A5012320909- SARS-CoV-2 and COVID-19 Research
- COVID-19 Impact on Reproduction
- Respiratory viral infections research
- COVID-19 Clinical Research Studies
- Reproductive System and Pregnancy
- Kawasaki Disease and Coronary Complications
- Adolescent and Pediatric Healthcare
- Pregnancy and Medication Impact
- Viral gastroenteritis research and epidemiology
- Vaccine Coverage and Hesitancy
- Viral Infections and Immunology Research
- Systemic Lupus Erythematosus Research
- Heart Rate Variability and Autonomic Control
- Mosquito-borne diseases and control
- Spinal Cord Injury Research
- Animal Virus Infections Studies
- Smoking Behavior and Cessation
- Sleep and Work-Related Fatigue
- Long-Term Effects of COVID-19
- Inflammasome and immune disorders
- Neuroscience of respiration and sleep
- COVID-19 and healthcare impacts
Massachusetts General Hospital
2021-2024
Boston University
2021-2024
Boston Children's Hospital
2023-2024
Harvard University
2021-2022
Health and Human Development (2HD) Research Network
2022
Center of Molecular Immunology (Cuba)
2021
BACKGROUND. Weeks after SARS-CoV-2 infection or exposure, some children develop a severe, life-threatening illness called multisystem inflammatory syndrome in (MIS-C). Gastrointestinal (GI) symptoms are common patients with MIS-C, and severe hyperinflammatory response ensues potential for cardiac complications. The cause of MIS-C has not been identified to date.
Cases of adolescents and young adults developing myocarditis after vaccination with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-targeted mRNA vaccines have been reported globally, but the underlying immunoprofiles these individuals not described in detail.
The availability of three COVID-19 vaccines in the United States provides an unprecedented opportunity to examine how vaccine platforms and timing vaccination pregnancy impact maternal neonatal immunity. Here, we characterize antibody profile after Ad26.COV2.S, mRNA-1273 or BNT162b2 158 pregnant individuals evaluate transplacental transfer by profiling umbilical cord blood 175 maternal-neonatal dyads. These analyses reveal lower vaccine-induced functions Fc receptor-binding Ad26.COV2.S...
Abstract Background Data on pediatric coronavirus disease 2019 (COVID-19) has lagged behind adults throughout the pandemic. An understanding of severe acute respiratory syndrome 2 (SARS-CoV-2) viral dynamics in children would enable data-driven public health guidance. Methods Respiratory swabs were collected from with COVID-19. Viral load was quantified by reverse-transcription polymerase chain reaction (RT-PCR); culture assessed direct observation cytopathic effects and semiquantitative...
Although children have been largely spared from coronavirus disease 2019 (COVID-19), the emergence of severe acute respiratory syndrome 2 (SARS-CoV-2) variants concern (VOCs) with increased transmissibility, combined fluctuating mask mandates and school reopenings, has led to infections among children. Thus, there is an urgent need roll out COVID-19 vaccines all ages. However, whether respond equivalently adults mRNA dosing will elicit optimal immunity remain unclear. Here, we aimed deeply...
Completion of a COVID-19 vaccination series during pregnancy effectively reduces hospitalization among infants less than 6 months age. The dynamics transplacental transfer maternal vaccine-induced antibodies, and their persistence in at 2, 6, 9, 12 months, have implications for new vaccine development optimal timing administration pregnancy. We evaluated anti-COVID antibody IgG subclass, Fc-receptor binding profile, activity against wild-type Spike RBD plus five variants concern (VOCs) 153...
BackgroundAlthough emerging data during the SARS-CoV-2 pandemic have demonstrated robust messenger RNA vaccine–induced immunogenicity across populations, including pregnant and lactating individuals, rapid waning of vaccine-induced immunity emergence variants concern motivated use vaccine booster doses. Whether all will mount a comparable response to dose is not known.ObjectiveThis study aimed profile humoral immune COVID-19 in cohort pregnant, lactating, nonpregnant age-matched women.Study...
Emergent SARS-CoV-2 variants and waning humoral immunity in vaccinated individuals have resulted increased infections hospitalizations. Children are not spared from infection nor complications of COVID-19, the recent recommendation for boosters ages 12 years or older calls broader understanding adolescent immune profile after mRNA vaccination. We tested durability cross-reactivity anti-SARS-CoV-2 serologic responses over a six-month time course adolescents against D614G (“wild type”) Omicron...
The goal of this study was to investigate the relationship between anti-SARS-CoV-2-Spike IgG titers passively transferred fetus from maternal vaccination during pregnancy and timing infant SARS-CoV-2 infection. Pregnant, vaccinated individuals (n = 105) their infants 107) were enrolled in a prospective cohort July 2021 June 2022, linking anti-Spike titer at birth risk infection first fifteen months life. Cord blood sera collected delivery two six age. Anti-SARS-CoV-2-Spike levels quantified...
Data on pediatric COVID-19 has lagged behind adults throughout the pandemic. An understanding of SARS-CoV-2 viral dynamics in children would enable data-driven public health guidance. Respiratory swabs were collected from with COVID-19. Viral load was quantified by RT-PCR; culture assessed direct observation cytopathic effects and semiquantitative titers. Correlations age, symptom duration, disease severity analyzed. whole genome sequences compared contemporaneous sequences. 110 (median age...
While children have been largely spared from COVID-19 disease, the emergence of viral variants concern (VOC) with increased transmissibility, combined fluctuating mask mandates and school re-openings led to infections disease among children. Thus, there is an urgent need roll out vaccines all ages. However, whether respond equivalently adults mRNA dosing will elicit optimal immunity remains unclear. Given recent announcement incomplete induced by pediatric dose BNT162b2 vaccine in young...
Currently available mRNA vaccines are extremely safe and effective to prevent severe SARS-CoV-2 infections. However, the emergence of variants concerns (VOCs) has highlighted importance high population-based vaccine rates effectively suppress viral transmission breakthrough While initially left out from efforts, children have become one most affected age groups key targets stop community household spread. Antibodies central for vaccine-induced protection emerging data points additional Fc...
Emergent SARS-CoV-2 variants and waning humoral immunity in vaccinated individuals have resulted increased infections hospitalizations. Children are not spared from infection nor complications of COVID-19, the recent recommendation for boosters ages 12 years or older calls broader understanding adolescent immune profile after mRNA vaccination. We tested durability cross-reactivity anti-SARS-CoV-2 serologic responses over a six-month time course adolescents against wild type Omicron antigens....
Background/Aims: The increasing use of electronic cigarettes (e-cigs) has resulted in complex tobacco patterns that may change with time within individuals. We developed a mobile platform to capture and transitions over young adults. Methods: Individuals 18-45 years old the Cardiovascular Injury Due Tobacco Use (CITU 2.0) study completed detailed baseline questionnaire followed by enrollment text message-based (Agile Health, Inc) collected self-reported 24 months. Baseline (sole e-cig use,...
Patient-level predictors of enrollment in pediatric biorepositories are poorly described. Especially pandemic settings, understanding who is likely to enroll a biorepository critical interpreting analyses conducted on biospecimens. We describe COVID-19 and biospecimen donation identify gaps research biospecimens.We compared data from enrollees non-enrollees aged 0-25 years with suspected or confirmed infection were approached for the Massachusetts General Hospital between April 12, 2020, May...
Abstract BACKGROUND While emerging data during the SARS-CoV-2 pandemic have demonstrated robust mRNA vaccine-induced immunogenicity across populations, including pregnant and lactating individuals, rapid waning of immunity emergence variants concern motivated use vaccine booster doses. Whether all will mount a comparable response to dose is not known. OBJECTIVE We sought profile humoral immune COVID-19 in cohort pregnant, lactating, age-matched nonpregnant women. STUDY DESIGN characterized...
Abstract The availability of three COVID-19 vaccines in the United States provides an unprecedented opportunity to examine how vaccine platforms and timing vaccination pregnancy impact maternal neonatal immunity. Here, we characterized antibody profile after Ad26.COV2.S, mRNA-1273 or BNT162b2 158 pregnant individuals, evaluated transplacental transfer by profiling umbilical cord blood 175 maternal-neonatal dyads. These analyses revealed lower vaccine-induced functions Fc-receptor binding...
SUMMARY Completion of a COVID-19 vaccination series during pregnancy effectively reduces hospitalization among infants less than 6 months age. Elucidating the dynamics transplacental transfer maternal vaccine-induced antibodies, and their persistence in at 2, 6, 9 12 months, has implications for new vaccine development timing administration to optimize protection mother-infant dyad. We evaluated anti-COVID antibody IgG subclass, Fc-receptor binding profile, activity against wild-type Spike...