A5061023767- Cancer Cells and Metastasis
- Cancer Genomics and Diagnostics
- Advanced Breast Cancer Therapies
- Lung Cancer Research Studies
- Cancer Immunotherapy and Biomarkers
- Lipoproteins and Cardiovascular Health
- Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Breast Cancer Treatment Studies
- Parasitic Diseases Research and Treatment
- Coronary Interventions and Diagnostics
- Health Systems, Economic Evaluations, Quality of Life
- Cardiovascular Function and Risk Factors
- 3D Printing in Biomedical Research
- Breast Lesions and Carcinomas
- Metastasis and carcinoma case studies
- Acute Myocardial Infarction Research
- Complement system in diseases
- Cardiac Health and Mental Health
- HER2/EGFR in Cancer Research
- Cancer Treatment and Pharmacology
- Pancreatic and Hepatic Oncology Research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Monoclonal and Polyclonal Antibodies Research
- Parasite Biology and Host Interactions
Hospital Arnau de Vilanova
2014-2025
University Medical Center Hamburg-Eppendorf
2016-2017
Oslo University Hospital
2017
Erasmus MC Cancer Institute
2017
Universität Hamburg
2016-2017
Hospital Clínico San Carlos
2016-2017
Kyoto University Hospital
2017
Gunma University Hospital
2017
Istituti Ospitalieri di Cremona
2016
European Institute of Oncology
2016
Abstract Purpose: The aim of PREDICT was to confirm clinical validity and the potential for utility serial circulating tumor cell (CTC) enumeration in metastatic breast cancer (MBC) patients focusing on its prognostic value different subtypes settings. Experimental design: In total, 4436 individual patient-level data with CTC results from both baseline one follow-up (CellSearch®; Menarini Silicon Biosystems) were analyzed evaluate association between detection overall survival (OS) full...
Circulating tumor cells (CTCs) are that have detached from solid tumors and entered the blood. CTCs can be detected, among others, by semi-automated immunomagnetic enrichment image cytometry using CellSearch® (Veridex, Raritan, NJ). We studied feasibility of external quality assurance (EQA) entire CellSearch procedure blood draw to interpretation results in multiple laboratories.Blood samples six cancer patients controls were distributed 14 independent laboratories test between-laboratory,...
Despite the strong prognostic stratification of circulating tumor cells (CTCs) enumeration in metastatic breast cancer (MBC), current clinical trials usually do not include a baseline CTCs their design. This study aimed to generate classifier for simulation existing datasets hypothesis generation patients with MBC. A K-nearest neighbor machine learning algorithm was trained on pooled dataset comprising 2436 individual MBC from European Pooled Analysis Consortium and MD Anderson Cancer Center...
Abstract Background We performed an international meta-analysis of individual patient data to assess the clinical validity circulating tumor cell (CTC) count in non-metastatic breast cancer (BC) patients (pts) treated by neoadjuvant chemotherapy (NCT). Methods A protocol pre-specified study objectives. a literature & abstracts search up Dec 2014, then contacted all centers deemed have eligible (published or not): early BC pts with NCT CTC CellSearch®. The primary endpoint was overall...
Abstract Background: Several studies suggest clinical utility of serial circulating tumor cell (CTC) enumeration as a means assessing response status in metastatic breast cancer (MBC). The aim this study is to conduct comprehensive pooled analysis comprising globally available data further define and explore the role CTC tool for early treatment monitoring patients with MBC focus on predictive power different subtypes settings. Methods: In global effort, peer-reviewed published repeated...
Previously, an in vitro effect was observed on the complement system not only of excretory-secretory products but also somatic antigens from L3 Anisakis simplex larvae. In present work anti-A. specific antibodies C3 and C4 levels human sera investigated. Up to 309 samples were tested determine antibodies, including immunoglobulins IgG, IgM, IgA IgE. Significant differences between all except for case immunoglobulins, probability that positive subject has a deficiency 3.8 times higher than...
Abstract Background: Clinical validity of CTCs (CellSearch®) in metastatic breast cancer (MBC) patients has previously been assessed studies with limited statistical power. We aimed to pool all European obtain high-level evidence on the prognostic value CTCs, investigate their effects across different clinico-pathological characteristics and therapies further validate MD Anderson/Institut Curie/Fox Chase CTC-based nomogram established first-line treated MBC (Giordano et al, Clin Cancer Res...
e20685 Background: Immunotherapy with anti-PD1/PDL1 monoclonal antibodies has become the second line standard treatment for most patients diagnosed of advanced Non-Small-Cell lung cancer (NSCLC). The aim this study is to assess utility circulating biomarkers such as sPDL1, sPDL2, sCD137, sIDO, sTIM3, sCD28, sCD27, sCTLA4, sHVEM, sLAG3, sCD80 and sGITR predicting efficacy immunotherapy therapies. Methods: Blood samples were collected before from 50 NSCLC who received anti PD1/PDL1 therapies...
Abstract Introduction: The expression of CTC and CK19 holds prognostic value for patients with breast cancer but their clinical significance remains still controversial. Methods: This observational study included 58 preteated metastatic who started a standard new treatment line. was measured CellSearch® RT-PCR respectively at inclusion time. Progression-free survival (PFS) defined as the time elapsed between initiation either date or radiological progression death last follow-up. Cox...
Abstract Background: The European Pooled Analysis of CTC (EPAC) in metastatic breast cancer, based on 1,944 individual data from patients with various tumor types and clinical settings (Bidard et al, Lancet Oncol 2014), has established count (CellSearch) at baseline during therapy as a level evidence 1 independent prognostic biomarker demonstrated its superiority over serum blood markers. As part the study pre-planned objectives, we sought to establish nomograms allowing accurate survival...