A5064811651- Marine Sponges and Natural Products
- Microbial Natural Products and Biosynthesis
- Protein Hydrolysis and Bioactive Peptides
- Marine Toxins and Detection Methods
- Chromium effects and bioremediation
- Seaweed-derived Bioactive Compounds
- Synthetic Organic Chemistry Methods
- Heavy metals in environment
- Echinoderm biology and ecology
- Metal Extraction and Bioleaching
- Nicotinic Acetylcholine Receptors Study
- Methane Hydrates and Related Phenomena
- Invertebrate Immune Response Mechanisms
- Neuroscience and Neuropharmacology Research
- Antimicrobial Peptides and Activities
- Trace Elements in Health
- Microbial Community Ecology and Physiology
- Molecular Sensors and Ion Detection
- Biochemical effects in animals
- Iron Metabolism and Disorders
- Chemical synthesis and alkaloids
- Cassava research and cyanide
- Biochemical and Structural Characterization
- Mine drainage and remediation techniques
- Metal-Organic Frameworks: Synthesis and Applications
Universidade de São Paulo
2007-2025
Universidade Federal do Amazonas
2015
Universidade do Estado do Amazonas
2011-2015
Escola Superior de Ciências da Saúde
2011
Despite the large number of reports describing sponge-microbe associations, limited knowledge is available about associated fungi and their relationships with hosts. In this work, specific fungal strains were obtained directly from in vitro sponge cell cultures (primmorphs) single cells (cytospins) compared those whole tissue preparations. A total 27 isolated marine sponges Hymeniacidon heliophila Haliclona melana. Fifteen strains, nine H. six melana, considered as possible mesohyl or...
Ucides cordatus (Linnaeus, 1763) is a hypo-hyper-regulating mangrove crab possessing gills for respiratory and osmoregulatory processes, separated in anterior posterior sections. They also have hepatopancreas, which responsible digestion absorption of nutrients detoxification toxic metals. Each these organs has specific cells that are important vitro studies cell biology, ion metals transport. In order to study characterize from both were using Sucrose Gradient (SG) 10 40% each gradient...
Abstract Proteomic analysis of the fungus Aspergillus niger showed that its capacity to absorb metals was boosted by physiological modification under metal stress conditions. To investigate proteome elicited copper stress, mine-isolated strain A. IOC 4687 cultured in absence (control) or presence ions (50 mg L−1) for 72 h. Protein extract from each treatment analyzed nano-liquid chromatography-mass spectrometry and proteins were identified using PEAKS Studio 8.5 software. Grouping functional...
2023 was the hottest year ever recorded, global warming accelerates its rising, we witness a series of extreme weather events, more frequent and intense, climate refugees, infrastructure harmed, forests burning, “meteorological tsunamis”. We failed to meet main goals Kyoto protocol; are very close fail in meeting Paris agreement’s slowing goal. Greenhouse gases emissions at rise and, even if completely halt, temperatures would keep enhancing average. Carbon capture storage technologies being...
Salmonella genus is a leading cause of food-borne infections with strong public health impact and economic ramifications. The development antimicrobial resistance added complexity to this scenario turned the antibiotic drug discovery into highly important challenge. screening peptides has served as successful platform design new candidates. Motivated by this, cytotoxic properties three cruzioseptins against Typhimurium RAW 264.7 murine macrophage cells, respectively, were investigated....
The red seaweed Galaxaura marginata (Ellis & Solander) Lamouroux, well known by the antibacterial activity of its polar extract and cytotoxic oxygenated desmosterol, showed anti-inflammatory action in apolar fraction. Topical was observed samples collected at São Sebastião channel, northern littoral Paulo State, Brazil. fractions obtained through Thin-Layer Chromatography (TLC) reduced topical inflammation produced croton oil mouse ear. Such data indicated that from marine alga G. displayed...
Four substances purified by HPLC from red seaweed Galaxaura marginata (Ellis & Solander) Lamouroux showed neuroprotective and mitochondria regulatory properties in neuroblastoma NEURO-2A cells line. Under oxidative basal conditions, each substance is capable of modifying the glutamate, glutamine alanine intracellular concentrations, without to alter equilibrium these cells. These substances, also, produced a biphasic activity mitochondrial metabolism, inhibiting, lower concentrations...
Abstract Metabolomic and secretomic analyses of Aspergillus niger IOC 4687 indicated the features resistance this strain to copper stress. To investigate metabolites produced under oxidative stress conditions, gas chromatography–mass spectrometry analysis was performed. The secretome principal component results showed that mannitol could be main metabolite responsible for conferring fungus, gluconic acid is possible cause desorption because its chelating ability. meta-analysis metabolome A....
Symbionts in sponges must interact with the host immune system, and this can be mediated by immunomodulators. As bases of system resemble those higher metazoans, it is possible that compounds from microbiota show similar effects other phyla. It also known several antibiotics, special macrolides, modulate many components response their associated microorganisms are a rich source these compounds. Therefore, we tested immunosuppressive capacity antibiotic substances produced bacterial fungal...
Over the last 20 years, our group has collected different species of marine organisms occurring in Brazilian coastline. The pharmacological approach is evaluation effects organic extracts, or purified and isolated compounds laboratory animals, organs, tissues, cells to define profile biological activity mechanisms action. Different bioassays are currently used including hemolytic cytotoxicity, neurotoxicity, neuromuscular junction preparations. Furthermore, biologically active substances...
Neurotoxic activity of polar substances extracted from the red seaweed Galaxaura marginata was investigated in pharmacological assays, using collected at São Sebastião channel (45º25' W; 26º49' S) northern coast State Paulo, Brazil. High concentration fraction (PF) and PF filtered through a membrane (1000 Da) intraperitoneally (IP) injected mice were lethal, inducing ataxia, disorientation, severe muscle atonia prior to death. The same symptoms preceding death described rat tested with...