Make your OLED fluorescent: An aromatic molecule based on a spiro-acridine derivative was designed (see picture), and its photoluminescence electroluminescence were characterized. By combining the donor acceptor moieties small energy gap between lowest singlet triplet states achieved. This design leads to an organic light-emitting diode (OLED) that rivals phosphorescent devices regarding exciton generation efficiency. Detailed facts of importance specialist readers are published as...

Abstract Biosensors based on organic electrochemical transistors (OECT) are attractive devices for real‐time monitoring of biological processes. The direct coupling between the channel OECT and electrolyte enables intimate interfacing with environments at same time bringing signal amplification fast sensor response times. So far, these mainly applied to mammalian systems; cells or body fluids development diagnostics various health status technology. Yet, no detection biomolecules from...

Microbial electrochemical systems provide an environmentally-friendly means of energy conversion between chemical and electrical forms, with applications in wastewater treatment, bioelectronics, biosensing. However, a major challenge to further development, miniaturization, deployment bioelectronics biosensors is the limited thickness biofilms, necessitating large anodes achieve sufficient signal-to-noise ratios. Here we demonstrate method for embedding electroactive bacterium, Shewanella...

Extracellular electron transfer (EET) denotes the process of microbial respiration with to extracellular acceptors and has been exploited in a range electrochemical systems (MESs). To further understand EET optimize performance MESs, better understanding dynamics at microscale is needed. However, real-time monitoring high spatiotemporal resolution would require sophisticated signal amplification. amplify local signals, miniaturized bioelectronic device, so-called organic transistor (OMECT),...

Fluoreszierend: Ein auf einem Spiroacridin-Derivat basierendes Molekül (siehe Bild) wurde synthetisiert, und seine Photo-und Elektrolumineszenz wurden untersucht. Durch Kombination der Donor- Akzeptoreinheiten eine kleine Energielücke zwischen den niedrigsten Singulett- Triplettzuständen erhalten. Das Design führte zu einer organischen Leuchtdiode, die bezüglich Effizienz Exciton-Erzeugung mit phosphoreszierenden Bauteilen konkurriert.

Intracellular delivery is crucial for drug delivery, genetic manipulation, and regenerative medicine. Traditional methods such as electroporation face are limited by low efficiency high cell toxicity caused lipid...

Intratumoral hypoxia is common in any form of malignancy initializing focal necrosis or tumor cell adaptation. Hypoxia inducible factor-1-driven reprogramming favors the loss proliferation (quiescence) and partial cellular reversion, induces stemness and/or mesenchymal-like features exposed areas. The characteristic hypoxia-driven phenotype principally directed to reduce energy consumption enhance survival, but gained also contribute growth advantage induce reorganization microenvironment...

We report on the realization of polymer light-emitting diodes (PLEDs) based fluorescent polythiophene (PT)-based insulated molecular wires (IMWs). PLEDs using PT emitting layers traditionally have low external quantum efficiencies (ηeqe) below 0.1%. Moreover, IMWs lack a thorough exploitation for electroluminescent applications due to concerns about reduced charge transport between their chains. constructed multilayer containing IMW that show maximum ηeqe close 1.4%, luminance at 3700 cd/m2,...

Abstract Background With the introduction of tissue microarrays (TMAs) researchers can investigate gene and protein expression in tissues on a high-throughput scale. TMAs generate wealth data calling for extended, high level management. Enhanced analysis systematic management are required traceability reproducibility experiments provision results timely reliable fashion. Robust scalable applications have to be utilized, which allow secure access, manipulation evaluation from different...

Integrating sensory devices with wireless power transfer technology for remote sensing (RS) requires the implementation of complex electronic circuitry and communication protocols. To overcome this challenge remotely monitor mechanical force, we directly integrated piezo-responsive porous multiwalled carbon nanotubes (MWCNTs)/polydimethylsiloxane (PDMS) nanocomposites a near-field system. The system transfers bidirectionally between transmitter receiver at resonant frequency 13.56 MHz....

Abstract Energy harvesting from photosynthetic membranes, proteins, or bacteria through bio‐photovoltaic bio‐electrochemical approaches has been proposed as a new route to clean energy. A major shortcoming of these and solar cell technologies is the underutilization irradiation wavelengths in IR region, especially those far region. Here, biohybrid energy‐harvesting device demonstrated that exploits radiation, via convection thermoelectric effects, improve resulting energy conversion...

Ion channels are membrane proteins that allow ionic signals to pass through channel pores for biofunctional modulations. However, biodevices integrate bidirectional biological signal transmission between a device and converter supported lipid bilayers (SLBs) while simultaneously controlling the process lacking. Therefore, in this study, we aimed develop hybrid biotransducer composed of ATP synthase proton gramicidin A (gA), controlled by sulfonated polyaniline (SPA) conducting polymer layer...

Highly fluorescent, multifunctional and thermoreversible conformational switching (1) has been designed developed by embedding two imidazo[1,2-c]quinazoline (IQ) units in the pyridyl scaffold. The origin of optical 1 to 1′ established various studies developing a model compound.

Abstract Nucleolin and fibrillarin are two histone‐like major proteins in the nucleolus that were found to be overexpressed proliferating cells. Using specific antibodies either nucleolin or flow cytometric, measurements carried out demonstrate quantitative changes of these during lymphocyte mitogenic activation differentiation HL‐60 promyelocytic leukaemia The expression increased stimulation decreased slowly but constantly course Expression reached a maximum first cell cycle then dropped...

Background: Hypoxia and necrosis are common features of invasive cancer. The dynamic upregulation carbonic anhydrase IX (CAIX), triggered by hypoxia-inducible factor 1 (HIF-1) is the mechanisms supporting cellular adaptation to hypoxia in solid tumors, including breast carcinoma. CAIX activity results extracellular acidosis a profound reorganization tumor micro-environment, influencing biological behavior prognosis. main focus our study was evaluate mass distribution immune infiltrate, more...

Measurements on DNA content and steroid receptor status in breast cancer are of great clinical interest. Objective determination estrogen progesterone expression should help to define the lowest levels positivity still responding adjuvant antihormonal therapy. For this purpose, a simple protocol for laser scanning cytometry is presented.Analysis 54 routine samples was performed by (LSC). To obtain single cell preparations from fresh tumor tissue, slides were prepared using Cervisoft...

The Wilms tumor 1 (WT1) gene is currently in focus by pediatric nephrologists as its mutations are associated with nephrotic syndrome, especially part of complex clinical entities like Denys-Drash or Frasier syndrome. Renal failure may also develop young WAGR patients, whose condition attributed to a deletion at chromosomal region 11p13. However, only limited data exist on WT1 microdeletions. A 30-year-old male patient, history genital malformations, manifested during the treatment acute...

Abstract Pulse oximetry is widely used in medical settings and everyday life for the estimation of peripheral blood oxygen saturation (SpO 2 ). However, SpO response measured on parts body (such as fingers wrists) has a time lag compared to measuring forehead. In addition, current devices are centimeter‐thick, making seamless integration with difficult, hindering continuous monitoring. Here design, fabrication, evaluation heart rate sensor based flexible hybrid electronics (FHE) presented....

Sodium ions and protons regulate various fundamental processes at the cell tissue levels across all biological kingdoms. It is therefore pivotal for bioelectronic devices, such as biosensors biotransducers, to control transport of these through membranes. Our study explores regulation proton sodium concentrations by integrating an Na+-type ATP synthase, a glucose dehydrogenase (GDH), urease into multienzyme logic system. This system designed operate using chemical input signals, while output...

Microbial electrochemical systems (MESs) rely on the microbes' ability to transfer charges from their anaerobic respiratory processes electrodes through extracellular electron (EET). To increase generally low output signal in devices, advanced bioelectrical interfaces tend augment this problem by attaching conducting nanoparticles, such as positively charged multiwalled carbon nanotubes (CNTs), base electrode electrostatically attract negatively bacterial cell membrane. On other hand, some...