A5103089899- Pancreatic function and diabetes
- Regulation of Appetite and Obesity
- Metabolism, Diabetes, and Cancer
- Diabetes Treatment and Management
- Diet and metabolism studies
- Diabetes and associated disorders
- Diabetes Management and Research
- Sleep and Wakefulness Research
- Nutrition and Health in Aging
- Adipose Tissue and Metabolism
- Biochemical Analysis and Sensing Techniques
- Diet, Metabolism, and Disease
- Neuropeptides and Animal Physiology
- Gout, Hyperuricemia, Uric Acid
- Liver Disease Diagnosis and Treatment
- HIV-related health complications and treatments
- Bariatric Surgery and Outcomes
- Neonatal and fetal brain pathology
- Stress Responses and Cortisol
- Analytical Chemistry and Chromatography
- Chronic Disease Management Strategies
- Analytical Methods in Pharmaceuticals
- Diabetes Management and Education
- Retinal Diseases and Treatments
- Trauma, Hemostasis, Coagulopathy, Resuscitation
Pudong Medical Center
2014-2025
Fudan University
2014-2025
Hebei Medical University
2023-2024
Pudong New Area People's Hospital
2023
University of California, San Francisco
2023
Shanghai University
2022
Third Affiliated Hospital of Sun Yat-sen University
2017
Sun Yat-sen University
2017
Shanghai University of Traditional Chinese Medicine
2013-2014
Shuguang Hospital
2013-2014
The dynamic interplay between serotonin [5-hydroxytryptamine (5-HT)] neurotransmission and the hypothalamic–pituitary–adrenal (HPA) axis has been extensively studied over past 30 years, but underlying mechanism of this interaction not defined. A possibility receiving little attention is that 5-HT regulates upstream corticotropin-releasing hormone (CRH) signaling systems via activation 2C receptors (5-HT<sub>2C</sub>Rs) in paraventricular nucleus hypothalamus (PVH). Through complementary...
The burden of type 2 diabetes and its associated premature morbidity mortality is rapidly growing, the need for novel efficacious treatments pressing. We report here that serotonin 2C receptor (5-HT(2C)R) agonists, typically investigated their anorectic properties, significantly improve glucose tolerance reduce plasma insulin in murine models obesity diabetes. Importantly, 5-HT(2C)R agonist-induced improvements homeostasis occurred at concentrations agonist had no effect on ingestive...
This study investigates the possible effect and central mechanism of novel antidiabetic medication sodium glucose transporter-2 (SGLT-2i) on cardiovascular activity.Thirty-four normal male C57BL/6 mice were randomly assigned to 2 groups receive single Dapagliflozin (1.52mg/kg) dose via intragastric gavage or a comparable saline. Glycemic level (BG), blood pressure (BP) heart rate (HR) measured hours after administration respective treatments. Immunohistochemical tests performed determine...
OBJECTIVE To determine whether the medial amygdalar nucleus (MAN) represents a novel brain glucose-sensing region involved in detection of hypoglycemia and generation counterregulatory hormone response. RESEARCH DESIGN AND METHODS Fura-2 calcium imaging was used to assess glucose responsivity neurons isolated from MAN single-cell real-time reverse transcription PCR examine gene expression within glucose-responsive neurons. In vivo studies with local perfusion glucoprivic agent,...
Abstract CRH is widely expressed in the brain and of broad functional relevance to a number physiological processes, including stress response, parturition, immune ingestive behavior. To delineate further organization central network, we generated mice expressing green fluorescent protein (GFP) under control promoter, using bacterial artificial chromosome technology. Here validate CRH-GFP transgene expression within specific regions confirm distribution GFP-producing cells faithfully...
Local delivery of glucose into a critical glucose-sensing region within the brain, ventromedial hypothalamus (VMH), can suppress counterregulatory responses to systemic hypoglycemia. Here, we investigated whether this suppression was accomplished through changes in GABA output VMH. Sprague-Dawley rats had catheters and guide cannulas implanted. Eight ten days later, microdialysis-microinjection probes were inserted VMH, they dialyzed with varying concentrations from 0 100 mM. Two groups...
Direct Observation of Procedural Skills (DOPS) is a clinical assessment tool that enables trainers to observe medical students' procedural abilities in real-time settings. It assesses knowledge application, decision-making, and skill proficiency during tasks. This study modifies the DOPS evaluate operation insulin pumps (PUMP) continuous glucose monitoring systems (CGMS) diabetes management. Key elements modified include 1) Knowledge Assessment: Evaluating understanding PUMP CGMS, including...
Blood glucose concentration is tightly regulated by the rate of insulin secretion and clearance, a process partially controlled sensory neurons serving as metabolic sensors in relevant tissues. The activity these products metabolism which regulate transmitter release, recent evidence suggests that neuronally expressed ion channels transient receptor potential (TRP) family function this critical process. Here, we report novel finding cold menthol-gated channel TRPM8 necessary for proper...
The present study investigated the effects of Astragalus polysaccharides (APS) on insulin resistance by modulation hepatic sirtuin 1 (SIRT1)‑peroxisome proliferator‑activated receptor (PPAR)‑γ coactivator (PGC)‑1α/PPARα‑fibroblast growth factor (FGF)21, and glucose lipid metabolism. Thirty male Sprague Dawley rats were divided into three groups: A normal control group, a catch‑up group an APS‑treated (APS-G) group. latter two groups underwent food restriction for 4 weeks, prior to being...
Pharmacological compounds enhancing serotonergic tone significantly decrease food intake and are among the most clinically efficacious treatments for obesity. However, central mechanisms through which modulate feeding behavior have not been fully defined. The primary relay center receiving visceral gastrointestinal information in nervous system is nucleus of solitary tract (NTS) caudal brainstem. Here we investigated whether classic anorectic serotonin receptor agonist...
Abstract Background Sarcopenia, an age-related disorder characterized by loss of skeletal muscle mass and function, is recently recognized as a complication in elderly patients with type 2 diabetes mellitus (T2DM). Skeletal muscles play crucial role glycemic metabolism, utilizing around 80% blood glucose. Accordingly, we aimed to explore the relationship between glucose metabolism T2DM. Methods We employed AWGS 2019 criteria for diagnosing low 1999 World Health Organization (WHO) diagnostic...
Maintaining glucose levels within the appropriate physiological range is necessary for survival. The identification of specific neuronal populations, discreet brain regions, sensitive to changes in concentration has led hypothesis a central glucose-sensing system capable directly modulating feeding behaviour. Glucokinase (GK) been identified as glucose-sensor responsible detecting such both and periphery. We previously reported that antagonism centrally expressed GK by administration...