A5103105364- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Angiogenesis and VEGF in Cancer
- RNA modifications and cancer
- Cell Adhesion Molecules Research
- Cancer, Hypoxia, and Metabolism
- Neuroinflammation and Neurodegeneration Mechanisms
- RNA Research and Splicing
- Chemokine receptors and signaling
- Pancreatitis Pathology and Treatment
- Proteoglycans and glycosaminoglycans research
- RNA and protein synthesis mechanisms
- Viral Infections and Immunology Research
Sichuan University
2012-2023
West China Hospital of Sichuan University
2012-2023
Wuhan University
2015-2019
RNA helicases and chaperones are the two major classes of remodeling proteins, which function to remodel structures and/or RNA-protein interactions, required for all aspects metabolism. Although some virus-encoded helicases/chaperones have been predicted or identified, their activities in vitro functions viral life cycle remain largely elusive. Enteroviruses a large group positive-stranded viruses Picornaviridae family, includes numerous important human pathogens. Herein, we report that...
To investigate the effects of vascular endothelial growth factor A (VEGFA) and underlying molecular mechanisms on migration human dental pulp stem cells (hDPSCs).The expression VEGFA in inflammatory tissue lipopolysaccharide (LPS)-stimulated was examined by immunofluorescence staining qRT-PCR. The hDPSCs detected using transwell wound healing assays. activation FAK, PI3K, Akt p38 signalling evaluated Western blot analysis. Silence RNA (siRNA) technology utilized to knockdown VEGFR1 (Flt-1)...
Background: MicroRNAs (miRs) are non-coding RNAs that could regulate gene expression. Until now, very little is known about miRs' role during ischemia/reperfusion (I/R). It was reported microRNA-21 (miR-21) a strong anti-apoptotic factor in cancer cells. But its I/R normal cell have not been fully clarified. So we investigated whether can protect human umbilical vein endothelial cells (HUVECs) against apoptosis induced by hypoxia injury. Methods: We employed real-time RT-PCR to investigate...
Background: Hypoxia inducible factor-1 alpha (HIF-1 alpha) plays an important role in ischemia/reperfusion (I/R). It has been shown that miR- 494 could lead to cardioprotective effects against I/R-induced injury, but its functional relationship with HIF-1 not fully clarified. This study was undertaken determine if miR-494 is a regulator of hypoxia. Methods: We employed real-time PCR investigate the expression pattern after 4, 8 and 16h hypoxia human liver cell line L02, western blot detect...
Background: Human MHC class I chain-related (MIC) gene family have been reported to be associated with poor transplant outcomes. The causes of MIC expression and the relative regulation mechanisms are still unclear. If recipients taking CsA local inflammation or rejection on graft, tissue hypoxia would occur. We previously that ischemia/reperfusion (I/R) immunosuppressant alone up regulate MICA. So we explored possible mechanism upregulation MICA induced by I/R CsA. Methods: HK-2 cells were...