behaviour intelligent agents, provable way, extending implementing logic-based proving calculus based argumentation reasoning...

In order to meet the analytical requirements of European Medicines Agency (EMA), a new HPLC-FLD method was successfully developed using dansyl chloride for derivatization and determination genotoxic impurities N-Nitrosodimethylamine (NDMA) N-Nitrosodiethylamine (NDEA) in Lisinopril API its final product. Samples’ pretreatment includes liquid–liquid microextraction, denitrosation, steps. To optimize process, parameters contributing high sensitivity yielding reliable results were thoroughly...

This work implements argumentation as the basis for modeling relevant EU legislation concerning medical devices classification. Stakeholders can consult a web application determining risk-based class of device based on legislation. The described approach is generally applicable to any other analogous cases decision-making legislative regulations. One main advantages using explainability and high modularity software permitting extension and/or modification code when new regulations become available.

Abstract Wearable robots are devices intended to improve the quality of users’ life by augmenting, assisting, or substituting human functions. Exoskeletons one most widespread types wearable robots, currently used extensively in medical applications (and also for industrial, assistive, military purposes), thus governed regulations and their conformity assessment. On top that, manufacturers must specify if exoskeletons can be categorized as machines and, therefore, additionally apply a number...

Due to the rapid increase in use of anti-aging cosmetic products, there is a need develop valid analytical methods control their quality. The present work deals with development and validation new chromatographic method for quantitative determination five lipophilic components (resveratrol, ferulic acid, quercetin, retinol, α-tocopherol), properties, cold cream (w/o). For HPLC-UV separation active ingredients, an HS, Discovery® Supelco (Supelco Inc., Bellefonte, PA, USA), C18 column (25 cm ×...

Abstract In this paper, we introduce the subject of special issue Trends in Argumentation Logic . Here mainly describe two approaches to argumentation logic with explicating monotonic and non-monotonic, or defeasible, reasoning explain role artificial intelligence applying logic. Then give a short overview papers contributed issue.

This work implements argumentation as the basis for modeling relevant EU legislation concerning medical devices classification. Stakeholders can consult a web application determining risk-based class of device based on legislation. The described approach is generally applicable to any other analogous cases decision-making legislative regulations. One main advantages using explainability and high modularity software permitting extension and/ or modification code when new regulations become available.

Abstract This paper explores the relationship between informal reasoning, creativity in mathematics, and problem solving. It underscores importance of environments that promote interaction, hypothesis generation, examination, refutation, derivation new solutions, drawing conclusions, reasoning with others, as key factors enhancing mathematical creativity. Drawing on argumentation logic, proposes a novel approach to uncover specific characteristics development formalized proving using...

Abstract Proof requires a dialogue between agents to clarify obscure inference steps, fill gaps, or reveal implicit assumptions in purported proof. Hence, argumentation is an integral component of the discovery process for mathematical proofs. This work presents how theories can be applied describe specific informal features development proof-events. The concept proof-event was coined by Goguen who described proof as public social event that takes place space and time. new...