Wireless implantable neural interfaces can record high-resolution neuropotentials without constraining patient movement. Existing wireless systems often require intracranial wires to connect implanted electrodes an external head stage or/and deploy application-specific integrated circuit (ASIC), which is battery-powered or externally power-transferred, raising safety concerns such as infection, electronics failure, heat-induced tissue damage. This work presents a biocompatible, flexible,...

Implantable systems are often employed to perform continuous high-resolution recordings of neural activity. These frequently require invasive procedures when implanting and maintaining effective operation. This causes major interruptions daily life. Previous work demonstrated an in vitro minimum detectable signal 15 μV amplitude RF sensitivity down -135 dBm. suggests the possibility detecting diminutive biopotentials a wireless fully passive manner. Here, for first time, we validate...

Optogenetic targeting of astrocytes provides a robust experimental model to differentially induce Ca 2+ signals in vivo . However, systematic study quantifying the response optogenetically modified light is yet be performed. Here, we propose novel stochastic dynamics that incorporates sensitive component—channelrhodopsin 2 (ChR2). Utilizing this model, investigated effect different stimulation paradigms on cells expressing select variants ChR2 (wild type, ChETA, and ChRET/TC). Results...

Astrocytes are actively involved in a neuroprotective role the brain, which includes scavenging reactive oxygen species to minimize tissue damage. They also modulate neuroinflammation and gliosis prevalent several brain disorders like epilepsy, Alzheimer's, Parkinson's disease. In animal models, targeted manipulation of astrocytic function via modulation their calcium (Ca2+ ) oscillations by incorporating light-sensitive cation channels Channelrhodopsin-2 (ChR2) offers promising avenue...

To address the need for high-quality brain monitoring, implantable systems are often used. However, these require significantly invasive procedures. This paper presents development of probes specific to a device that can be used record neural data during normal day-to-day activity. Here, design low-impedance fully-passive wireless implant is introduced and employed in series vitro experiments. The integration neurosensing system results enhanced impedance matching. As result, signals as low...

To address the need for continuous and localized brain electrical activity recordings, implantable neurosensing systems are often used. However, current involve highly-invasive procedures that can interrupt day-to-day activities. This paper presents an approach developing a device be used to obtain neural data during normal without hindering quality of life. In this paper, first time, we present design application improved probes fully-passive wireless implant. The integration these system...

Neural implants are used to continuously record essential signals in studies of neurological disorders. Existing systems involve the use invasive procedures and revision surgeries maintain adequate system performance. Our previous work demonstrated a fully-passive wireless system, tested vitro, was capable sensing even minute neural signals. This recorder has minimum detectable signal (MDS) below 15 μV amplitude RF sensitivity down about - 135 dBm. While results have been promising, this is...

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Implantable sensors for recording neural activity are often used a variety of applications, including epilepsy studies. Current versions these recorders highly-invasive impractical implants and undesirable in daily life. To address this, the first time we present novel fully- implantable passive system characteristic epileptic activity. In this paper, focus on interictal epileptiform discharges (IEDs), known indicators clinical significance. IEDs can serve to identify location seizure onset...

A wireless neurosensing system (WiNS) adapted with a novel impedance matching network is presented and validated. This used in vivo to record for the first time spontaneous neural unit activity from hippocampus of Wistar rat. These extracellular spikes offer valuable information. However, they are challenging observe, even more so previously reported systems due mismatches required probes. The notable result demonstrated here employed (a) recently proposed technique passive matching, (b)...

Abstract Understanding the roles of astrocytic calcium signaling in multiple brain regulatory mechanisms including metabolism, blood flow, neuromodulation and neuroinflammation has remained one enduring challenges glial biology. To delineate contribution from concurrent neuronal activity, it is vital to establish robust control manipulate astrocytes using a technique like optogenetics due its high cellular specificity temporal resolution. Lack an experimental paradigm induce controlled...

Neuronal activity recordings are essential for evaluating and understanding the brain's function possible neurological disorders. In this paper, we present a first of kind 3D additive manufactured sensor recording biopotentials in battery-less wireless manner. This was done by establishing an RF link between implanted device exterior interrogator. The associated antennas designed optimized to achieve best performance communicating through skin. addition, matching circuit integrated...

Abstract Control of astrocytes via modulation Ca 2+ oscillations using techniques like optogenetics can prove to be crucial in therapeutic intervention a variety neurological disorders. However, systematic study quantifying the effect optogenetic stimulation is yet performed. Here, we propose novel stochastic dynamics model that incorporates light sensitive component – channelrhodopsin 2 (ChR2). Utilizing this model, studied various pulsed paradigms on for select variants ChR2 (wild type,...

A unique system, namely the wireless neurosensing system (WiNS) is tested, for first time, in a freely moving animal. WiNS was designed to sense neural signals battery-free manner, without using complex electronics, and by integrating key components: (a) implant external interrogator, (b) probes, (c) demodulation circuit. In this paper, set of vivo experiments are carried out demonstrate recovery associated with transitions among states awareness, while alternating between resting walking,...

Electrical activity recordings are critical for evaluating and understanding brain function. We present a novel wireless, implantable, battery-free device, namely the Wireless Neurosensing System (WiNS), first time, we evaluate multichannel recording capabilities in vivo . For preliminary evaluation, performed benchtop experiment with emulated sinusoidal signals of varying amplitude frequency, representative neuronal activity. later analyzed electrocortical rats evoked somatosensory response...

Neuropotentials monitoring can help individuals to significantly enhance their physical and mental well-being. We present an evaluation of a multichannel, passive fully implantable wireless neurosensing system (WiNS). WiNS employs radiofrequency optical communications address the need for non-battery-operated systems. In this study, we will new automated technique identify signal segments eliminating difficulty manual classification evoked biopotentials. addition, machine learning algorithms...

Flexible electrode arrays with low impedance are becoming critical to enhance single-neuron sensing high sensitivity. Such electrodes should be scalable micron dimensions and yet retain impedance. The key accomplish this is achieve: a) higher effective surface area obtain capacitance, b) chemically stable biocompatible materials no adverse reactions toxicity, c) mechanically compliant structures for minimal scar tissue formation. Nanostructured emerging such as graphene PEDOT -PSS projected...